Protein Alignment TUBB4A and alphaTub67C

DIOPT Version :9

• Sequence 1: NP_001276052.1
• Gene: TUBB4A / 10382
• HGNCID: 20774
• Length: 495
• Species: Homo sapiens
• Sequence 2: NP_524009.2
• Gene: alphaTub67C / 39130
• FlyBaseID: FBgn0087040
• Length: 462
• Species: Drosophila melanogaster
• Alignment Length: 463
• Identity: 183/463 - (39%)
• Similarity: 271/463 - (58%)
• Gaps: 28/463 - (6%)

Human    52 MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTG--------TYHGDS-----DLQLERINVYYN 103
            |||:|.:|.||||.|||...||:...||||:..|        |..|.|     |........::.
  Fly     1 MREVVSIQIGQCGIQIGNACWELYLLEHGINLDGSLKTKEELTASGSSASVGHDTSANDARTFFT 65

Human   104 EATGGNYVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDAVL 168
            |...|..|||::.|||||..:|.||:|...:::.|:..:.|:..|.||:|:|.|:.|.|::|.|.
  Fly    66 ETGNGKQVPRSIFVDLEPTVIDDVRNGCMRELYHPEQLISGKEDAANNYARGRYSIGKEVIDRVT 130

Human   169 DVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVVPSPKVSDTVVEP 233
            ..::|.||.||.||||.:.||||||||||..:||:.::..::..:....|:|.||||||..||||
  Fly   131 SRLQKIAEQCDSLQGFLIFHSLGGGTGSGFTSLLVERLSTDYSKKCKLDFAVYPSPKVSTAVVEP 195

Human   234 YNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLN 298
            |||.|:.|..::::|..:.:||||:||||..:|.:..|.|.:||.|::..:|..|..|||.|.:|
  Fly   196 YNALLTTHSTMDHSDCVFMVDNEAIYDICNNSLGVDRPAYRNLNRLIAQIVSSTTASLRFSGSMN 260

Human   299 ADLRKLAVNMVPFPRLHFFMPGFAPLTS--RGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRY 361
            .||.:...|:|||||:||.:..:|||.|  |.:.:..|:|.  ||...|::.|||..||||.|::
  Fly   261 VDLNEFQTNLVPFPRIHFPLVAYAPLMSAERSAHEQHAITT--LTNACFESSNMMVKCDPRAGKF 323

Human   362 LTVAAVFRGRMSMKEVDEQMLSVQSKNSSYFVEWIPNNVKTAV-----CDIPPRGL---KMAATF 418
            :....::||.:..|:|:..:.:::||....||:|.|...|..:     ..:|...|   ..|...
  Fly   324 MACCMLYRGDVVPKDVNAAVSAIKSKRHIQFVDWCPTGFKIGINYEKPAFVPDGDLAKTSRACCM 388

Human   419 IGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEE 483
            :.|:|||...|..:|.:|..||:::||:|||.||||:|.|||||..|:..|..::::.....|||
  Fly   389 LSNTTAISVAFSNLSYKFDLMFKKRAFVHWYVGEGMEEGEFTEARENIAVLERDFEEVGLDNAEE 453

Human   484 G---EFEE 488
            |   :|:|
  Fly   454 GGDEDFDE 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TUBB4A	NP_001276052.1	PLN00220	52..478	CDD:215107	177/448 (40%)
		beta_tubulin	53..477	CDD:276956	176/446 (39%)
alphaTub67C	NP_524009.2	alpha_tubulin	2..446	CDD:276955	176/445 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810