DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCA10 and Eato

DIOPT Version :9

Sequence 1:NP_001364250.1 Gene:ABCA10 / 10349 HGNCID:30 Length:1543 Species:Homo sapiens
Sequence 2:NP_001036360.1 Gene:Eato / 34783 FlyBaseID:FBgn0028539 Length:1597 Species:Drosophila melanogaster


Alignment Length:1597 Identity:384/1597 - (24%)
Similarity:667/1597 - (41%) Gaps:326/1597 - (20%)


- Green bases have known domain annotations that are detailed below.


Human    83 YWLKGFVAFQAAINAAIIEVTTNHSVMEELTSVIGINMKIPPFISKGEIMNEWFHFTCLVSF--- 144
            |...||::.|..::...::........|.:.|.:. ||::   ||.......:|...|.:.|   
  Fly   174 YIRSGFLSLQHILDKQYMKYQELGKDFEVVVSSMP-NMEV---ISMDSHRLTYFGTLCSILFNVV 234

Human   145 --SSFIY-FASLNVARERG--KFKKLMTVMG-LRESAFWLSWGLTYICFIFIMSIFMALVITSIP 203
              |||:. |..   .::.|  :|..|:|.|. |....|:|   :.::|:..:| ||:.:|.....
  Fly   235 LLSSFVVPFVE---EKQNGLKEFLNLVTPMSFLNGLTFFL---IRFVCYTLLM-IFVLVVAYLYK 292

Human   204 IVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPMLAGLAGFLFTVFWGCLGFTVLYRQLPLSL 268
            .:....|..:..|:.||.||.::.|:|:|:.......|.:.|....:             :|.:.
  Fly   293 ALGSICFAYVAVLFLLYILSTMSYAYLISICFHSVFYAKIGGLAMLI-------------IPYAF 344

Human   269 GWVLSLLSPFAFTAGMAQITHLDNYLSGV-------------------IFPDPSGDSYKMIATFF 314
            .:|.|..:..||..     ...:.:|.|:                   :|.....:|..|.:.:.
  Fly   345 SFVRSWATSLAFVC-----FSTNTFLEGLDIFQTFSNKRKNREFGAVDVFRVIKSNSSTMFSVYV 404

Human   315 ILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWSKHQNTHHEIFENEINPEHSSDDSFE 379
            :|.|.:..|.:...|...|.|...|......|||....:.|.|...:                  
  Fly   405 VLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFFFLDPKTYMKRQRNEY------------------ 451

Human   380 PVSPEFHGKEAIRIRNVIKEYNGKTGKVEAL--QGIFFDIYEGQITAILGHNGAGKSTLLNILSG 442
            ..:|  .|..||.|..:.|::  :|.|.:.|  ..:...|...:||.:||||||||:|::|::.|
  Fly   452 TTTP--RGTHAIIITELCKKF--QTSKRDTLISDNLNMTINNKEITVLLGHNGAGKTTMMNMIMG 512

Human   443 LSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQE 507
            |.....|...:.:.:     |:...|..||||||.:....::|..::|..||:::|....:....
  Fly   513 LVPKDSGKIIVCSER-----DVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDARDW 572

Human   508 VKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKE 572
            ....:.:|.:...::...|.||||.||:|:|||||.|:.::::||||::|||..||..:|.:|..
  Fly   573 ADEKLKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILLN 637

Human   573 HKVDRLILFSTQFMDEADILADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLHRNEMCDTE-KI 636
            .:.::.:|.:|.:|:||::|.|....|:||||:..||.|.||||.||||.|.|..|:....| :|
  Fly   638 LRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKLEINDFTSREVEI 702

Human   637 TSLIKQHIPDAKLTTESEEKLVYSLPLEKTNKFPDLYSDLD-KCSDQGIRNYAVSVTSLNEVFLN 700
            ..:|...:|.|::.......:...||....|.|..:...|: :..:.||...:::.|||.:|||.
  Fly   703 MEIIHHFVPTARVLNVVNPTVYICLPYAYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLR 767

Human   701 LEG-KSAIDEPDFDIGKQEKIHVTRNTGDESEMEQVLCSLPETRKAVSSAALWRRQIYAVATLRF 764
            ..| :..:|.||          .:||........:.|...|..|....   ||....|...|  |
  Fly   768 CAGEQDQVDTPD----------GSRNDAPLLAHYKRLQDHPPHRGLFQ---LWMAVFYKKWT--F 817

Human   765 LKLRRERRALLCLLLVLGIAFI----PIILEKIMYKVTRETH------------CWEFSPSMYFL 813
            :.     ...|..|::|.|.|:    .|::...|..|..|..            .:..:|:.:..
  Fly   818 IS-----NEWLYTLIMLCIPFVCVFGAILVMHAMSLVENEEALPLKLSQMGSGVIYVHNPTGHHA 877

