DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8A1 and ATP8B

DIOPT Version :9

Sequence 1:	XP_011511917.1	Gene:	ATP8A1 / 10396	HGNCID:	13531	Length:	1171	Species:	Homo sapiens
Sequence 2:	NP_731669.2	Gene:	ATP8B / 41469	FlyBaseID:	FBgn0037989	Length:	1726	Species:	Drosophila melanogaster

Alignment Length:	1489	Identity:	489/1489 - (32%)
Similarity:	710/1489 - (47%)	Gaps:	385/1489 - (25%)

- Green bases have known domain annotations that are detailed below.

Human     1 MPTMRRTVSEIRSRAEGYEKTDDVSEKTSLADQEEVRTIFINQPQLTKFCNNHVSTAKYNIITFL 65
            :|::|| :|:||.|...|..::  :|:...|:.:|....|       |:.||::.|:||::.|||
  Fly   171 VPSLRR-LSQIRRRRSSYYFSE--NERRIRANDKEFNAQF-------KYHNNYIKTSKYSLFTFL 225

Human    66 PRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAV 130
            |..|..||:|.||.:||.:.:||.||.:|.....||.:||:.:|.:.|:|:..:||:||.:|:.|
  Fly   226 PFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQV 290

Human   131 NKKQTQVLRNGAWEIVHWEKVNVGDIVIIKGKEYIPADTVLLSSSEPQAMCYIETSNLDGETNLK 195
            |.::::.||||......|.:|.|||::.:...:::.|||:|||:|||..:|:|||:.||||||||
  Fly   291 NNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEPNGLCFIETAELDGETNLK 355

Human   196 IRQGLPATSDIKD-VDSLMRISGRIECESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRN 259
            .:|.|..|.::.| .|||...:|.|.||.||..|..|.|.:...|. ...|..::|||||..|||
  Fly   356 AKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQ-RFALDNEKILLRGCVLRN 419

Human   260 TQWVHGIVVYTGHDTKLMQNSTSPPLKLSNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHS 324
            |||.:|:||:.|.||||||||.....|.:.|:|:.|..|:.:...|:::..:.::|.|||... .
  Fly   420 TQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGIVLFLVSICALFAIGCAIWEGL-I 483

Human   325 GKDWYLNLNY----------GGASNFG-LNFLTFIILFNNLIPISLLVTLEVVKFTQAYFINWDL 378
            |:.:.|.|.:          .||:..| |.|.::.|:.|.::||||.|::||::|.|::.||||.
  Fly   484 GQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTVVPISLYVSVEVIRFVQSFLINWDE 548

Human   379 DMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGHV--------- 434
            :|:|..|:|.|.|||:.|||||||::|||||||||||.|:|.|.||:|.|.:||.|
  Fly   549 EMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCSINGRSYGDVIDLRTGELV 613

Human   435 -----------------PEP--------------------------------------------- 437
                             |.|
  Fly   614 EITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRP 678

Human   438 -------------------------------EDY-------------GCSP-------------- 444
                                           :|.             |.||
  Fly   679 RSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGSGGLSPPVGNEERRISGGFK 743

Human   445 ----------------------------------------------------------------- 444

  Fly   744 RSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQL 808

Human   445 ----DE------------------------WQNS-------QFGD-------EKTFS--DSSLLE 465
                ||                        |.:|       |..|       |..|.  |.:||:
  Fly   809 EHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSANPHHESDFRWYDRTLLD 873

Human   466 NLQNNHPTAPIICEFLTMMAVCHTAVPEREGDKIIYQAASPDEGALVRAAKQLNFVFTGRTPDSV 530
            .::::...:.:   |..::|:|||.:.|....|:.|||.||||.|||.||:...|||..|||:|:
  Fly   874 AVRSDEEHSHV---FFRLLALCHTVMAETVDGKLEYQAQSPDEAALVSAARNFGFVFRTRTPNSI 935

