Protein Alignment ABCA7 and CG1801

DIOPT Version :10

• Sequence 1: NP_061985.2
• Gene: ABCA7 / 10347
• HGNCID: 37
• Length: 2146
• Species: Homo sapiens
• Sequence 2: NP_728408.3
• Gene: CG1801 / 33104
• FlyBaseID: FBgn0031171
• Length: 1655
• Species: Drosophila melanogaster
• Alignment Length: 1913
• Identity: 402/1913 - (21%)
• Similarity: 676/1913 - (35%)
• Gaps: 549/1913 - (28%)

Human   403 VTECLSLDKLEAAPSEAALVSRALQLLAEHRFWAGVVFLGPEDSSDPTEHPTPDLGPGHVRIKIR 467
            |.:.|.|.......||:.:.::    ..|....||:||....|...|..          :.|.||
  Fly   103 VAKTLELSSTVGYESESEMQNQ----FDERTTLAGIVFNDLRDDGTPLT----------LSISIR 153

Human   468 MDIDVVTRTNKI-RDRFW--------DPG---PAADPLTDLRYVWGGFVYLQ------------- 507
            ...:..|....: .||.|        :||   ...|...|: |:..||:.||
  Fly   154 FPSEFRTIAPFLTEDRLWITRCSGRINPGRDRAKHDKQQDI-YIREGFLQLQHQIFVEWYHQLRK 217

Human   508 DLVERAAVRVLSGANPRAGLY---LQQMPYPCYVDDVFLRVLSRSLPLFLTLAWIYSVTLTVKAV 569
            |:|.       :...|...:|   |:....||.|..|      ..||.|| ..:||  .|....:
  Fly   218 DIVS-------TYPEPNVEVYNILLKAADEPCSVMSV------AQLPTFL-YNFIY--LLPFLNI 266

Human   570 VREKETRLRDTMR--------AMGLSRAVLWLGWFL-SCLGPFLLSAALLVLVLKLGDILPYSHP 625
            :|....::.|.:.        :.|:...:.:|..|| .|:...:.:..||......|....:|..
  Fly   267 IRNVAAQVEDGVMVHQWHYGYSFGMQWGIKFLVLFLRMCILGVIYTIMLLAFWGFGGREGEFSGT 331

Human   626 GVV--FLFLAAFAVATVTQSFLLSAFFSRAN-------------LAAACGGL-AYFSLYLPYVLC 674
            |.:  ..|:..:.|..:....:::..|:...             .||.|..| .|:.::..||..
  Fly   332 GTIAFVCFITLYTVEIIITGMVVAKLFANPTNAVLFALMLWLFMYAAFCIILERYWDIHKYYVFF 396

Human   675 VAWRDRLPAGGRVAASLLSPVAFGFGCE---SLALLEEQGEGAQWHNVGTRPTAD---VFSLAQV 733
            :.                  ||| ..|:   |::|.....|..:..|     |.|   :|:.|
  Fly   397 IL------------------VAF-CNCQMHFSMSLFRNCIEKPEMVN-----TIDFVLIFTSA-- 435

Human   734 SGLLLLDAALYGLATWYLEAVCPGQYGIPEPWNFPFRRSYWCGPRPPKSPAPCPTPLDPKVLVEE 798
                :..|.:|.|....::...||        .|..||.  ...||.|......|.:    .:..
  Fly   436 ----ISSALIYFLILLAIQWRMPG--------TFLSRRI--VNNRPRKQQESDTTIM----YLGR 482

Human   799 APP---------GLSPGVSVRSLEKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSIL 854
            ||.         |....:.:|.:......|.:..|:.:|:..|:|.:...|||.|:||.|.|.||
  Fly   483 APSFQNFEFGDVGSVELMRLRHVSTSHRDSERKILKNISMRIYRGEVFVILGHIGSGKLTLLRIL 547

Human   855 SGLFPPSGGSAFILGH------------DVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGR 907
            :||..|..|:.:|:|:            |.|.....:..||.|         ..|:|.||    |
  Fly   548 AGLKFPLRGNVYIMGNPFEPNGEARRLVDFRFDEHGLNKHLTV---------EQTIDYHV----R 599

