Protein Alignment ABCA7 and CG42816

DIOPT Version :10

• Sequence 1: NP_061985.2
• Gene: ABCA7 / 10347
• HGNCID: 37
• Length: 2146
• Species: Homo sapiens
• Sequence 2: NP_730301.3
• Gene: CG42816 / 39977
• FlyBaseID: FBgn0261998
• Length: 1459
• Species: Drosophila melanogaster
• Alignment Length: 1667
• Identity: 428/1667 - (25%)
• Similarity: 728/1667 - (43%)
• Gaps: 351/1667 - (21%)

Human   535 PCYVDDVFLRVLSRSLPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSC 599
            |.:..|....:....:.:.:.:.:...|:|| |::|.|||.:|:.|:..||:...:.|:.|::..
  Fly    53 PIFKSDNSSTLQDVGIMIIVIIIFFVVVSLT-KSIVEEKELQLKVTLNLMGVGSCLQWVAWYIQT 116

Human   600 LGPFLLSAALLVLVLKLG------DILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAA 658
            ...||:.::::.|..||.      ..:|::|..:....|...:..|:..|||:|:..|.....:.
  Fly   117 FIIFLIGSSIITLFWKLVLPNSEISFMPFTHWSMALFVLLVLSHCTICFSFLMSSLISTTYRISL 181

Human   659 CGGLAYFSLYLPYVL-----CVAWRDRLPAGGRVAASL-----LSPVAFGFGCESLALLEEQGEG 713
            ...||..:.|||:::     |       ..|..|..||     |..:..|     :.:.|:.|||
  Fly   182 VTFLALIATYLPFLILHSKGC-------SEGLNVFLSLFLLSGLQVLVVG-----ICMWEDYGEG 234

Human   714 AQWHNV-GTRPTADVFSLAQVSGLLLLDAALYGLATWYLEAVCPGQYGIPEPWNFP--------- 768
            .||.|: .|.......|:..:..:::|.:.|..|...|||.:.||.||:|:||:||
  Fly   235 LQWGNLFETSWPGGTLSVGYILLVMILASFLSLLLCLYLEKIRPGPYGVPQPWHFPCTRCCSTES 299

Human   769 -------FRRSYWCGPRPPKSPAPCPTPLDPKVLVEEAPPGLSPGVSVRSLEKRFPGSPQPALRG 826
                   |.|.:......|....|      ...|:|..|.....||.:|.|.|.|  .....::.
  Fly   300 LLPYSRLFNRIFGIYSAAPDEERP------DLQLIEPDPVDKIAGVQIRGLSKTF--GKMEVVKN 356

Human   827 LSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILGHDVRSSMAAIRPHLGVCPQYNV 891
            :|.|.::|.||..:|||||||||.:|:|:|...|:.|:|.|.|.|:|......:..:|:|||.||
  Fly   357 VSFDMFEGQITVLMGHNGAGKTTLISMLAGFISPTSGTALINGFDIRQERRQAQRCIGLCPQQNV 421

Human   892 LFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVG 956
            ||..|:...|:..:.||:||..|.|..|....|:.:.|..|:.:..|:||||.||:||||.:..|
  Fly   422 LFKHLSSVSHIQLFSRLRGLRGAEVKSEVQNYLKKLNLQEKKRLAARNLSGGTQRRLSVACSLCG 486

Human   957 GSQVVILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGS 1021
            |.:|:|.|||:.|:||::||.:|.|:|:.:||.|::|:||.||:.|:|||||.:::.|:|.|.||
  Fly   487 GVKVLICDEPSTGLDPSARRELWRLILEAKEGCTILLTTHQLDDGEVLGDRVVIISDGQLRCIGS 551

Human  1022 PLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQHWV 1086
            ..||::.:.:...:| .:||      ::.|.:...|:.:|          .|||.|..:     :
  Fly   552 LPFLKKQVDASCLIT-CEAR------KRCDLEKLTSLISR----------HVGTIQPFS-----I 594

Human  1087 PGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTGYGISDTSLEEIFLKVVEECA 1151
            .|..:..:||.          :....|::|||:|::::..|.:.|:.:|..||||||:..
  Fly   595 KGRDVCYKLPL----------SKSKYFSSLFRDLESQMNILGVRGFSLSSVSLEEIFMSF----- 644

Human  1152 ADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETDQGSGPDAVGRVQGWAL 1216
               ..||                            |.:.:..|:....|.....|....||...:
  Fly   645 ---GAED----------------------------LNSRQSGGAEKRDDDDRDDDEENEVQDGNV 678

Human  1217 --TRQQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIVPPFGHYPALRLSPTMYGAQ 1279
              .::|.:|::.|:.:                ||:........|::.|..:|....:..|
  Fly   679 RSCKKQWRAMMTKKVM----------------ALYDNKVYFLLLLLTPIVYYITTLMMAT----- 722

Human  1280 VSFFSEDAPGDPGRARLLEALLQEAGLEEPPVQHSSHRFSAPEVPAEVAKVLASGNWTPESPSPA 1344
                   .|...||...   .:.:.|:::..:               :..|..|.::|.|..:.:
  Fly   723 -------KPHHSGRPTF---NISDYGVDKFTI---------------LLSVPVSKSYTEERRADS 762

