Protein Alignment ABCA7 and ldd

DIOPT Version :10

• Sequence 1: NP_061985.2
• Gene: ABCA7 / 10347
• HGNCID: 37
• Length: 2146
• Species: Homo sapiens
• Sequence 2: NP_001285513.1
• Gene: ldd / 318066
• FlyBaseID: FBgn0083956
• Length: 1998
• Species: Drosophila melanogaster
• Alignment Length: 2376
• Identity: 564/2376 - (23%)
• Similarity: 891/2376 - (37%)
• Gaps: 667/2376 - (28%)

Human    10 LLWKNFMYRRRQPVQLLVELLWPLFLFFILVAVRHSHPPLEHHECHFPNKPLPSAG-TVPWLQGL 73
            ||.|:.:.|.||....|:.|.||:.:|.:|..:|..:...|...|.:|.:.||:.. .||.....
  Fly    13 LLRKDLLVRWRQKGLSLILLAWPVMVFMLLYLIRLKYGSEELEACQYPTRLLPTKNQVVPAAFSY 77

Human    74 ICNVNNTCFPQLTPGEEPGRLSNFNDSLVSRLLADARTVLGGASAHRTLAGLGKLIATLRAARST 138
            ||::.|.|.| ..|.||   .|::.:       |...:|:...:|..|...|.|.:..| |.::
  Fly    78 ICSIENRCQP-AHPYEE---YSHWKE-------APLHSVIDVVNAFVTDERLHKAVVEL-AEKA- 129

Human   139 AQPQPTKQSPLEPPMLDVAELLTSLLRTESLGLALGQAQEPLHSLLEAAEDLAQELLALRSLVEL 203
                            :....:|:|:.::...:......| :.||:...|........::.|...
  Fly   130 ----------------NFVSAITTLITSDRFDIIRSNISE-IISLVPEIERRMNYSFDIKHLFSN 177

Human   204 RALLQRPRGTSGPLELLSEALCSVRGPSSTVGPSLNWYEASDLMELVGQEPESALP--------- 259
            |....:          |...||....|::...|.:|....|:...........|:|
  Fly   178 RETFVK----------LGVLLCGHPFPNTDTIPLVNEILESEDFSQANDAEIDAMPTRRRRRYED 232

Human   260 ---DSSLSPACSELIGALDSHPLSRLLWRRLKPLILGKLLFAPDTPFTRKLMAQVNRTFEELTLL 321
               |...:..|..|...:.|....:|.|..:||:|.|::|:.|....|..::...|.:||||..|
  Fly   233 LPTDWRPTKYCKRLYRDVTSTNQGKLTWNTIKPIIQGRILYTPANAMTESVVKFSNASFEELDRL 297

Human   322 RDV-----------------REVWEML-----GPRIFTFMNDSSNVAMLQRLLQMQDEGRRQPRP 364
            :.:                 :|.::.|     .|.:.:.:.|..::..::|:
  Fly   298 KQLSRAAATILTKLHTNATFQEAFDNLLKLAKSPLVKSLVGDDFDIGEIERV------------- 349

Human   365 GGRDHMEALRSFLDPGSGGYSWQDAHADVGHLVGTLGRVTECLSLDKLEAAPSEAALVSRALQLL 429
                 .|.:|:              :..:..::.|:..:.:|:|.|:.||..|...|..||.:|.
  Fly   350 -----FEYIRT--------------NQLIYDILTTVADLMDCVSADRFEAVESVEELHKRAYELN 395

Human   430 AEHRFWAGVVFLGPEDSSDPTEHPTPDLGPGHVRIKIRMDIDVVTRTNKIRDRFWDPGPAADPLT 494
            ....|.|.:              ...|:|......::.||.|....|.:.|:|||.||||...:.
  Fly   396 QNKLFLAAL--------------NLEDVGLKQASYRLHMDTDNTQPTFENRNRFWFPGPADSMVI 446

Human   495 DLRYVWGGFVYLQDLV------------------------------------------------- 510
            ||:| ..|||.|:.:|
  Fly   447 DLKY-HRGFVQLKQMVDLGIIKSKREEAGFAPEEDGPESGRSLSGLFSIKQVENDTPDEDDDDFD 510

Human   511 --------ERAAVRVLSGA---------------------------------------------- 521
                    |:||.:|.:.|
  Fly   511 LSLEESGDEKAAPKVSASASDHEATTISPSSLDGVTTEEVRVTTEQTVVSGDPDLLLLKNEDVLK 575

Human   522 -NPRAGL--------------------------YLQQMPYPCYVDDVFLR--VLSRSLPLFLTLA 557
             :.|.||                          |.:|.|||.:::|||.|  .|::.:.:...|.
  Fly   576 RSKRQGLFDLLGGFGGSGDANKKNKFEVDNMQFYTKQFPYPAFLNDVFKRGLYLAQGVQVAYLLG 640

