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Protein Alignment TUBA1B and gammaTub23C

DIOPT Version :10

Sequence 1:	NP_006073.2	Gene:	TUBA1B / 10376	HGNCID:	18809	Length:	451	Species:	Homo sapiens
Sequence 2:	NP_476804.1	Gene:	gammaTub23C / 33501	FlyBaseID:	FBgn0260639	Length:	475	Species:	Drosophila melanogaster

Alignment Length:	471	Identity:	149/471 - (31%)
Similarity:	247/471 - (52%)	Gaps:	31/471 - (6%)

- Green bases have known domain annotations that are detailed below.

Human     3 ECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVF 67
            |.|::.:||.|.|||...|:..||||||.|.|.:  :.....|.|..:.||.:.....::||||.
  Fly     4 EIITLQLGQCGNQIGFEFWKRLCLEHGISPSGVL--EDFANDGLDRKDVFFYQADDDHYIPRAVL 66

Human    68 VDLEPTVIDEVRTGTYRQLFHPEQLITGKE--DAANNYARGHYTIGKEIIDLVLDRIRKLADQCT 130
            :||||.||:.:....|.:|::||.:...|.  .|.||:|.| |:.|:::.:.|.|.|.:.||...
  Fly    67 LDLEPRVINTIMGSVYSKLYNPENVYLSKHGGGAGNNWASG-YSQGEKLQEEVFDIIDREADGSD 130

Human   131 GLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYP-APQVSTAVVEPYNSILTTHTT 194
            .|:||::.||..||||||..|.:||||:..|.||....||::| ..::|..||:||||:||....
  Fly   131 SLEGFILCHSIAGGTGSGMGSFIMERLADRYPKKLIQTFSVFPNQDEISDVVVQPYNSMLTLKRL 195

Human   195 LEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNL 259
            ...:|...::||.|:..|....|.|:.|:::.:|.|:|.|:|..|.:||:...:|.:|......|
  Fly   196 TTAADSVVVLDNTALNRIACDRLHIQNPSFSQINNLVSTIMSVSTTTLRYPSYMNNNLIGLTAPL 260

Human   260 VPYPRIHFPLATYAPVISAEKAYHEQL------SVAEITNACFEPANQMVKCDP---RHGKYMAC 315
            :|.|::||.:..|.|:.|....:.:||      :|.::.....:|.|.||...|   .|..|::.
  Fly   261 IPTPQLHFLMTGYTPLTSDSDIHTQQLVNVRKTTVLDVMRRLLQPKNMMVSTGPDKSNHHCYISI 325

Human   316 CLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSN 380
            ..:.:|:|.|..|:.::..|:.::..||:.|.||..:|.::...|.|.....::.:     ||:|
  Fly   326 LNIIQGEVDPTQVHKSLQRIRDRKMAQFIPWGPTSIQVALSRSSPYVQSNHRVSGL-----MLAN 385

Human   381 TTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGM---EEGEFSEAREDM--------AALEKDYEE 434
            .|:|...:.|..:::|.:..:.||:..:..|.:   :..|..|:||.:        ||..:||.:
  Fly   386 HTSICSLFERALNQYDKLRKRGAFLDQFRREDIFKDDLNELDESRETVDCLVQEYEAATREDYMQ 450

Human   435 VGVDSVEGEGEEEGEE 450
            ..|....|..:.:.|:
  Fly   451 FSVKRGNGPVDSKSED 466

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.