DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BTN2A2 and DIP-beta

DIOPT Version :9

Sequence 1:	NP_001184166.1	Gene:	BTN2A2 / 10385	HGNCID:	1137	Length:	523	Species:	Homo sapiens
Sequence 2:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	411	Identity:	93/411 - (22%)
Similarity:	157/411 - (38%)	Gaps:	85/411 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    12 PASLLLLLLLLLLSLC--ALVSAQFTVVG--------PANPILAMVGENTTLRC--------HLS 58
            ||....|||||||..|  ..||.:.:.||        |...:....|.:.|..|        .:|
  Fly    66 PAIRWQLLLLLLLGNCIDLTVSNKISSVGAFEPDFVIPLENVTIAQGRDATFTCVVNNLGGHRVS 130

Human    59 PEKNAEDMEVRWFRSQFSPAVFVYKGGRERTEEQMEEYRGRITFVSKDINRGSVALVIHNVTAQE 123
            .:.::...:|.|.::.....:.::        |.:.....|::....|.|  :..|.|..|..::
  Fly   131 GDGSSAPAKVAWIKADAKAILAIH--------EHVITNNDRLSVQHNDYN--TWTLNIRGVKMED 185

Human   124 NGIYRCYFQ-EGRSYDEAILRLVVAG--LGSKPLIEIKAQEDGSIWLECISGGWYPEPLTVWRDP 185
            .|.|.|... :......|.|.:|:..  :..:...::...|.||..|.|.:.| :|:|...||..
  Fly   186 AGKYMCQVNTDPMKMQTATLEVVIPPDIINEETSGDMMVPEGGSAKLVCRARG-HPKPKITWRRE 249

Human   186 YGEVVPAL----KEVSIADADGLFMVTTAVIIRDK---YVRNVSCSVNNTLLGQEKETVIFIPES 243
            .|..:.|.    ::......:| .|:|.:.|.|.:   |:...|..|..|:..:.|..|.|.|..
  Fly   250 DGREIIARNGSHQKTKAQSVEG-EMLTLSKITRSEMGAYMCIASNGVPPTVSKRMKLQVHFHPLV 313

Human   244 FMPS---ASPWMVALAVI--LTASPWMVSM------TVILA------------VFIIFMAVSICC 285
            .:|:   .:|.:..:.:|  :.|||..::.      .:|:|            ::.|.|   |..
  Fly   314 QVPNQLVGAPVLTDVTLICNVEASPKAINYWQRENGEMIIAGDRYALTEKENNMYAIEM---ILH 375

Human   286 IKKLQREKKILSGEKKVEQE---EKEIAQQLQEELRWRRTFLHAADV-------VLDPDTAHPEL 340
            ||:||...  ..|.|.:.:.   :.|...:|.|..|..:..|...|:       |:..||.
  Fly   376 IKRLQSSD--FGGYKCISKNSIGDTEGTIRLYEMERPGKKILRDDDLNEVSKNEVVQKDTR---- 434

Human   341 FLSED-RRSVRRGPYRQRVPD 360
              ||| .|::....|:.|.||
  Fly   435 --SEDGSRNLNGRLYKDRAPD 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BTN2A2	NP_001184166.1	IG_like	42..146	CDD:214653	18/112 (16%)
		Ig_MOG_like	48..147	CDD:143190	19/107 (18%)
		SPRY_PRY_BTN1_2	326..496	CDD:293991	12/43 (28%)
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	19/120 (16%)
		ig	102..195	CDD:278476	17/102 (17%)
		IG_like	219..307	CDD:214653	22/89 (25%)
		Ig	221..307	CDD:299845	22/87 (25%)
		Ig	311..404	CDD:299845	19/97 (20%)
		IG_like	327..405	CDD:214653	16/82 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910