Human   908 LKGLSAAVVGPEQDR----------LLQDVGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVI 962
            || ||.:    |.||          :|..  .|..:.|:...||.|..:.:::.....|.:.::|
  Fly   600 LK-LSPS----ESDRYEIERRKWLAILDQ--HVESRGVRIGKLSSGSMKLVALCCCLAGDTPIII 657

Human   963 LDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRR 1027
            |:|||..:.....:..|.::...:|.|..|::|:::.|||.:.||:.:::.|.|...|:|.|||.
  Fly   658 LEEPTTQLTGREAQIFWSIVHAEKENRAFIIATYNVGEAEHVADRIGILSMGVLEASGTPFFLRS 722

Human  1028 HLGSGYYLTLV-KARLPLTTNEKADTDMEGSVDTRQEKKNGSQGSRVGTPQLLALVQHWVPGARL 1091
            ...|...|.:: |..:|    ::..||.     ..|..:|....:.:|......|...:.|  ||
  Fly   723 KFSSSVDLVIIKKPHVP----DQPITDY-----INQFMQNIEPENEIGDSLTYRLPVIYRP--RL 776

Human  1092 VEELPHELVLVLPYTGAHDGSFATLFRELDTR---LAELRLTGYGISDTSLEEIFLKVVEECAAD 1153
            .:.|.|                    .|:|.:   :..:|:.|..:||     |::.:|
  Fly   777 QKLLIH--------------------LEIDRKMLGIENVRVVGAELSD-----IYMTLV------ 810

Human  1154 TDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENGEPAGSAPETDQGSGPDAVGRVQGWALTR 1218
                                .:.||:..             ..|:..|......|.:.|   ||:
  Fly   811 --------------------TSFRLQQQ-------------MIPDVTQTFKYQVVSQKQ---LTK 839

Human  1219 QQLQALLLKRFLLARRSRRGLFAQIVLPALFVGLALVFSLIVPPFGHYPALRLSPTMYGAQVSFF 1283
            |:::|:..|:.:..        |..|.|.:.:..:.|...|:        .|||..:
  Fly   840 QRMRAMFYKKMIHT--------APNVWPIIMIFTSFVLIAII--------ARLSVLL-------- 880

Human  1284 SEDAPGDPGRARLLEALLQEAGLEEPPVQHSSH-RFSAPEVPAEVAKVLASGNWTPESPSPACQC 1347
              |.|.:.                    |:|.| .|..||   :|.|.|.:
  Fly   881 --DMPKER--------------------QNSIHIGFREPE---DVVKYLPN-------------- 906

Human  1348 SRPGARRLLPDCPAAAGGPPPPQAVTGSGEVVQNLTGRNLSDFLVKTYPRLVRQGLKTKKWVNEV 1412
                    |.||                |.:.                   :|..:|    ||:.
  Fly   907 --------LKDC----------------GYID-------------------IRSAVK----VNKK 924

Human  1413 RYGGFSLGGRDPGLPSGQELG------RSVEELWALLSPLPGGALDRVLKNLTAWAHSLDAQDSL 1471
            :..|.|....|.....  |.|      |...||.:.      ||::.            |..:.|
  Fly   925 KSVGVSRTFDDDSFVC--EKGSYRNNLRKKNELRSF------GAVES------------DGDEHL 969

Human  1472 KIWFNNKGWHSMVAFVNRASNAILRAHLP------------PGPARHAHSITTLNHPLNLTKEQL 1524
            ..:.:...:||....:|...|.|||...|            |.|.:.:..|..|::.:......|
  Fly   970 NGYISQDMFHSAPMMLNLLQNVILRLSYPMQTDLVVLVENHPLPTQLSQKINVLDNKIAHIHVPL 1034

Human  1525 SEGALMASSVDVLVSICVVFAMSFVPASFTLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMC 1589
            ..|.::..:|.|                |.:.|:||.:...:.||.|.||...::|..|..||..
  Fly  1035 VVGCIIPLTVSV----------------FVIPLVEEEIYDVRFLQHMAGLGLKVFWGINLFWDWF 1083

