DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HMG20B and Dsp1

DIOPT Version :9

Sequence 1:	NP_006330.2	Gene:	HMG20B / 10362	HGNCID:	5002	Length:	317	Species:	Homo sapiens
Sequence 2:	NP_001138203.1	Gene:	Dsp1 / 117294	FlyBaseID:	FBgn0278608	Length:	397	Species:	Drosophila melanogaster

Alignment Length:	152	Identity:	45/152 - (29%)
Similarity:	73/152 - (48%)	Gaps:	15/152 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    42 EKGSHEEE-----PVKKRGWPKGKKRKKIL-PNGPKAPVTGYVRFLNERREQIRTRHPDLPFPEI 100
            :|..:|.|     |.|.....:|||||:|. ||.||..::.:..|.|:.|.:::..:|:....:|
  Fly   241 DKQRYEAEMQNYVPPKGAVVGRGKKRKQIKDPNAPKRSLSAFFWFCNDERNKVKALNPEFGVGDI 305

Human   101 TKMLGAEWSKLQPTEKQRYLDEAEREKQQYMKELRAYQQSEAYKMCTEKIQEKKIKKEDSSSGLM 165
            .|.||.:||.:.|..||:|...|||:|.:|.:|:..|:.|....|....:| ..::.:...:.|:
  Fly   306 AKELGRKWSDVDPEVKQKYESMAERDKARYEREMTEYKTSGKIAMSAPSMQ-ASMQAQAQKAALL 369

Human   166 --------NTLLNGHKGGDCDG 179
                    ..|...|...|.||
  Fly   370 AAAAQQQHQQLEEQHDDDDGDG 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HMG20B	NP_006330.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71		13/34 (38%)
HMG20B	NP_006330.2	HMGB-UBF_HMG-box	70..135	CDD:238686	22/64 (34%)
Dsp1	NP_001138203.1	HMG-box	182..252	CDD:294061	3/10 (30%)
Dsp1	NP_001138203.1	HMGB-UBF_HMG-box	275..339	CDD:238686	21/63 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3288
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840