Human   814 SLEQIPKTPLTSLLIVNNT----GSNIEDLVHSLKCQDIVLEIDDFRN---------------RN 859
            .|||..:..:....|...|    |||      .:|.:.:.|:.|:..:               |.
  Fly   878 HLEQQLRQQIELNGITAKTMHLRGSN------DVKNESLDLQRDNLADFLEQVIGIIDMYGGGRG 936

Human   860 GSDDPSYNGAIIVSGDQKDYRFSVACNTKKLNCFPVLMGIVSNALMGIFNFTELIQMESTSFSRD 924
            .||.|:..  |..||::  |..||.           |:.:|.:|::              ...|.
  Fly   937 TSDTPTIE--IFYSGNR--YHSSVE-----------LINLVDSAML--------------KLGRP 972

Human   925 DIVLDLGFIDGSIFLLLITNCVSPFIGMSSISDYKKNVQSQLWISGLWPSAYWCGQALVDIPLYF 989
            :..:|..:                             |..:.::|.:.||.......:|.|.::|
  Fly   973 ESEIDTTY-----------------------------VPIRRFVSDISPSRLEYYAVIVPIGMFF 1008

Human   990 LILFSIHLIYYFIFLGFQ---------------------LSWELMFVLVVCI------------- 1020
                   .::|||.|.|:                     .:::::.::.||:             
  Fly  1009 -------FMFYFISLPFREYANGFKQLQTMSRFTYWFAHFTFDMLILIFVCVALFSLQSLMMPSE 1066

Human  1021 ------IGCAVSLIFLTYVLSFIFRKWRKNNGFWSFG----FFIILICVSTI---MVSTQYEKLN 1072
                  :...|..||. |..|::...:...|.|.|..    :.::::.||.|   :.|:....:.
  Fly  1067 LYTTAELKVIVLSIFF-YGCSYLPILYALGNNFKSISTISTYLLLMLIVSAIAPLITSSNAAAMK 1130

Human  1073 L----ILCMIFIPSFTLLGYVMLLIQLDFM-RNLDSLDNRINEVNKTILLTTLIPYLQSV---IF 1129
            |    |..:.|:|.|. |.:...:|..:|: |...:|      :...|...|...|..:|   :.
  Fly  1131 LHETKIAFLCFLPDFN-LNHQFRIINENFITRRHPAL------IKGLISQDTFFAYATAVGVMVM 1188

Human  1130 LFVIRCLEMKYGNEIMNKDPVFRIS---PRSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLE 1191
            .|....||.||....:: |.::..:   .:...|...|..|..|.:|...|..:..:.:..| |.
  Fly  1189 AFFTIVLEHKYLRRRIH-DGIWEWAFQRKKYNSTGTLPSTPISEIDDCAREEKRVTDLIKDP-LN 1251

Human  1192 EEPVITASCLHKEYYETKKSCFSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCT 1256
            :..:|..: |.|.|.:           |:|:..|||...:||..||||.|||||:::.:||....
  Fly  1252 DHSLIVHN-LRKRYGD-----------KLAVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAANL 1304

Human  1257 KPTAGVVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKE--DAALS 1319
            ....|.:.::|  |.:|:......::.|||||.::|...:|.::.|...|.::||.:.  |...|
  Fly  1305 PLDGGTIRIKG--ADIREHELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPAS 1367

Human  1320 ----ISRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQ 1380
                :...:|.:.|.:..|..|:..|.|.||||...::::|.|::||||||.||:||..::.:||
  Fly  1368 CKEHVKYWLEKMHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQ 1432

Human  1381 ILQATVKNKERGTLLTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMKEPT 1445
            .:: ..:.|:|..:||:|.|.|.|.:|:|:|:|..|..:|:.:|..||...|  :.:::|||..|
  Fly  1433 CIK-DFQGKDRTVVLTSHSMDECEELCNRLAIMAHGKFKCLNNICALKRLSG--FTIKLKMKADT 1494

Human  1446 QVE---ALHTEILKL-FPQAAWQERYSSLMAYKLPVEDVHPLSRAFFK---------LEAMKQTF 1497
            :.|   :..|..||. ||....:|.::..:.|.:..::...|..:.||         |.|:    
  Fly  1495 ETEMNVSTITGTLKSEFPGLELRESHAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRLSAL---- 1555

Human  1498 NLEEYSLSQATLEQVFLELCKEQELGNVDDKIDTTVE 1534
             :.:||:::.|||.:||:.  |:|..:......|:|:
  Fly  1556 -VADYSVNECTLEDIFLKF--EREAKSQSTSRQTSVQ 1589

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCA10NP_001364250.1 rim_protein <37..1520 CDD:130324 380/1581 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1153..1177 5/26 (19%)
EatoNP_001036360.1 ABC2_membrane_3 <209..347 CDD:289468 36/160 (23%)
CcmA 460..767 CDD:224054 105/313 (34%)
ABC_subfamily_A 461..679 CDD:213230 76/224 (34%)
ABC2_membrane_3 <937..1117 CDD:289468 38/245 (16%)
ABC_subfamily_A 1255..1479 CDD:213230 78/238 (33%)
drrA 1262..1573 CDD:130256 103/331 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148340
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.650

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