Protein Alignment ABCA7 and osy

DIOPT Version :10

• Sequence 1: NP_061985.2
• Gene: ABCA7 / 10347
• HGNCID: 37
• Length: 2146
• Species: Homo sapiens
• Sequence 2: NP_001034071.1
• Gene: osy / 43186
• FlyBaseID: FBgn0053970
• Length: 777
• Species: Drosophila melanogaster
• Alignment Length: 994
• Identity: 199/994 - (20%)
• Similarity: 337/994 - (33%)
• Gaps: 339/994 - (34%)

Human   779 PPKSPAPCPTPLDPKV-------LVEEAPPGLS----PGVSVRSLEKRFPGSPQP--ALRGLSLD 830
            ||.:||...|..:..:       |....|..|:    ..|.||...|.:..|..|  .|.||::.
  Fly     9 PPTAPAATATTANSDLDLAARRRLFISQPSTLATRRQQAVCVRRAHKMYGSSKNPNVVLDGLNMT 73

Human   831 FYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAI-RPHLGVCPQYNVLFD 894
            ..:|.|...||.:|.||||.||.:.|....:.|..::||....|..:.: .|.:|..||...|:.
  Fly    74 VPKGSIYGLLGASGCGKTTLLSCIVGRRRLNSGEIWVLGGRPGSRGSGVPGPRIGYMPQEIALYG 138

Human   895 MLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQ 959
            ..|:.|.:.::|.:..:|...:....:.||:.:.| ...|...::||||.||::|:|:|.:...:
  Fly   139 EFTMRETLIYFGIISAMSKGDIEDRTEFLLKLLNL-PNASKFVKNLSGGQQRRVSLAVALLHEPE 202

Human   960 VVILDEPTAGVDPASRRGIWELLLKYREG--RTLILSTHHLDE---AELLGDRVAVVAGGRLCCC 1019
            ::||||||.||||..|:.||:.|:...:.  .|:|::||::||   |.::|    ::.||::...
  Fly   203 LLILDEPTVGVDPVLRQSIWDHLVDITKNGHTTVIITTHYIDECAQAHMIG----LLRGGKMLAE 263

Human  1020 GSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQH 1084
            .||.:||:...:               :...|..::                       |:::|:
  Fly   264 ESPDYLRQQYNA---------------DSLEDVFLK-----------------------LSVLQN 290

Human  1085 WVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEIFLKVVEE 1149
            .  |.|....:..|:|                                       |::.:..:..
  Fly   291 M--GKRRRSSIAQEIV---------------------------------------EQVTVPAISN 314

Human  1150 CAADTDME------DGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETDQGSGPDAV 1208
            .|.|...|      .|..|.::....|..|       |...||     ||  ||...    |...
  Fly   315 PALDMSDEQHAAEISGEFGDNISMSSAARD-------PISTTA-----PA--APPLP----PPQE 361

Human  1209 GRVQGW----ALTRQQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIVPPFGHYPAL 1269
            .....|    .:....|.||:.|.||...|:       :.:....|||.:|
  Fly   362 IPTSFWYNLHVMQSHHLHALIWKNFLWMMRN-------VGVMLFIVGLPVV-------------- 405

Human  1270 RLSPTMYGAQVSFFSEDAPGDPGRARLLEALLQEAGLEEPPVQHSSHRFSAPEVPAEVAKVLASG 1334
                     |:..|......||...:|..|               :|..|...:..:.
  Fly   406 ---------QILLFCYAIGHDPTGLKLAVA---------------NHEMSGEMIMEQF------- 439

Human  1335 NWTPESPSPACQCSRPGARRLLPDCPAAAGGPPPPQAVTGSGEVVQNLTGRNLSDFLVKTYPRLV 1399
                                    ||..          ||..:.:  |:.|.| |.|||....:|
  Fly   440 ------------------------CPVH----------TGCNQTM--LSCRYL-DMLVKNKSMVV 467

Human  1400 RQGLKTKKWVNEVRYGGFSLGGRDPGLPSGQELGRSVEELWALLSPLP---GGALDRVLKNLTAW 1461
            :.....:....|||.|                      ..||.|...|   ...::||.....|.
  Fly   468 QYVTDDEMAYEEVRKG----------------------RAWAALVIQPNYTASLMERVEDGRYAE 510

Human  1462 AHSLDAQD-SLKIWFNNKGWHSMV------AFVNRASNAILRAHLPPG----PARHAHSITTLNH 1515
            ..::::.| ::::.::|:....::      .|.|...:.:....:.|.    |....|.:....:
  Fly   511 DGTIESSDLAVRMDWSNQQISQLLYRDLQYTFFNFVGDMLSDCDVNPKLGRVPVDFQHPVYGYRN 575

Human  1516 PLNLT---------------KEQLSEGALMASSVDVLVSICVV-------FAMSFVPASFTLVLI 1558
            | |.|               ...::.||::....:.::..|:|       ..:|.|...||::|.
  Fly   576 P-NFTDFAAPGVILTIIFFLAVAVTSGAMLIDRNEGMLERCLVAGITGPEILLSQVVTQFTVMLS 639

Human  1559 EERVTRAK-----HLQLMGGLSPTLYWLGNFLWDMCNYLVPACIV-VLIFLAF-----------Q 1606
            :.......     .|.|:|.:     ||          :|..||: .|..::|           :
  Fly   640 QTTFVLIVSFYFFELTLVGNI-----WL----------VVALCILNGLCGMSFGFVISCAVDTER 689

Human  1607 QRAYVAPAN-LPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLT------------------ 1652
            ...|||..: ||.::|..::  |.|.. |:|...||    ||::.||
  Fly   690 TATYVAMGSFLPIVMLCGII--WPIEG-MFPLLQFF----TAFLPLTKPTESMRSILQRGWGIDN 747

Human  1653 --CINLFIGINGSMATFVL 1669
              ..|.||.|:..:..|::
  Fly   748 PVVYNGFISISSWVLVFLV 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA7	NP_061985.2	rim_protein	1..2109	CDD:130324	199/994 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1048..1072		1/23 (4%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1185..1209		7/23 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2104..2146
osy	NP_001034071.1	CcmA	50..285	CDD:440746	75/277 (27%)
		YadH	578..773	CDD:440604	41/211 (19%)