Protein Alignment TUBB4A and alphaTub84B

DIOPT Version :10

• Sequence 1: NP_001276052.1
• Gene: TUBB4A / 10382
• HGNCID: 20774
• Length: 495
• Species: Homo sapiens
• Sequence 2: NP_476772.1
• Gene: alphaTub84B / 40848
• FlyBaseID: FBgn0003884
• Length: 450
• Species: Drosophila melanogaster
• Alignment Length: 456
• Identity: 183/456 - (40%)
• Similarity: 272/456 - (59%)
• Gaps: 21/456 - (4%)

Human    52 MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTG------TYHGDSDLQLERINVYYNEATGGNY 110
            |||.:.:..||.|.|||...||:...||||.|.|      |..|..|    ..|.:::|...|.:
  Fly     1 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTVGGGDD----SFNTFFSETGAGKH 61

Human   111 VPRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDAVLDVVRKEA 175
            |||||.|||||..:|.||:|.:.|:|.|:..:.|:..|.||:|:||||.|.|:||.|||.:||.|
  Fly    62 VPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLA 126

Human   176 ESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVVPSPKVSDTVVEPYNATLSV 240
            :.|..||||.:.||.|||||||..:||:.::..::..:....|::.|:|:||..||||||:.|:.
  Fly   127 DQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTT 191

Human   241 HQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLA 305
            |..:|::|..:.:||||:||||.|.|.:..|||.:||.|:...:|.:|..|||.|.||.||.:..
  Fly   192 HTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQ 256

Human   306 VNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRG 370
            .|:||:||:||.:..:||:.|.....:..|:|.|:|...|:..|.|..||||||:|:....::||
  Fly   257 TNLVPYPRIHFPLVTYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYRG 321

Human   371 RMSMKEVDEQMLSVQSKNSSYFVEWIPNNVKTAVCDIPP--------RGLKMAATFIGNSTAIQE 427
            .:..|:|:..:.::::|.:..||:|.|...|..:...||        ..::.|...:.|:|||.|
  Fly   322 DVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAE 386

Human   428 LFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEGEFEEEAEE 492
            .:.|:..:|..|:.::||:|||.||||:|.||:||.   .||.:..:.|::...:.|:.|.|..|
  Fly   387 AWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAR---EDLAALEKDYEEVGMDSGDGEGEGAE 448

Human   493 E 493
            |
  Fly   449 E 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TUBB4A	NP_001276052.1	PLN00220	52..478	CDD:215107	178/439 (41%)
alphaTub84B	NP_476772.1	PTZ00335	1..439	CDD:185562	178/444 (40%)