DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA9 and Eato

DIOPT Version :9

Sequence 1:XP_024306297.1 Gene:ABCA9 / 10350 HGNCID:39 Length:1634 Species:Homo sapiens
Sequence 2:NP_001036360.1 Gene:Eato / 34783 FlyBaseID:FBgn0028539 Length:1597 Species:Drosophila melanogaster


Alignment Length:1729 Identity:424/1729 - (24%)
Similarity:741/1729 - (42%) Gaps:303/1729 - (17%)


- Green bases have known domain annotations that are detailed below.


Human    21 WALLCKNCLKKWRMKRQTLLEWLF---SFLLVLFLYLFFS---NLHQVHDTPQMSSMDLGRVDSF 79
            :..|.||.|    ..::.||..|.   .|..||..||.:|   .|||::.....:.|.| |...|
  Fly    10 FVFLRKNLL----YLQRNLLPLLLICSGFAGVLTAYLHWSVKPVLHQINQFEAKNEMVL-RELYF 69

Human    80 --NDTNYVIAFAPESKTTQEIMNKVASAPFLKGRTIMG------WPDEKSMD-ELDLN------- 128
              |:.:| |.::|.|...::||:.:        |..:|      .|:..|.: :|::.       
  Fly    70 PGNELDY-IYYSPISPNVEDIMDLL--------RVDLGIIPERLRPNNNSFEMQLEMEQQCRGSC 125

Human   129 YSIDAVRVIFTDT---FSYHLKFSWGHRIPMMKEHRDHSAHCQAVNEKMKCEGSEFWEKGFVAFQ 190
            ::||..||....:   |.|.|..:.....|..:...|...:.|       .:..::...||::.|
  Fly   126 FAIDFHRVPNRGSDRKFRYSLSSNQMRISPRKRFVNDEEIYHQ-------IDDDDYIRSGFLSLQ 183

Human   191 AAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFF-----IFFCIISFSTFIYYVS 250
            ..::...::........|.::|    .|..:..::.......:|     |.|.::..|:|:    
  Fly   184 HILDKQYMKYQELGKDFEVVVS----SMPNMEVISMDSHRLTYFGTLCSILFNVVLLSSFV---- 240

Human   251 VNVTQERQ-----YITSLMTMMGLRESAFWLSWGLMYAGFILIMATLMALIVKSAQIVVLTGFVM 310
            |...:|:|     ::..:..|..|....|:|...:.|. .::|...::|.:.|:...:.   |..
  Fly   241 VPFVEEKQNGLKEFLNLVTPMSFLNGLTFFLIRFVCYT-LLMIFVLVVAYLYKALGSIC---FAY 301

Human   311 VFTLFLLYGLSLITLAFLMSVLIKKPF------LTGLVV---FLLIVFWGI-LGFPALYTRLPAF 365
            |..|||||.||.::.|:|:|:.....|      |..|::   |..:..|.. |.|....|.  .|
  Fly   302 VAVLFLLYILSTMSYAYLISICFHSVFYAKIGGLAMLIIPYAFSFVRSWATSLAFVCFSTN--TF 364

Human   366 LEWTLCLLSPFA-----FTVGMAQLIHLDYDVNSNAHLDSSQNPYLIIATLF----MLVFDTLLY 421
            || .|.:...|:     ...|...:..:   :.||:            :|:|    :|||.:.||
  Fly   365 LE-GLDIFQTFSNKRKNREFGAVDVFRV---IKSNS------------STMFSVYVVLVFQSFLY 413

Human   422 LVLTLYFDKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDPTPNDCFEPVSPEFCGK 486
            .:|..|...:.|...|.:....|||....:.:..|       ||..:.|.             |.
  Fly   414 AMLYNYLGCVFPGPGGLKRPMFFFLDPKTYMKRQR-------NEYTTTPR-------------GT 458

Human   487 EAIRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTV 551
            .||.|..|.|::............:...|...:||.||||:||||||::|::.||....||.:.|
  Fly   459 HAIIITELCKKFQTSKRDTLISDNLNMTINNKEITVLLGHNGAGKTTMMNMIMGLVPKDSGKIIV 523

Human   552 YNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEME 616
            .:.     .|:.:.....|||||.:|...::|..::|..||:::|....:........:::|.:.
  Fly   524 CSE-----RDVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDARDWADEKLKKLGLS 583

Human   617 NIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDRVILFST 681
            :.::...:|||||..|:|:.||||.|:.::::||||::|||..||..:|::|...:.::.:|.:|
  Fly   584 DKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILLNLRKEKAVLVTT 648

Human   682 QFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNERCDPE-SITSLVKQHISDA 745
            .:::||::|.|....::||||:..||.|.||:|.||||.|.|.:|:....| .|..::...:..|
  Fly   649 HYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKLEINDFTSREVEIMEIIHHFVPTA 713

Human   746 KLTAQSEEKLVYILPLERTNKFPE-LYRDLDRCSNQGIEDYGVSITTLNEVFLKLEGKSTIDESD 809
            ::.......:...||....|.|.: |||........||....::.|:|.:|||:..|     |.|
  Fly   714 RVLNVVNPTVYICLPYAYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLRCAG-----EQD 773

Human   810 IGIWGQLQT-DGAKDIGSLVELEQVLSSFHETRKTISGVALWRQQVCAIAKVRFLKLKKERKSLW 873
                 |:.| ||:::...|:...:.|.. |...:.:  ..||    .|:...::..:..|  .|:
  Fly   774 -----QVDTPDGSRNDAPLLAHYKRLQD-HPPHRGL--FQLW----MAVFYKKWTFISNE--WLY 824

