Protein Alignment ABCA10 and snu

DIOPT Version :10

• Sequence 1: NP_525021.3
• Gene: ABCA10 / 10349
• HGNCID: 30
• Length: 1543
• Species: Homo sapiens
• Sequence 2: NP_651628.1
• Gene: snu / 43391
• FlyBaseID: FBgn0039594
• Length: 808
• Species: Drosophila melanogaster
• Alignment Length: 807
• Identity: 167/807 - (20%)
• Similarity: 302/807 - (37%)
• Gaps: 226/807 - (28%)

Human   380 PVSPEFHGKEAIRIRNVIKEYNGKTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLS 444
            |.:...:.:.|:.:|:..|.|..|....:.|..:...:.:|.|..:||.:|.||:|||:.:.|..
  Fly    63 PANGPRNTQAAVSVRHAFKAYGKKKNANQVLNNLNMTVPKGTIYGLLGASGCGKTTLLSCIVGRR 127

Human   445 VSTEGSATIY----NTQLSEITDMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVE 505
            ....|...:.    .|:.|.:..     |.:|:.||....:...:::|.:..|..|.|:..||:.
  Fly   128 YMDAGEIFVLGGKPGTRGSGVPG-----KRVGYMPQEIALYGEFSIQETMMYFGWIFGMDTKEIL 187

Human   506 QEVKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLL 570
            :.::.::..||:.|.:.:: |.|||||:|:::..:|::.||::|:|||||.|:||..|..:|:
  Fly   188 ERLQFLLNFLDLPSEKRLV-KNLSGGQQRRVSFAVALMHDPELLILDEPTVGVDPLLRQSIWN-- 249

Human   571 KEHKV------DRLILFSTQFMDEA------------DILADRKVFLSNGKLKCAG-SSLFLKRK 616
              |.|      .:.::.:|.:::||            .:||:....:.....||.. ..:|||
  Fly   250 --HLVHITKAGQKTVIITTHYIEEARQAHTIGLMRSGHLLAEESPSVLLSIYKCISLEEVFLK-- 310

Human   617 WGIGYHLSLHRNEMCDTEKI--TSLIKQHIPDAKLTTESEEKLVYSLPLEKTNKFPDLYSDLDKC 679
                  ||..:::..|...:  ::.|..|            .:.:...::|.:.
  Fly   311 ------LSRIQSQKGDVTHVNFSNNISLH------------AMAFGSKMDKPSS----------- 346

Human   680 SDQGIRNYAVSVTSLN-----EVFLNLEGKS--AIDEPDFDIGKQEKIHVTRNTGDESEMEQV-- 735
            |.:|      .|..||     ||.:|....|  .:::..:......:   ..|..||...:..
  Fly   347 SQEG------GVVGLNFHQSKEVLINDSNGSIYTLNQEPYSPPPSRR---NNNPNDEESCQDCYS 402

Human   736 -LCSLPETRKAVSSAAL-------WRRQ-----IYAVATLRFLKLRRERRALLCLLL-----VLG 782
             ||.:  |.|....|.|       ||..     |:|:..::.:        |.||.:     .|.
  Fly   403 NLCKI--TSKGKIRALLTKNMLRMWRNVGVMLFIFALPVMQVI--------LFCLAIGRDPQGLN 457

Human   783 IAFIPIILEKIMYKVTRETHCWEFSPSMYFLSL---------EQIPKTPLTSLLIVNNTGSNIED 838
            :|    |:...|....||...||  ...:|.:|         ..:.||....|       .:.::
  Fly   458 LA----IVNGEMNDTVRENCYWE--DGCHFKNLGCRYLSHLNTSVVKTYYEDL-------DDAKE 509

Human   839 LVHSLKCQDIVLEIDDFRN---------RNGSDDPSYNGAIIVSGDQKDYRFSVACNTK-KLNCF 893
            .|........|...::|.:         |:..|:...:..:.|..|..:.:..|..|.. :|...
  Fly   510 AVRKGTAWGAVYISENFTDAFIARANLGRDSDDETIDSSEVKVWLDMSNQQIGVMLNRDIQLAFR 574

Human   894 PVLMGIV----SNALMG--IFNFTELI----QMESTSFSRDDIVLDLGFIDGSIFLLLITNCVSP 948
            ...||::    ||..:|  ...|.:.|    ....|.|....::|.:      :|.|.:.
  Fly   575 DFAMGLLGQCGSNPKLGDVPIQFRDPIYGTMNPSFTDFVAPGVILTI------VFFLAVA----- 628

Human   949 FIGMSSISDYKKNVQSQLWISGLWPSAYWCGQALVDIPLYFLILFSIHLIYYFIFLGFQLSWELM 1013
            ....:.|.:..:.:..:.|::|:.|               |.|||| |:|..|:.:..|.:..|:
  Fly   629 LTSSALIIERTEGLLDRSWVAGVSP---------------FEILFS-HVITQFVVMCGQTTLVLI 677

Human  1014 FVLVVCIIGCAVSLIFLTYVLSFIFRKWRKNNG--FW-------------SFGFFIILICVSTIM 1063
            |:|||..:                     .|||  ||             .|||.|..:|
  Fly   678 FMLVVFGV---------------------TNNGDLFWVIVLTLLQGMCGMCFGFLISSVC----- 716

Human  1064 VSTQYEKLNLILCM-IFIPSFTLLGYV 1089
               :.|:..:.|.: .|.|:..|.|.:
  Fly   717 ---ELERNAIQLALGSFYPTLLLSGVI 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA10	NP_525021.3	rim_protein	<37..1520	CDD:130324	167/807 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1153..1177
snu	NP_651628.1	CcmA	74..311	CDD:440746	65/254 (26%)
		YadH	609..807	CDD:440604	39/188 (21%)