DRSC/TRiP Functional Genomics Resources

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Protein Alignment ATP8A1 and CG33298

DIOPT Version :9

Sequence 1:XP_011511917.1 Gene:ATP8A1 / 10396 HGNCID:13531 Length:1171 Species:Homo sapiens
Sequence 2:NP_995666.1 Gene:CG33298 / 2768929 FlyBaseID:FBgn0032120 Length:1517 Species:Drosophila melanogaster


Alignment Length:1335 Identity:409/1335 - (30%)
Similarity:642/1335 - (48%) Gaps:271/1335 - (20%)


- Green bases have known domain annotations that are detailed below.


Human     3 TMRRTVSE---IRSRAEGYEKTDDVSEKTSLADQEEVRTIFINQ---PQLTK-------FCNNHV 54
            |:|||.:.   .|.....|...|...|::       .||:..|.   |:..|       |..|.:
  Fly   198 TLRRTEAPPWWKRLTLCNYNTGDKFEERS-------YRTVVPNHTVPPKTPKRDHPNGQFVGNKI 255

Human    55 STAKYNIITFLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIE 119
            .|.||.:::|:|:.|..||.|.||.:|:||.||..:|::|..|:...::|:||:|.|.|:|::.|
  Fly   256 RTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFE 320

Human   120 DIKRHKADNAVNKKQTQVL--RNGAWEIVHWEKVNVGDIVIIKGKEYIPADTVLLSSSEPQAMCY 182
            |.:|..:|..:|....:|.  ....::.|.|:::.|||||.:...|.:|||.:||.:|:||.:||
  Fly   321 DRRRRASDKRINNTTCRVYDGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCY 385

Human   183 IETSNLDGETNLKIRQGLPATSDIKDVDSLMRISGRIECESPNRHLYDFVGNIRLDGHGTVPLGA 247
            |:|.:||||||||.|:.:....:::.:....:...|:|.::|...||.|.|.:.......||:..
  Fly   386 IDTCDLDGETNLKRREVVRGFEEMQSIFVPSKFVSRVEADAPTTKLYRFHGALIHPTGERVPIST 450

Human   248 DQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPLKLSNVERITNVQILILFCILIAMSLVC 312
            :.:|||.::|:||.::.|||||.||:||.|.|::.|..|.|.||:..|:.::....||:.:.:|.
  Fly   451 ECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVG 515

Human   313 SVGSAIWNRRHSGKDWYLNLNYGGASNFGLN------FLTFIILFNNLIPISLLVTLEVVKFTQA 371
            ::|..:|....:    :..:.|...:....|      |.|:|::...:||:||.||:|:.|..|.
  Fly   516 AIGCRMWLSSFT----HFPVPYLPPNKLTANMESMWIFWTYIVILQVMIPLSLYVTIELCKILQV 576

Human   372 YFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGHVP- 435
            :.|:.::|:....|:.....|..|:.|||||:::||:|||||||.|.|.|::|.:.|..|.|.| 
  Fly   577 FHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPS 641

Human   436 EPEDYGCSPDEWQNSQFGDEKTFSDSSLLENLQNNHPTAPIICEFLTMMAVCHT----AVPERE- 495
            |.|.....|.........::...||.:.|.......|.|..|.|||.::|:|:|    |.|.|: 
  Fly   642 ELEKIYSKPGAPAPPLIPNDNLNSDMAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDM 706

Human   496 ----------------------------------------------------------------- 495
                                                                             
  Fly   707 MNASGIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAES 771

Human   496 ----------------------------------------------------------------- 495
                                                                             
  Fly   772 RSVTPSPPPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVI 836

Human   496 GDKI----------------------------------IYQAASPDEGALVRAAKQLNFVFTGRT 526
            ..||                                  :|:|.||||.|||.||...:.....|:
  Fly   837 NSKITSIATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRS 901

Human   527 PDSVIID--SLGQEERYELLNVLEFTSARKRMSVIVR-TPSGKLRLYCKGADTVIYDRLAETSK- 587
            |:.:::.  ..|....||:|.||.|.|:||.||::|| ..|.::.||.||||:.|...|...|. 
  Fly   902 PNQILVSMPMAGATREYEILKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHN 966