Human   874 TILLL-------FG---ISFIPQLLEHLFYESYQKSYPWELS-----------PNTYFLSPGQQP 917
            |:::|       ||   :.....|:|:      :::.|.:||           |..:.....||.
  Fly   825 TLIMLCIPFVCVFGAILVMHAMSLVEN------EEALPLKLSQMGSGVIYVHNPTGHHAHLEQQL 883

Human   918 QDPLTHLLVINKT----GST-IDNFLHSLRRQNIA--IE-----VDAFGTRNGTDD-PSYNGAII 969
            :..:....:..||    ||. :.|....|:|.|:|  :|     :|.:|...||.| |:..  |.
  Fly   884 RQQIELNGITAKTMHLRGSNDVKNESLDLQRDNLADFLEQVIGIIDMYGGGRGTSDTPTIE--IF 946

Human   970 VSGDEKDHRFSIACNTKRLNCFPVLLDVISNGLLGIFNSSEHIQTDR-------STFFEEHMDYE 1027
            .||:             |.:....|::::.:.:|.:......|.|..       |......::| 
  Fly   947 YSGN-------------RYHSSVELINLVDSAMLKLGRPESEIDTTYVPIRRFVSDISPSRLEY- 997

Human  1028 YGYRSNTFFWIPMAASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLYFLILLL 1092
            |.      ..:|:...|..:..:|.  .:::.|:...::..:....|||.....|:.:...:.:.
  Fly   998 YA------VIVPIGMFFFMFYFISL--PFREYANGFKQLQTMSRFTYWFAHFTFDMLILIFVCVA 1054

Human  1093 MQIMDYIFSPEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRNGRKNSGIWSFFFLIVVIF 1157
            :..:..:..|.| ::....|.:.:|....|..|.:.:.|.:.   .|.:..|.|.::..|::::.
  Fly  1055 LFSLQSLMMPSE-LYTTAELKVIVLSIFFYGCSYLPILYALG---NNFKSISTISTYLLLMLIVS 1115

Human  1158 SI---------VATDLNEYGFLGLFFGTMLIPPFTLIGSLFIFSE-----ISPDSMDYLGASESE 1208
            :|         .|..|:|.....|.|    :|.|.|.....|.:|     ..|..:..|.:.::.
  Fly  1116 AIAPLITSSNAAAMKLHETKIAFLCF----LPDFNLNHQFRIINENFITRRHPALIKGLISQDTF 1176

Human  1209 IVYLALLIPYLHFLIFLFILRCLEMNCRKKLMRK--DPVFRIS---PRSNAIFPNPEEPEGEEED 1268
            ..| |..:..:....|..:|.      .|.|.|:  |.::..:   .:.|:....|..|..|.:|
  Fly  1177 FAY-ATAVGVMVMAFFTIVLE------HKYLRRRIHDGIWEWAFQRKKYNSTGTLPSTPISEIDD 1234

Human  1269 IQMERMRTVNAMAVRDFDETPV----IIASCLRKEYAGKKKNCFSKRKKKIATRNVSFCVKKGEV 1329
            ...|..|      |.|..:.|:    :|...|||.|.           .|:|...|||...:||.
  Fly  1235 CAREEKR------VTDLIKDPLNDHSLIVHNLRKRYG-----------DKLAVDGVSFAAAQGEC 1282

Human  1330 IGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEP----LGFLGYCPQENALWPNLTVRQH 1390
            .||||.|||||::|.:||..:.....|.:.:||:...|.    ..:.|||||.:||...:|..|.
  Fly  1283 FGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKGADIREHELKYREYFGYCPQYDALNKFMTAEQC 1347

Human  1391 LEVYAAVKGL--RKGDAMIA----ITRLVDALKLQDQLKAPVKTLSEGIKRKLCFVLSILGNPSV 1449
            |...|.::||  |:.|...:    :...::.:.|....|..|:..|.|.||||...::::|.|::
  Fly  1348 LYYMALLRGLSRRRTDGPASCKEHVKYWLEKMHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPAL 1412

Human  1450 VLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQ 1514
            ||||||:||:||..::.:||.|: .|:..:|..:||:|.|.|.|.:|:|:|||..|:.:|:.:|.
  Fly  1413 VLLDEPTTGVDPISRRFLWQCIK-DFQGKDRTVVLTSHSMDECEELCNRLAIMAHGKFKCLNNIC 1476

Human  1515 HLKSKFGKDYLLEMKLKNLAQME------PLHAEILRLFPQAAQQERFSSLMVYKLPVEDVRPLS 1573
            .||...|....|:||.....:|.      .|.:|    ||....:|..:..:.|.:..::...|.
  Fly  1477 ALKRLSGFTIKLKMKADTETEMNVSTITGTLKSE----FPGLELRESHAGTLTYFVSTQESVVLW 1537

Human  1574 QAFFKL--EIV--KQSFDLEEYSLSQSTLEQVFLELSKE 1608
            .:.||:  |.:  :.|..:.:||:::.|||.:||:..:|
  Fly  1538 SSVFKIAEEYLGDRLSALVADYSVNECTLEDIFLKFERE 1576

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCA9XP_024306297.1 ABC2_membrane_3 53..416 CDD:315386 85/413 (21%)
AAA <245..1609 CDD:333001 372/1475 (25%)
EatoNP_001036360.1 ABC2_membrane_3 <209..347 CDD:289468 32/145 (22%)
CcmA 460..767 CDD:224054 99/311 (32%)
ABC_subfamily_A 461..679 CDD:213230 72/222 (32%)
ABC2_membrane_3 <937..1117 CDD:289468 33/207 (16%)
ABC_subfamily_A 1255..1479 CDD:213230 83/235 (35%)
drrA 1262..1573 CDD:130256 105/326 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148379
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.650

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