DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SCML2 and lin-61

DIOPT Version :9

Sequence 1:	NP_006080.1	Gene:	SCML2 / 10389	HGNCID:	10581	Length:	700	Species:	Homo sapiens
Sequence 2:	NP_001122501.1	Gene:	lin-61 / 172467	WormBaseID:	WBGene00003041	Length:	612	Species:	Caenorhabditis elegans

Alignment Length:	250	Identity:	78/250 - (31%)
Similarity:	112/250 - (44%)	Gaps:	31/250 - (12%)

- Green bases have known domain annotations that are detailed below.

Human     5 VNEDSMDVKKENQEKT-------PQSSTSSVQRDDFHWEEYLKETGSISAPSECFRQSQIPPV-- 60
            ||...::.|||..|.|       ..........||..:::..|:              .|.|:
Worm   375 VNGYQLNAKKEYIEHTNKIAQAIKNGENPRYDSDDVTFDQLAKD--------------PIDPMIW 425

Human    61 NDFKVGMKLEARDP--RNATSVCIATVIGI--TGARLRLRLDGSDNRNDFWRL-VDSPDIQPVGT 120
            ...|||.|.|..||  :...::.:|:::..  |...|.:.:||.|...|.:.: :::..:.|||.
Worm   426 RKVKVGQKFELIDPLAQQFNNLHVASILKFCKTEGYLIVGMDGPDALEDSFPIHINNTFMFPVGY 490

Human   121 CEKEGDLLQPPLGYQMNTSSWPMFLLKTLNGSEMASATLFKKEPPKPPLNNFKVGMKLEAIDKKN 185
            .||....|.||..:: .|..|..:|.|  ..:|.....|||..|.:..|:.||||::|||.|...
Worm   491 AEKYNLELVPPDEFK-GTFRWDEYLEK--ESAETLPLDLFKPMPSQERLDKFKVGLRLEAADMCE 552

Human   186 PYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
            ...|||||:..|.|..:::.||||...||.....||.||.|.|||.....|||||
Worm   553 NQFICPATVKSVHGRLINVNFDGWDEEFDELYDVDSHDILPIGWCEAHSYVLQPP 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCML2	NP_006080.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		8/34 (24%)
		MBT 1	33..131		23/104 (22%)
		MBT	36..131	CDD:214723	23/101 (23%)
		MBT 2	139..240		41/100 (41%)
		MBT	142..240	CDD:214723	40/97 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..320
		DUF3588	356..465	CDD:288954
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	466..550
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	575..594
		SAM_Scm	625..696	CDD:188977
		SAM	628..696	CDD:197735
lin-61	NP_001122501.1	MBT	146..248	CDD:214723
		MBT	283..383	CDD:214723	2/7 (29%)
		MBT	433..505	CDD:280910	19/71 (27%)
		MBT	511..607	CDD:214723	40/97 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161457478
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840