Human   588 -----YKEITLKHLEQFATEGLRTLCFAVAEISESDFQEWRAVYQRASTSVQNRLLKLEESYELI 647
                 .:|.|.:.|:::|.||||.|..|...::.:|:.:|.|.:|....|::||..:|.:|:..:
  Fly   967 SPEGILREQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKL 1031

Human   648 EKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCKLLKKNMGMIVIN 712
            |.||.|||||.|||:|||.|||||.:|:.|.|.:|:|||||.||||||.:|.||..:.|.:|.:.
  Fly  1032 ESNLTLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLT 1096

Human   713 EGSLDVEDRAVEGTRETLSRHCTT----LGDALRKENDFALIIDGKTLKYALTFGVRQY--FLDL 771
            ..|.|..:.|:......:....||    .|.:|||:.. ||::|||||.:.|....:..  ||.|
  Fly  1097 ARSRDAAETAINFYLTDMENDKTTSTLGYGQSLRKKQR-ALVVDGKTLTFILDPKSKLILPFLRL 1160

Human   772 ALSCKAVICCRVSPLQKSEVVEMVKKQVKVVTLAIGDGANDVSMIQTAHVGVGISGNEGLQAANS 836
            :..|.:|:|||.:||||:.:|::||:::.:.|||||||||||||||.|.|||||||.||:||..:
  Fly  1161 SKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMA 1225

Human   837 SDYSIAQFKYLKNLLMIHGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIG 901
            :|:::.:|:||:.||:.||.|.|:|:|:.|||.||||.....:..|:....|||||::.::..:.
  Fly  1226 ADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLM 1290

Human   902 LYNVMFTAMPPLTLGIFERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFP 966
            |||::||::|||.:|::::...::.:||.|.|||..:..:.:....||:..|:.|:.|:::|:..
  Fly  1291 LYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILLDALYQSLVIFFVA 1355

Human   967 LKALQYGTAFGNGKTSDYLLLGNFVYTFVVITVCLKAGL-----ETSYWTWFSHIAIWGSIALWV 1026
            |.|.         ..||   :|.:.:...:...||.|.|     |...||....::|..|:..:.
  Fly  1356 LCAY---------AESD---VGIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFY 1408

Human  1027 VF-----------FGIYSSLWPAIPMAPDMSGEAAMLFSSGVFWMGLLFIPVASLLLDVVYKVIK 1080
            :|           ||:.||.|...           :.|:|.|.|:        .::|..|..|:.
  Fly  1409 LFAIVYDSVCMNCFGVRSSYWVIF-----------VCFASAVHWL--------VIMLSTVVAVLP 1454

Human  1081 RTAFKTLVDEVQELEAKSQDPGAVVLGKSLTERAQ 1115
            |....|:     .:.....|...|:| :|..||::
  Fly  1455 RLLLTTV-----RISLCPDDSTKVIL-QSKRERSR 1483

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATP8A1XP_011511917.1 PhoLip_ATPase_N 38..100 CDD:292826 25/71 (35%)
ATPase-Plipid 49..1093 CDD:273734 390/1252 (31%)
E1-E2_ATPase 106..>191 CDD:278548 34/86 (40%)
Cation_ATPase 486..581 CDD:289987 42/266 (16%)
HAD_like <803..853 CDD:304363 33/49 (67%)
PhoLip_ATPase_C 834..1086 CDD:292829 74/267 (28%)
CG33298NP_995666.1 PhoLip_ATPase_N 249..299 CDD:292826 20/49 (41%)
ATPase-Plipid 250..1473 CDD:273734 391/1263 (31%)
E1-E2_ATPase 302..>394 CDD:278548 35/91 (38%)
Cation_ATPase <880..965 CDD:289987 34/84 (40%)
HAD_like <1177..1240 CDD:304363 35/62 (56%)
PhoLip_ATPase_C 1223..1468 CDD:292829 75/280 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0206
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53737
OrthoDB 1 1.010 - - D587717at2759
OrthoFinder 1 1.000 - - FOG0000076
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.830

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