Protein Alignment ABCA7 and CG6052

DIOPT Version :10

• Sequence 1: NP_061985.2
• Gene: ABCA7 / 10347
• HGNCID: 37
• Length: 2146
• Species: Homo sapiens
• Sequence 2: NP_649002.3
• Gene: CG6052 / 39971
• FlyBaseID: FBgn0036747
• Length: 1725
• Species: Drosophila melanogaster
• Alignment Length: 1799
• Identity: 508/1799 - (28%)
• Similarity: 830/1799 - (46%)
• Gaps: 358/1799 - (19%)

Human   432 HRFWAGVVFLGPEDSSDPTEHPTPDLG-PGHVRIKIRMDIDVVTRTNKIRDRF--------WDPG 487
            |.|.|||.|   ||:.:..   |.|.| |.::...:|...::.|....|.|.:        :|..
  Fly   147 HNFLAGVQF---EDNENVN---TNDAGYPLNLNYSLRFPSELRTMQGPIIDTWRTSRLFLSYDTS 205

Human   488 PAADPLTD-----LRYVWGGFVYLQDLVERAAVRVLSGANPRA--GLYLQQMPYPCYVDDVFLRV 545
            .:.:.|.:     :.|:..||:.:|..:..:.:.:.||.....  .::||:.||..|..|..|..
  Fly   206 GSRNRLDNDGGVPVGYIREGFLPIQHALTMSWLALASGVTDTGIPAIHLQRFPYRAYTYDQLLSG 270

Human   546 LSRSLPLFLTLAWIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLS-----CLGPFLL 605
            |.:.||..:.|::||..:...|.|..|||.:|::.|:.:|:...:.|:.||:.     .|..||:
  Fly   271 LRQLLPFVILLSFIYPASTVTKYVTSEKELQLKEIMKLIGVHNWLHWVAWFVKSYIMLMLVVFLI 335

Human   606 SAALLVLVLKLGDILPYSHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLP 670
            .:.::|.......:|.:|....|.|||..:.|.:|...|:|:..||:|:.|:|...:.:|..|:|
  Fly   336 MSLIMVKFYASVAVLTFSSWVPVLLFLHTYVVTSVCLCFMLAVLFSKASTASAVAAIFWFLTYIP 400

Human   671 YVLCVAWRDRLPAGGRVAASLL-SPVAFGFGCESLALLEEQGEGAQWHNVGTRP--TADVFSLAQ 732
            |.....:.:||....::..||: |..|.|||...:.:.|..|||..|.|: ..|  |.|..:|..
  Fly   401 YSFGYYYYERLSLMSKLLISLIFSNSALGFGIHVIVMWEGTGEGITWRNM-FHPVSTDDSLTLFY 464

Human   733 VSGLLLLDAALYGLATWYLEAVCPGQYGIPEPWNFPFRRSYWCGPRPPKSPAPC-PTPLDPKVLV 796
            :...:...:.::.....|:|.|.||:||:|..|||...::||....|..:..|. .|.|......
  Fly   465 IIMTMSFGSIMFISICLYVEQVFPGEYGVPRRWNFMCHKNYWRQYVPSLNIVPSFQTILHGSAKA 529

Human   797 EEAPPGLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPS 861
            :........|:.:.:|:|.:  ....|::|:||..::..||..|||||||||||:::::|:..|:
  Fly   530 KSCRRAREVGIQLFNLQKNY--GKLKAVKGISLKMHRNEITVLLGHNGAGKTTTINMITGIVKPT 592

Human   862 GGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGL-SAAVVGPEQDRLLQ 925
            .|:|.:.|:|:|:.:|..|..||:|||.|:||..::|.:|:.|:.:|||: ....|..|..:.:.
  Fly   593 SGTAIVNGYDIRTHLAKARESLGICPQNNILFKEMSVRDHIIFFSKLKGIRGTKAVENEVGKYMT 657

Human   926 DVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRT 990
            .:.|..|..|..::|||||:||||:..|..|.::||:.|||::|:|.|.||.:|:||...::|||
  Fly   658 MLKLQDKSYVAAKNLSGGMKRKLSLCCALCGNAKVVLCDEPSSGIDAAGRRSLWDLLQSEKDGRT 722

Human   991 LILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDME 1055
            ::|:||::|||::||||:|:::.|:|.|.|:..:|::..|:||.|..:               |:
  Fly   723 ILLTTHYMDEADVLGDRIAILSEGKLQCQGTSFYLKKRFGTGYLLVCI---------------MQ 772

Human  1056 GSVDTRQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFREL 1120
            ...|             ||.  :..|::.:||..:....|..||...||  ..:...||.|.::|
  Fly   773 SGCD-------------VGA--VTQLIRKYVPPIKPERVLGTELTYRLP--TEYSKKFAELLQDL 820

Human  1121 DTRLAELRLTGYGISDTSLEEIFLKVVEECAADTD--MEDGSCGQHLCTGIAGLDVTLRLKMPPQ 1183
            |.:.|:|:|.|||:|..:||::|:      |.:||  ::.|:.|                  ||.
  Fly   821 DEKCAQLQLVGYGLSGATLEDVFM------AVNTDKRVQGGAEG------------------PPV 861

Human  1184 ETALENGEPAGSAPETDQGSGPDAVGRVQG----WALTRQQLQALLLKRFLLARRSRRGLFAQIV 1244
            :.:::..|....:...::       .|::.    |       |||.||:|....|:...|..|:|
  Fly   862 DGSIDFKELVFDSKTREK-------RRIRRCFMFW-------QALFLKKFYTTTRNYWLLGIQLV 912

