DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BTN3A3 and otk2

DIOPT Version :9

Sequence 1:	NP_008925.1	Gene:	BTN3A3 / 10384	HGNCID:	1140	Length:	584	Species:	Homo sapiens
Sequence 2:	NP_612571.1	Gene:	otk2 / 36284	FlyBaseID:	FBgn0267728	Length:	433	Species:	Drosophila melanogaster

Alignment Length:	475	Identity:	113/475 - (23%)
Similarity:	174/475 - (36%)	Gaps:	126/475 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    35 GPSGPILAMVGEDADLPC-HLFPT--MSAETMELRW--VSSSLRQVVNVYADGKEVEDRQSAPYR 94
            ||...|.........||| :..|.  :...::.|||  .|.:||||.....|....|.:.....|
  Fly    38 GPKSSITIKEQSSLQLPCDYQLPDGYLQKSSVILRWRKDSKTLRQVELGRMDSTTSEPQLETMLR 102

Human    95 --GRTSILRDGITAGKAALRIHNVTASDSGKYLCYFQDGDFYEKALVELKVAALGSD---LHIE- 153
              .|.::.:|     ..||:..:|.|||:|:|.|         :.:::..|||..|.   |.||
  Fly   103 EDSRVALSKD-----SGALQFTSVLASDAGQYQC---------QLVIDDSVAASSSSGVLLVIEQ 153

Human   154 --------VKGYEDGGI-HLECRSTGWYPQPQIKWSDTKGENIPAVEAPV-VADGVGLYAVAASV 208
                    .|..|.|.: .:.|::.| .|.||:||  .:...:|   .|| |.|..|      ::
  Fly   154 LKFVPQPTSKNLELGTLSKVHCKAQG-TPAPQVKW--MRETQLP---LPVNVTDQNG------TL 206

Human   209 IMRGSSG---GGVSCIIRNSLLGLEKTASIS-IADPFFR--SAQPWIAALAGTLPISLLLLAGAS 267
            |....|.   |..:||..||...:..|.||: :..|.|.  ...|...|.|||..|....:.
  Fly   207 IFNQVSNEQRGQYTCIASNSQGQITATVSINVVVAPKFSVPPEGPIEVAEAGTAVIHCQAIG--- 268

Human   268 YFLWRQQKEKIALSRETEREREMKEMGYAATEQEISLREKLQEE--LKWRKIQYMARGEKSLAYH 330
                 :.|..|      :.::::..:....|:.|   |..|.|.  |:.|.::....|......
  Fly   269 -----EPKPTI------QWDKDLTYLNENNTDPE---RFSLMENGTLEIRNVRPEDEGRYGCTI- 318

Human   331 EWKMALFKPADVILDPDTANAILLVSEDQRSVQRAEEPRDLPDNPERFEWRYCVLGCENFTSGRH 395
             ...|..|..||          |||.:..:|...:...|.:           .|:.|..|.
  Fly   319 -GSSAGLKREDV----------LLVLKSSKSASNSIVTRII-----------IVIICLAFL---- 357

Human   396 YWEVEVGDRKEW-----HIGVCSKNVERKKGWVKMTPENGYWTMGLTDGNKY------RALTEPR 449
            |:.:.:| .|.|     |:|             |:..|:|: ..|.|||.::      ..|||..
  Fly   358 YFVLVLG-LKVWYRYRRHLG-------------KVQLEDGH-VNGPTDGQEHDHHENEPCLTEAN 407

Human   450 TNLKLPEPPRKVGIFLDYET 469
            ::..|....|:..| |:.|:
  Fly   408 SSKNLKSKLRESTI-LEQES 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BTN3A3	NP_008925.1	Ig_MOG_like	45..144	CDD:319291	26/105 (25%)
		BaeS	<227..>313	CDD:332495	18/90 (20%)
		SPRY_PRY_BTN3	337..513	CDD:293992	32/144 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	519..584
otk2	NP_612571.1	IG_like	41..132	CDD:214653	27/104 (26%)
		I-set	155..238	CDD:254352	26/94 (28%)
		IGc2	175..228	CDD:197706	20/64 (31%)
		IG_like	250..331	CDD:214653	20/109 (18%)
		IGc2	258..323	CDD:197706	13/83 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910