Human  1345 CQCSRPGARRLLPDCPAAAGGPPPPQAVTGSGEVVQNLTGRNLSDFLVKTYPRLVRQGLKTKKWV 1409
            ......|..:|:                         :....:.|:        |....|:::..
  Fly   763 IASLIKGKLKLI-------------------------VVSEQIKDY--------VDDKWKSREGR 794

Human  1410 NEVRYGGFSLGGRDPGLPSGQELGRSVEELWALLSPLPGGALDRVLKNLTAWA---HSLDAQDSL 1471
            .|:.:...::   |.|                          ||.  .|..|.   |.:
  Fly   795 REINFVSMAI---DTG--------------------------DRT--GLIGWVGPRHYV------ 822

Human  1472 KIWFNNKGWHSMVAFVNRASNAILRAHLPPGPARHAHSITTLNHPLNLTKEQLSEGALMASSVDV 1536
                     |:....:|...||:.:..:.|     ..||...:.|..|.|:   |..|::::.|
  Fly   823 ---------HAAPMILNLVYNALAQELIGP-----KISIEVTSVPFTLRKK---EDFLISNNGD- 869

Human  1537 LVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLI 1601
             :.|.|:..:|.....|:..:|:|||:..|.||.:.||....|||.:..:||..:.:   :|:.:
  Fly   870 -IPIYVIGYVSIAMIIFSSAVIQERVSHMKMLQEVSGLEMITYWLSHLAFDMVVFFI---LVLAL 930

Human  1602 FLAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMAT 1666
            .|.....|       |..|||.:|:...:..|:: ..|..|:.|..::.::.|.|.: |.||:..
  Fly   931 LLPLYGYA-------PWYLLLCVLFFTGLAGLIF-IYFLISMLSATFLAVSMILLSV-IIGSLIL 986

Human  1667 FVLELFSDQKLQEVSRILKQVF----------LIFPHFCLGR-----GLIDMVRNQAMADAFERL 1716
            .:        |..::.|.|.|:          ||..:.|:.:     .|.....::|.....|.|
  Fly   987 MI--------LGALALIFKMVYVAIYVANMHPLIAGYNCIQKCFHYMSLCGSYISEAQNPLSENL 1043

Human  1717 -GDRQF--------------QSPLRWEVVGKNLLAMVIQGPLFLLFTLLL--------QHRSQ-L 1757
             .|..:              .:|:.|    .::|.|:  |...:||.|::        .:|.: .
  Fly  1044 TSDEMYCINPLAFLEPRCVCVNPMTW----PDMLVML--GTAIILFLLIMFFEYGSCVWYRCKGC 1102

Human  1758 LPQPRVRSLPLLGEEDEDVARERERVVQGATQGD-----VLVLRNLTKVYRGQRMPAVDRLCLGI 1817
            .|.....|:     ||..|:||.|::  .|...|     .||:..::|.| |....||:.:...:
  Fly  1103 CPYSSKGSI-----EDPKVSREAEKI--RAMDADQIGTRALVVNGVSKKY-GCDQLAVNNISFAL 1159

Human  1818 PPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELL 1882
            .|..|.||||.||||||:||:|:.|:....:|...::|:|:..:.:.|...:|||||||:.||.|
  Fly  1160 KPSHCVGLLGPNGAGKTTTFKMIVGEHSIDKGNIYISGYSMRMKRNKAMKELGYCPQSDSFFEFL 1224

Human  1883 TGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVV 1947
            |||:.|::...:.|.|...:.:.......:.|...:.|:....||||.|||:..|:| .|..:::
  Fly  1225 TGRQLLKVFLLIWGFPSKDLNKRCEKLADQFGFRKHLDKKITYYSGGTKRKINAAVA-CGANSLI 1288

Human  1948 FLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHL 2012
            .||||:.|:||::||.:|..:..|.::|::|:||||:|:|..||||:..|:|:|....:||.||:
  Fly  1289 CLDEPSAGVDPASRRHVWTIINEVAQQGKAVLLTSHNMDEINALCSKSVILVDGSIYAMGSVQHV 1353

Human  2013 KGRFAAGHTLTLRVPAARSQPAAAFVAAE------FPGAELREAH--GGRLRFQLPPGGRCALAR 2069
            |.:.|.|.||.|.|........|.....|      :|.|||:|.:  .|||.||:...  .:.:.
  Fly  1354 KNKIAKGMTLKLVVNVQPDNMVAMLTKIEDDIYMTYPNAELKEKYEFSGRLTFQISKD--TSWSE 1416

Human  2070 VFGELAVHGAEHGVEDFSVSQTMLEEVFLYFSKDQGKDEDTE 2111
            :|..:..:.:...:||:|:||..||:.|...::::.|.:..:
  Fly  1417 IFEYVEGNRSSWHLEDYSLSQPSLEDAFEEIAEERRKKKSNQ 1458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA7	NP_061985.2	rim_protein	1..2109	CDD:130324	428/1663 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1048..1072		3/23 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1185..1209		4/23 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2104..2146		1/8 (13%)
CG42816	NP_730301.3	rim_protein	<81..1451	CDD:130324	424/1630 (26%)