DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BTN3A3 and him-4

DIOPT Version :9

Sequence 1:	NP_008925.1	Gene:	BTN3A3 / 10384	HGNCID:	1140	Length:	584	Species:	Homo sapiens
Sequence 2:	NP_001024582.1	Gene:	him-4 / 181187	WormBaseID:	WBGene00001863	Length:	5198	Species:	Caenorhabditis elegans

Alignment Length:	675	Identity:	138/675 - (20%)
Similarity:	218/675 - (32%)	Gaps:	207/675 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    19 FLVQLLTPCSAQFSVLGPSGPILAMVGEDADLPCHLFPTMSAETMELRWVSSSLRQVVNVYADGK 83
            |.|:::.|.:...|..  ...:.|..||:..|.|   |.......::.||           .||.
Worm  1540 FQVEVIVPLNLDESKY--KKKVFAKEGEEVTLGC---PVSGFPVPQINWV-----------VDGT 1588

Human    84 EVEDRQSAPYRGRTSILRDGITAGKAALRIHNVTASDSGKYLCYFQDGDFYEKALVELKVAA--- 145
            .||..:.  |:|.| :..||:|     |...:|:....|.|.|..|.........|||.|.|
Worm  1589 VVEPGKK--YKGAT-LSNDGLT-----LHFDSVSVKQEGNYHCVAQSKGNILDIDVELSVLAVPI 1645

Human   146 LGSDLHIEVKGYEDGGIHLEC-RSTGWYPQPQIKWSDTKGENIPAVEAPVVADGVGLYAVAASVI 209
            :|.|.::||...:|  |.|.| ..|....:....||....|:.......:.:||..||...|
Worm  1646 VGEDDNLEVFLGKD--ISLSCDLQTESDDKTTFVWSINGSESDRPDNVQIPSDGHRLYITDA--- 1705

Human   210 MRGSSGGGVSCIIRNSLLGLEKTASISI------ADPFFRSAQPWIAALAGTLPI---------- 258
             :..:.|...|.:.||....|:|.::.:      .:|.|.:.|    .|.|..||
Worm  1706 -KPENNGKYMCRVTNSAGKAERTLTLDVLEPPVFVEPVFEANQ----KLIGNNPIILQCQVTGNP 1765

Human   259 ---------------------SLLLL----------------------AGASYFLWRQQKEKIA- 279
                                 ||.||                      |...:|:     :.||
Worm  1766 KPTVIWKIDGNDVDKSWLFDESLSLLRIEKLTGKSAQISCTAENKAGTASRDFFI-----QNIAA 1825

Human   280 --LSRETEREREMKEMGYAATEQEISLREKLQEELKWRKIQYMARGEKSLAY------------- 329
              ...|.::|...:|......:..:||.:   .::.|.| |.:...|....:
Worm  1826 PTFKNEGDQETIFRESETITLDCPVSLGD---FQITWMK-QGLPLTENDAIFTLDNTRLTILNAN 1886

Human   330 --HE---------WKMALFKPADVILD--PDTANAILLVSEDQRSVQRAEE---PRDLPDNP--- 375
              ||         ....:.|..||::.  |...||::.:     .:...||   ..|...||
Worm  1887 RDHEDIYTCVANNTAGQVSKDFDVVVQVLPKIKNAVVTL-----EINEGEEIILTCDAEGNPTPT 1946

Human   376 ERFEWRYCVLGCEN-FTSGRHYWEVEVGDRKEWHIGVCSKNVERKKG--------WVKMTPENGY 431
            .::::....|..|. |.:..|  .|.|.:..::|.||.......|.|        .|:..|.
Worm  1947 AKWDFNQGDLPKEAVFVNNNH--TVVVNNVTKYHTGVYKCYATNKVGQAVKTINVHVRTKPR--- 2006

Human   432 WTMGLTDG----NKYRALTEPRTNLKLPEPPRKVGIFLDYETGEISFYNATDG---------SHI 483
            :..|||:.    |..|::|     |:. :....:|:.:.:......|...|||         .||
Worm  2007 FESGLTESELTVNLTRSIT-----LEC-DVDDAIGVGISWTVNGKPFLAETDGVQTLAGGRFLHI 2065

Human   484 Y---TFPHASFSEPLYPVFRILTLEPTALTICPIPKEVESSPDPDLVPDHSLETPLTPGLANESG 545
            .   |..|.|::                   |.:..|...:     ....:|...:.|.:.||.|
Worm  2066 VSAKTDDHGSYA-------------------CTVTNEAGVA-----TKTFNLFVQVPPTIVNEGG 2106

Human   546 E-PQAEVTSLLLPAHPGAEVSPSAT 569
            | ...|..||:||.....:.:|..|
Worm  2107 EYTVIENNSLVLPCEVTGKPNPVVT 2131

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BTN3A3	NP_008925.1	Ig_MOG_like	45..144	CDD:319291	26/98 (27%)
		BaeS	<227..>313	CDD:332495	22/147 (15%)
		SPRY_PRY_BTN3	337..513	CDD:293992	41/208 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	519..584		13/52 (25%)
him-4	NP_001024582.1	IG_like	442..515	CDD:214653
		IG	527..605	CDD:214652
		Ig	628..694	CDD:319273
		I-set	702..789	CDD:369462
		I-set	793..881	CDD:369462
		Ig	899..974	CDD:386229
		I-set	1012..1081	CDD:369462
		Ig	1109..1172	CDD:319273
		Ig	1196..1263	CDD:319273
		IG_like	1277..1358	CDD:214653
		I-set	1373..1450	CDD:369462
		Ig	1474..1544	CDD:386229	2/3 (67%)
		IGc2	1563..1628	CDD:197706	23/86 (27%)
		Ig	1651..1732	CDD:386229	21/86 (24%)
		Ig	1755..1818	CDD:319273	6/62 (10%)
		Ig	1839..1912	CDD:386229	12/76 (16%)
		Ig	1930..2002	CDD:386229	16/73 (22%)
		IG_like	2014..2095	CDD:214653	17/110 (15%)
		Ig	2094..2182	CDD:386229	12/38 (32%)
		Ig	2190..2283	CDD:386229
		I-set	2296..2380	CDD:369462
		Ig	2384..2471	CDD:386229
		IGc2	2492..2556	CDD:197706
		Ig	2580..2654	CDD:386229
		Ig	2686..2753	CDD:319273
		IG_like	2768..2850	CDD:214653
		I-set	2854..2939	CDD:369462
		IG_like	2951..3031	CDD:214653
		I-set	3046..3116	CDD:369462
		I-set	3127..3213	CDD:369462
		Ig	3217..3292	CDD:386229
		I-set	3300..3386	CDD:369462
		I-set	3396..3472	CDD:369462
		I-set	3481..3569	CDD:369462
		I-set	3591..3663	CDD:369462
		Ig	3667..3762	CDD:386229
		Ig	3775..3848	CDD:386229
		Ig	3859..3947	CDD:386229
		IGc2	3968..4031	CDD:197706
		Ig_3	4045..4119	CDD:372822
		Ig_3	4136..4210	CDD:372822
		Ig	<4262..4314	CDD:386229
		Ig	4318..4406	CDD:386229
		IG_like	4418..4496	CDD:214653
		I-set	4570..4654	CDD:369462
		I-set	4752..4836	CDD:369462
		EGF_CA	4996..5027	CDD:238011
		EGF_CA	5034..5076	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910