Protein Alignment TUBA1B and betaTub85D

DIOPT Version :9

• Sequence 1: NP_006073.2
• Gene: TUBA1B / 10376
• HGNCID: 18809
• Length: 451
• Species: Homo sapiens
• Sequence 2: NP_524290.2
• Gene: betaTub85D / 41124
• FlyBaseID: FBgn0003889
• Length: 446
• Species: Drosophila melanogaster
• Alignment Length: 455
• Identity: 184/455 - (40%)
• Similarity: 271/455 - (59%)
• Gaps: 19/455 - (4%)

Human     1 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDD----SFNTFFSETGAGKH 61
            |||.:.|..||.|.|||...||:...||.|...|      |..|..|    ..|.:::|....|:
  Fly     1 MREIVHIQAGQCGNQIGGKFWEVISDEHCIDATG------TYYGDSDLQLERINVYYNEATGAKY 59

Human    62 VPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLA 126
            ||||:.|||||..:|.||:|.:.|:|.|:..:.|:..|.||:|:||||.|.|::|.|||.:||.:
  Fly    60 VPRAILVDLEPGTMDSVRSGAFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKES 124

Human   127 DQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTT 191
            :.|..||||.:.||.|||||||..:||:.::..:|..:....||:.|:|:||..||||||:.|:.
  Fly   125 EGCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSV 189

Human   192 HTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQ 256
            |..:|::|..:.:||||:||||.|.|.:..|||.:||.|:|..:|.:|..|||.|.||.||.:..
  Fly   190 HQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLA 254

Human   257 TNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRG 321
            .|:||:||:||.:..:||:.|.....:..|:|.|:|...|:..|.|..||||||:|:....::||
  Fly   255 VNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAIFRG 319

Human   322 DVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAE 386
            .:..|:|:..:..|:.|.|..||:|.|...|..:...||        ..::.:...:.|:|||.|
  Fly   320 RMSMKEVDEQMLNIQNKNSSFFVEWIPNNCKTAVCDIPP--------RGLKMSATFIGNSTAIQE 376

Human   387 AWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGE-EEGEE 450
            .:.|:..:|..|:.::||:|||.||||:|.||:||..:|..|..:|::....:.:.||| :|.||
  Fly   377 LFKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEATADEEGEFDEDEE 441

Human   451  450
              Fly   442  441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TUBA1B	NP_006073.2	PTZ00335	1..440	CDD:185562	178/442 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	432..451		7/20 (35%)
betaTub85D	NP_524290.2	PLN00220	1..430	CDD:215107	178/442 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810