DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BTN3A3 and Btnl4

DIOPT Version :9

Sequence 1:	NP_008925.1	Gene:	BTN3A3 / 10384	HGNCID:	1140	Length:	584	Species:	Homo sapiens
Sequence 2:	NP_109671.1	Gene:	Btnl4 / 632126	MGIID:	1932036	Length:	586	Species:	Mus musculus

Alignment Length:	498	Identity:	202/498 - (40%)
Similarity:	289/498 - (58%)	Gaps:	17/498 - (3%)

- Green bases have known domain annotations that are detailed below.

Human    12 LNFHV-SLF-LVQLLTPCSAQ-FSVLGPSGPILAMVGEDADLPCHLFPTMSAETM-ELRWVSSSL 72
            |.||| .|| |.|||:..:.| |.|.|||.||:|..|.:|.|||.:||.|:.|.| ||||..|..
Mouse     9 LLFHVPCLFVLTQLLSWVTTQEFRVFGPSDPIVAAPGGEAILPCSVFPAMNVENMEELRWFRSRF 73

Human    73 RQVVNVYADGKEVEDRQSAPYRGRTSILRDGITAGKAALRIHNVTASDSGKYLCYFQDGDFYEKA 137
            .:.|..|.|.:|.::.|...|..||.:::|....|.||:||.||.|||||.|:|:||.|.||::|
Mouse    74 SEAVLFYRDQEEQKEGQMPGYSQRTLLVKDQFHQGTAAVRILNVQASDSGIYICHFQQGVFYDEA 138

Human   138 LVELKVAALGSDLHIEVKGYEDGGIHLECRSTGWYPQPQIKWSDTKGENIPAVEAPV-VADGVGL 201
            ::||||||:||...:.:||.||||:.:.|.::||||:||:.|.|::|||:.|..:.. ..|..||
Mouse   139 ILELKVAAMGSVPEVHIKGPEDGGVCVVCMTSGWYPEPQVHWKDSRGENLTAFSSETHTKDAEGL 203

Human   202 YAVAASVIMRGSSGGGVSCIIRNSLLGLEKTASISIADPFFRSAQPWIAALAGTLPISLLLLAGA 266
            ::....:::|.||...|:|.|.|.:||.||..::.|.:|||..|.||..|...||.:..||:.|.
Mouse   204 FSTETLLVVRDSSVRNVTCSIFNPILGQEKATAMFIPEPFFPQASPWKPAFLVTLTMMGLLVLGT 268

Human   267 SYFLWRQQKEKIALSRETEREREMKEMGYAATEQEISLREKLQEELKWRKIQYMARGEKSLAYHE 331
            ||.|.|:...::.:.:||...:..|:......:..:.....|..|...||..|.|..:|:..|.:
Mouse   269 SYLLRREHSARLKVQQETVNFQREKDESLKTRDDALRTAGALMVERDRRKAAYRAAWKKAQLYAD 333

Human   332 WKMALFKPADVILDPDTANAILLVSEDQRSVQRAEEPRDLPDNPERFEWRYCVLGCENFTSGRHY 396
            |:...|:.....|||.:|:.||.:|.|:.||.|.:....|.|       .:||||....:|||||
Mouse   334 WRKEHFEAWTFTLDPASAHPILAISPDRLSVSRKDSTLCLDD-------LFCVLGIRGISSGRHY 391

Human   397 WEVEV--GDRKEWHIGVCSKNVERKKGWVKMTPENGYWTMGLTDGNKYRALTEPRTN-LKLPEPP 458
            |||::  ||..:|.:|||.:.|:| ||.....|..|:||:|.:... |.|..:..|. |.|.:.|
Mouse   392 WEVKLRNGDSSKWTLGVCREGVDR-KGCFSECPHKGFWTVGRSSSG-YLAYIDTGTALLSLRQAP 454

Human   459 RKVGIFLDYETGEISFYNATDGSHIYTFPHASFSEPLYPVFRI 501
            :.||:|:||..|:|||||.:|.|.:::|..||||..|:|.||:
Mouse   455 QSVGVFVDYTEGDISFYNMSDMSPMFSFHEASFSGTLFPYFRL 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BTN3A3	NP_008925.1	Ig_MOG_like	45..144	CDD:319291	47/99 (47%)
		BaeS	<227..>313	CDD:332495	26/85 (31%)
		SPRY_PRY_BTN3	337..513	CDD:293992	69/168 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	519..584
Btnl4	NP_109671.1	Ig	45..145	CDD:386229	47/99 (47%)
		Ig	<167..233	CDD:386229	25/65 (38%)
		SPRY_PRY_C-I_1	344..497	CDD:293968	67/161 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KB3
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG39342
OrthoDB	1	1.010	-	-		D186278at7742
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X198
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830