Human   531 IIDSLGQEERYELLNVLEFTSARKRMSVIVRTPSGKLRLYCKGADTVIYDRL-AETSKYKEITLK 594
            .|:.:||.|.|||||:|:|.:.|||||||:|. ...:.|||||||.|||||| ......|..|..
  Fly   936 TIEVMGQTEEYELLNILDFNNVRKRMSVILRR-GDSMVLYCKGADNVIYDRLHGGQEDLKARTQD 999

Human   595 HLEQFATEGLRTLCFAVAEISESDFQEWRAVYQRASTSVQNRLLKLEESYELIEKNLQLLGATAI 659
            ||.:||.||||||..|...::|..:.:||:..|.|:.|:.:|..||...||.||..:||:|.|||
  Fly  1000 HLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAI 1064

Human   660 EDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCKLLKKNMGMIVINEG-SLDVEDRAV 723
            ||||||.||::|..|..|.||||:|||||||||||||:||:||...:..:.|.:| |::..::.:
  Fly  1065 EDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQL 1129

Human   724 EGTRETL---------------------------------------------------------- 730
            ...:|::
  Fly  1130 RQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFR 1194

Human   731 -------------SRHCTTL-GDALRKEN------------DFALIIDGKTLKYALTFGVRQYFL 769
                         |..|..| ||....|:            .|||:::|.:|.:.|:..:...||
  Fly  1195 WDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASIVVDENTGFALVVNGHSLVHCLSPELENKFL 1259

Human   770 DLALSCKAVICCRVSPLQKSEVVEMVKKQVKVVTLAIGDGANDVSMIQTAHVGVGISGNEGLQAA 834
            |:|..|||||||||:||||:.|||::|:....|||||||||||||||:.||:||||||.|||||.
  Fly  1260 DIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAV 1324

Human   835 NSSDYSIAQFKYLKNLLMIHGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWC 899
            .|||||||||:||:.||::||.|:|.|:.|.:.|.||||....:...|::...|||.|.:|:...
  Fly  1325 LSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMF 1389

Human   900 IGLYNVMFTAMPPLTLGIFERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFW 964
            |.:||:.:|::|.|.||:||:....:|.|::|.||.....:..||.:.|....|:|.|.|::||.
  Fly  1390 ISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFL 1454

Human   965 FPLKALQYGTAFGNGKTSDYLLLGNFVYTFVVITVCLKAGLETSYWTWFSHIAIWGSIALWVV-- 1027
            .|....:.|.:......||::.||..|.|.:::....:..|.|||||..:|:.||||:..:.|
  Fly  1455 IPYGVYKDGVSANGFVVSDHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLD 1519

Human  1028 FFGIYSSLWPAIPMAPDMSGEAAMLFSSGVFWMGLLFIPVASLLLDVVYKVIKRTAFKTLVDEVQ 1092
            :|..|....|.:       |..........||:.:|...:|.:...:.||........:|.|::
  Fly  1520 YFYNYVIGGPYV-------GSLTQAMKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPSLSDKI- 1576

Human  1093 ELEAKSQDPGAVVLGKSLTERAQLLKNVFKKNHVNLYRSESL---QQNLLHGYAFSQDE 1148
                                |.:.||.:..:...::.|:.|.   ::::..||||:..|
  Fly  1577 --------------------RQKSLKKIHSRASSDVRRTASSRRGRRSVRSGYAFAHQE 1615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A1	XP_011511917.1	PhoLip_ATPase_N	38..100	CDD:292826	24/61 (39%)
		ATPase-Plipid	49..1093	CDD:273734	466/1381 (34%)
		E1-E2_ATPase	106..>191	CDD:278548	34/84 (40%)
		Cation_ATPase	486..581	CDD:289987	53/94 (56%)
		HAD_like	<803..853	CDD:304363	40/49 (82%)
		PhoLip_ATPase_C	834..1086	CDD:292829	84/253 (33%)
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	26/71 (37%)
		Cation_ATPase	891..985	CDD:289987	53/94 (56%)
		HAD_like	<1261..1324	CDD:304363	45/62 (73%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	84/253 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.730