DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SCML2 and Scml2

DIOPT Version :9

Sequence 1:	NP_006080.1	Gene:	SCML2 / 10389	HGNCID:	10581	Length:	700	Species:	Homo sapiens
Sequence 2:	XP_006528733.1	Gene:	Scml2 / 107815	MGIID:	1340042	Length:	1136	Species:	Mus musculus

Alignment Length:	1090	Identity:	407/1090 - (37%)
Similarity:	489/1090 - (44%)	Gaps:	495/1090 - (45%)

- Green bases have known domain annotations that are detailed below.

Human    15 ENQEKTPQSST--SSVQRDDFHWEEYLKETGSISAPSECFRQSQIPPVNDFKVGMKLEARDPRNA 77
            |.:|.|.:::|  .:...|.|.|::|||||||||||||.||||:.||.|:||:|||||||||||.
Mouse   130 EARENTEEANTMGQTANEDHFDWDKYLKETGSISAPSEYFRQSKTPPTNEFKIGMKLEARDPRNI 194

Human    78 TSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGYQMNTSSWP 142
            .|||:|:||||||||||||||||||:|||||||||.|||||||||:.||||||||||.:||||||
Mouse   195 DSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTCEQGGDLLQPPLGYTLNTSSWP 259

Human   143 MFLLKTLNGSEMASATLFKKEPPKPPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFD 207
            ||||:.|.|||:|.|..||:|||:|..|||.||||:||:|:|||::|||||||.|.||::|||||
Mouse   260 MFLLRVLTGSELAPAVFFKEEPPRPLQNNFIVGMKIEAVDRKNPFMICPATIGAVCGDQLHITFD 324

Human   208 GWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQP--------------------------------- 239
            ||||||||||.||||||||.||||||||||||
Mouse   325 GWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPPGKIVEKRPRRKRRTRLWRLRTALLGNEEEAPE 389

Human   240 ----PGTSV-------------------------------------------------------- 244
                |||||
Mouse   390 AAEEPGTSVLTFGDENRTLKDCRGEAAEEPGTSAFTFGDENRTLKDCQGGWKKPKGRGFIKPGKD 454

Human   245 ----------------------------------------------------------------- 244

Mouse   455 ETRPGKHDQGAPAGKKPRGRGFTQPLEDEARPGRDVQVAPAEKKRKGKTVTTPWTEDPRLFADQG 519

Human   245 ----------------------------------------------------------------- 244

Mouse   520 DAPAEKKRKGKTVTTPWTEDPRLFADQGDAPAEKKRKGKTVTTPWTEDPRLFADQGAAPAEKKRK 584

Human   245 ----------------------------------------------------------------- 244

Mouse   585 GKTVTTPWTEDPRLFADQGDAPAEKKRKGKTVTTPWTEDPRLFADQGDAPAEKKRKGKTVTTPWT 649

Human   245 ----------------------------------------------------------------- 244

Mouse   650 EDPRLFADQGAAPAEKKRKGKTVTTPWTEDPRLFADQGDAPAEKKRKGKTVTTPWTEDPRLFADQ 714

Human   245 ---PIVK-------------------------------NIAKTESSP------------------ 257
               |..|                               :::.||.:|
Mouse   715 GDAPAEKKPKGKRVTKSRKDQAQFLADEEAMPALFSALSVSSTERTPPSSSEQPKSSTSGKTKST 779

Human   258 SEASQHSMQSPQKTTLILPTQQV-RRSSRIKPPGPTAVPKRSSSVKNITPRKKGPNSGKKEKPLP 321
            |..:|.|.:||:||:::.|..:. :::.:.|..|.|:.||:..::|.:.|:|||..||||||.:|
Mouse   780 SRGAQTSRKSPRKTSVVQPVPKTSKKAGKSKSTGNTSSPKKGITIKIVLPKKKGGKSGKKEKSIP 844

Human   322 VICSTSAASLKSLTRDRGMLYKDVASGPCKIVMSTVCVYVNKHGNFGPHLDPKRIQQLPDHFGPG 386
            ||.|||:|||.:|.:....  ...::||.||||||||||:||||:.||.|||:::||||:|||||
Mouse   845 VISSTSSASLSTLMKSSSS--NKTSAGPSKIVMSTVCVYINKHGDCGPFLDPQKVQQLPNHFGPG 907

Human   387 PVNVVLRRIVQACVDCALETKTVFGYLKPDNRGGEVITASFDGETHSIQLPPVNSASFALRFLEN 451
            ||||:|:|.|||||:||.:.|.||.:||.||||||:|||.|||:.|::|||||||||||||||||
Mouse   908 PVNVILQRTVQACVNCAFQAKDVFLFLKTDNRGGEMITAFFDGKVHTVQLPPVNSASFALRFLEN 972

Human   452 FCHSLQCDNLLSSQPFSSSRGHTHSSAEHDKNQSAKEDVTERQSTKRSPQQTVPYVVPLSPKLPK 516
            ||.||||||.||||||                             :|..|      ||    .|.
Mouse   973 FCQSLQCDNFLSSQPF-----------------------------RREAQ------VP----TPD 998

Human   517 TKEYASEGEPLFAGGSAIPKEENLSEDSKSSSLNSGNYLNPACRNPMYIHTSVSQDFSRSVPGTT 581
            |             |:...|.|| .|..:..||.         |..::.|              .
Mouse   999 T-------------GTDQSKPEN-GEPKEKRSLK---------RLSLHPH--------------R 1026

Human   582 SSPLVGDISPKSSPHEVKFQMQRKSEAPSYIAVPDPSVLKQGFSKDPSTWSVDEVIQFMKHTDPQ 646
            |:|:...:..||.         :.|:|.|||.|||||||||||.|||||||||||||||||||||
Mouse  1027 SAPVSSKVPRKSG---------QASKASSYITVPDPSVLKQGFCKDPSTWSVDEVIQFMKHTDPQ 1082

Human   647 ISGPLADLFRQHEIDGKALFLLKSDVMMKYMGLKLGPALKLCYYIEKLKE 696
            |||||||||||||||||||.||||:::|||||||||||:|||||||||||
Mouse  1083 ISGPLADLFRQHEIDGKALLLLKSELLMKYMGLKLGPAVKLCYYIEKLKE 1132

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCML2	NP_006080.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		5/19 (26%)
		MBT 1	33..131		80/97 (82%)
		MBT	36..131	CDD:214723	78/94 (83%)
		MBT 2	139..240		78/137 (57%)
		MBT	142..240	CDD:214723	75/134 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..320		27/85 (32%)
		DUF3588	356..465	CDD:288954	81/108 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	466..550		14/83 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	575..594		3/18 (17%)
		SAM_Scm	625..696	CDD:188977	64/70 (91%)
		SAM	628..696	CDD:197735	62/67 (93%)
Scml2	XP_006528733.1	MBT	153..248	CDD:214723	78/94 (83%)
		MBT	266..357	CDD:214723	69/90 (77%)
		PTZ00121	<403..>742	CDD:173412	2/338 (1%)
		SLED	877..986	CDD:371916	81/108 (75%)
		SAM_Scm	1062..1132	CDD:188977	64/69 (93%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83962206
Domainoid	1	1.000	186	1.000	Domainoid score	I27502
eggNOG	1	0.900	-	-		E1_KOG3766
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	752	1.000	Inparanoid score	I8549
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40288
OrthoDB	1	1.010	-	-		D111144at7742
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105988
Panther	1	1.100	-	-	LDO	PTHR12247
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2741
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	14.270