Human  1590 NYLVPACIVVLIF-------LAFQQRAYVAPANLPALLLLLLLYGWSITPLMYPASFFFSVPSTA 1647
            .:.|.:.|:|:|.       ..|.:.|        .:::||..:|.:..||.|..|.|
  Fly  1084 TFFVYSVIIVVIMSLMGIGGFGFYENA--------IMVVLLTTFGLAALPLTYLVSMF------- 1133

Human  1648 YVVLTCINLFIGINGSMA-TFVLELFSDQKLQEVSRILKQVF---------LIFPHFCLGRG--L 1700
                        :|.|:. .|::.:.    ||.||.::..:.         :.|...|:..|  |
  Fly  1134 ------------VNKSIVRAFLVSVL----LQGVSGLVLYIIYWDVANSNTIFFYAACMSPGFSL 1182

Human  1701 IDMVRN---QAMADAF-----------------ERLGDRQFQSPLRWEVVG--KNLLAMVIQGPL 1743
            :|.|.|   |.:..|.                 |.:.:.:|.:..:|...|  ..:|.||:...:
  Fly  1183 LDGVSNVYAQNLEQAICIDKCEATDSCTEENMNEVVPNCKFDTFFKWAAPGILPPILYMVLSALI 1247

Human  1744 FLLFTLLLQ--------HRSQLLPQPRVRSLPLLGEEDEDVARERERVVQG----ATQGDVLVLR 1796
            ||:....::        |.|:.|.:.|..:.|.   :|.|||..::::.:.    |.|...||.:
  Fly  1248 FLMLIFWIELHRREKKFHTSRDLRKMRTATYPF---DDGDVADVKQKIAEADNTKAKQSVFLVDQ 1309

Human  1797 NLTKV-YRGQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAR 1860
            ...:| ..|:|:..|.   ..:......|:.|...:||:...|.:.|....:.||..:.|.....
  Fly  1310 VEARVPAAGKRIHTVS---FALNKYMSMGIFGPRNSGKSHLMRQLVGQRGFAFGEIYVRGLDFKY 1371

Human  1861 EPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAGT 1925
            :..:.|..|||.||...:...||.|||:.||..:||||||::.:........|.::.:..|....
  Fly  1372 DLESIHTYMGYSPQHRGLLNELTPREHIRLLCMIRGVPEAKIGEKMHDLCLMLNMTGWMHRKCSL 1436

Human  1926 YSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEA 1990
            .:...:.||..|||||....::.|||||.||..:.||.:||.|..:...|::::..::...||:.
  Fly  1437 LTAEKRHKLKIALALVAYNKILVLDEPTCGMPATTRREIWNILRYIRYCGKTIIFATNDELECKI 1501

Human  1991 LCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRV-----PAARSQP--------AAAFVAAEF 2042
            |...:.:..:.....:||.|:|:.:::.|..|.:|:     ..|.|:.        .|.||....
  Fly  1502 LADFIILFQDSEMLAIGSLQYLRYKYSHGFYLEVRLIRDGATLAESEENLRKDVENLAKFVNFLH 1566

Human  2043 PGAELREAHGGRL----RFQLPPGGRCALARVFGELAVHGAEHGVEDFSVSQTMLEEVFLYFSKD 2103
            ..:||    .|||    :|.:|. |....:.::|.:..:.....|.|:.:.|..:..|.....:.
  Fly  1567 NRSEL----VGRLNNWFKFYVPV-GHIVYSFLYGAMEKNKLRLNVSDYCIYQADMMSVVAQVQET 1626

Human  2104 QGKDEDTEEQKEAGVGVDPAPGLQHPKR 2131
            :.:.:....|.|..:.:|..    .||:
  Fly  1627 RAQLKHHLVQTEGPLPLDTT----SPKK 1650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA7	NP_061985.2	rim_protein	1..2109	CDD:130324	397/1889 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1048..1072		4/23 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1185..1209		2/23 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2104..2146		5/28 (18%)
CG1801	NP_728408.3	ABC2_membrane_3	<246..379	CDD:463674	24/141 (17%)
		rim_protein	<514..1537	CDD:130324	283/1303 (22%)