Human  1245 LPALFVGLALVFSLIVPPFGHYPALRLSPTMYGAQVSFFSEDAPGDPGRARLLEALLQEAGLEEP 1309
            ||...:.|.::.|                  .|.::.:                        |.|
  Fly   913 LPIAVMALTILNS------------------RGGRIYY------------------------ELP 935

Human  1310 PVQHSSHRFSAPEVPAEVAKVLASGNWTPESPSPACQCSRPGARRLLPDCPAAAGGPPPPQAVTG 1374
            .:..|.:::|:       |.|:...|.|.::.|.|...|:.
  Fly   936 AMPISINQYSS-------AYVVLEDNTTDKTSSLADAYSKH------------------------ 969

Human  1375 SGEVVQNLTGRNLSDFLVKTYPR---LVRQG-LKTKKW-----VNEVRYGGFSLGGRDPGLPSGQ 1430
                             ::.|.|   |:|.| ||.:.:     ||..|...|
  Fly   970 -----------------LEHYARRCTLLRTGDLKFEDYILSHDVNHSRRIDF------------- 1004

Human  1431 ELGRSVEELWALLSPLPGGALDRVLKNLTAWAHSLDAQDSLKIWFNNKGWHSMVAFVNRASNAIL 1495
                                  ..|..||.      ::::..:|.|||..|:....:|...||:.
  Fly  1005 ----------------------HFLAGLTV------SENNFIVWLNNKPLHTAPLTLNLLHNALA 1041

Human  1496 RAHLPPGPARHAHSITTLNHPLNLTKE----QLSEGALMASSVDVLVSICVVFAMSFVPASFTLV 1556
            ...|    .:.|.:..| |.||..:.:    :|::|.::.:.:.:.:|:    .|.|:.|.:.:.
  Fly  1042 IKLL----GQDASTYVT-NEPLPYSDDTRTLRLNKGQVLGAEISINLSL----TMCFITAFYAIP 1097

Human  1557 LIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLIFLAFQQRAYVAPANLPALLL 1621
            :|.||.||||.||.:.|:....||..:.:||...:::.|...:|...||::..|:.|.:|.....
  Fly  1098 IIRERETRAKLLQFLSGVDVCAYWTSHIVWDYLVFVLSALSSILTIAAFKEIGYITPLDLSRYFY 1162

Human  1622 LLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMATFVLELFSDQKLQEVSRILKQ 1686
            :||::|:....|.|.||..||..:|.:..::.||..:| .|....|:...|...:|::|:..|..
  Fly  1163 MLLIFGFPGIMLSYAASGCFSDAATGFTRISIINTLMG-TGLFLMFMTLNFEAFQLKDVAEKLAW 1226

Human  1687 VFLIFPHFCLGRGLIDMVRNQAMADAFERLGDRQFQSPLR---------------WEVVG--KNL 1734
            .|.:.||:.|......:.....:.......|.|:....||               |...|  ..:
  Fly  1227 YFRLSPHYSLASSTHSIHIGYNIRRGCSIGGIRKLPKQLRCRNVPICCDIPGYYGWRKPGVLVEI 1291

Human  1735 LAMVIQGPLFLLFTLLLQHRSQLL------------PQPRVRSLPLLGEEDEDVARE---RERVV 1784
            ..|::.|.  .||.|::.|.:::.            .:.||.....: |.|..||.:   ||.:.
  Fly  1292 TYMIMLGS--TLFLLIVMHDAKVCNLIAEKLGNCFSKRKRVEGGTSI-ENDSVVAEQRVVREMIN 1353

Human  1785 QGATQGDVLVLRNLTKVYRGQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRG 1849
            .|.....:||.: ::|.||.:.  ||..:...:|..|||||||:|||||||||:|:.||...:.|
  Fly  1354 SGRKDVPLLVYK-ISKRYRSKL--AVKAISFHVPHAECFGLLGINGAGKTSTFKMLAGDEKITSG 1415

Human  1850 EAVLAG-----HSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSG 1909
            ||.:.|     |.|.|:       :|||||.||:||.|||||.|.:...||||....|.......
  Fly  1416 EAYIDGTNISTHKVYRK-------IGYCPQFDALFEDLTGRETLNIYCLLRGVQRRHVTPICWGL 1473

Human  1910 LARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVRE 1974
            ....|.:.:.|:....|||||:|||:||::::|:|:|::|||||:||||:|||.||..:..:...
  Fly  1474 AISFGFAKHMDKQTKHYSGGNRRKLSTAISVLGNPSVLYLDEPTSGMDPAARRQLWQIIGLIRTA 1538

Human  1975 GRSVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRV------------- 2026
            |:|::||||||:|||||||||||||:|.|:||||.|.||.:|:.|..|.::|
  Fly  1539 GKSIVLTSHSMDECEALCSRLAIMVDGEFKCLGSVQSLKNQFSKGLILKVKVKHKKKTFQRVVED 1603

Human  2027 ---------------------------PAARSQPAAAFVAAEFPGAELREAHGGRLRFQLPPGGR 2064
                                       .|.|......|::.|.|.|||:|.:.|.:.:.:|...
  Fly  1604 SSSSNDKKSISETDLKFLQMASVMESSQADRILKVNRFISKEIPDAELKEEYNGLITYYIPHSK- 1667

Human  2065 CALARVFGELAVHGAEHGVEDFSVSQTMLEEVFLYF-SKDQGKD 2107
             .|:::|..|..:..:..:||:.:.||.|||:||.| ||....|
  Fly  1668 -TLSKIFQLLETNSHKLNIEDYLIMQTRLEEIFLDFASKRDSSD 1710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA7	NP_061985.2	rim_protein	1..2109	CDD:130324	508/1799 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1048..1072		2/23 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1185..1209		1/23 (4%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2104..2146		1/4 (25%)
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324
		rim_protein	<149..1709	CDD:130324	506/1794 (28%)