Human   558 WIYSVTLTVKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVLKLGDILPY 622
            .:..|.|:|:..:..:|:|....||:|||......:.|.|.......:..||:..||..|.||.|
  Fly   641 LVVFVALSVRERIWMRESRNSMLMRSMGLKAHSELVAWALMSFLELCVIFALISGVLYSGGILGY 705

Human   623 SHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYVLCVAWRDRLPAGGRV 687
            ::...:..:..:|.:..::..::.:.||:.||:.|....|.:|....|:::.:.:..:|......
  Fly   706 TNWFFMMFYCLSFGLCLISFCYMCTNFFNSANIGAVASALLFFISLCPFIIVLMFDAKLSVFESF 770

Human   688 AASLLSPVAFGFGCESLALLEEQGEG-AQWHNVGTRPTADVFSLAQVSGLLLLDAALY---GLAT 748
            ...|....||..|...|..:|.|.|| ...|.:...|.....::|.:  :.|||..||   |||.
  Fly   771 LVDLSFTTAFAKGWGELIRMELQQEGLTVRHLIQVGPARSECAMALL--MFLLDLLLYAVIGLAY 833

Human   749 WYLEAVCPGQYGIPEPWNF-PFRRSYWCGPRPPKSPAPCPTPLDPKVLVEEAPPGLSPGVSVRSL 812
                    .:|...:.::| ...||                .||.|:           |.|:.::
  Fly   834 --------QRYKKTDNYSFVKVSRS----------------QLDGKL-----------GASLVNV 863

Human   813 EKRFPGSPQPALRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSGGSAFILG-HDVRSSM 876
            .|.: || :.|:..|||||.:..::..||.|||||:|.:.:|:|....|.|...:.| |.|
  Fly   864 SKLY-GS-KCAVSNLSLDFARNQVSCLLGRNGAGKSTLIKLLTGQIRQSSGKVLLAGEHQV---- 922

Human   877 AAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLK---GLSAAV--VGPEQDRLLQDVGLVSKQSVQ 936
                   |||.|.|:|...||..||:..|.::|   |.|..|  :..|..:.||.:.....:|..
  Fly   923 -------GVCWQDNILIPTLTAREHLQLYAQIKIPPGGSGGVEEIRSEVAQTLQSLNFGKHESYP 980

Human   937 TRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEA 1001
            :..||||.:|:|.|||||:....|||||||..|||..:|:.||:|:.:.|:||.:|.:||.:|||
  Fly   981 SWQLSGGYRRRLCVAIAFIASPSVVILDEPCNGVDAKARKDIWQLIERLRQGRAVIFATHFMDEA 1045

Human  1002 ELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEGSVDTRQEKKN 1066
            :.|.|.:.::..||:....|...|:|...|.|.:.|..|            |..|.....|:.:
  Fly  1046 KYLSDSLVIMRNGRIIAQHSRDSLQRLCTSNYSIRLRCA------------DATGVTFVIQKAQ- 1097

Human  1067 GSQGSRVGTPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELDTRLAELRLTG 1131
                      |||...|....||   .:.||.|.:...| ..|....|..|.|    |.:.::|.
  Fly  1098 ----------QLLPQTQVTHSGA---ADYPHSLTINASY-AEHLTPGAVEFLE----LLQSQVTA 1144

Human  1132 YGISD------TSLEEIFLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETALENG 1190
            ..|||      :|||:.|                                        |....||
  Fly  1145 GSISDVELTTSSSLEQEF----------------------------------------EQLNRNG 1169

Human  1191 EPAG-SAPETDQGSGPDAVGRVQGWALTR-------QQLQALLLKRFLLARRSRRGLFAQIVLPA 1247
            |.|| ..|.:|:.      |.|.|.|:..       :|.:.|:.||.....|:.|.|...::|||
  Fly  1170 EDAGPRRPASDRS------GVVAGPAMITDEPPTACKQFRLLMGKRLRHLSRNYRLLLYVLLLPA 1228

Human  1248 LFVGLALVFSLIVPPFGHYPALRLSPTMYGAQVSFFSEDAPGDPGRARLLEALLQEAGLEEPPVQ 1312
            ||...|:.|                       ||:..||
  Fly  1229 LFELCAMWF-----------------------VSYRLED-------------------------- 1244

Human  1313 HSSHRFSAPEVPAEVAKVLASGNWTPESPSPACQCSRPGARRLLPDCPAAAGGPPPPQAVTGSGE 1377
                         :...||                  |.:|.|.|                   :
  Fly  1245 -------------DFDTVL------------------PLSRSLYP-------------------Q 1259

Human  1378 VVQNLTGRNLSDFLVKTYP------------RLVRQGLKTKKWV-------NEVRYGGFSLGGRD 1423
            ..|.|:....:.|..|.||            |:.....::..||       :|.||||:.|.|
  Fly  1260 TAQFLSHERATSFSEKLYPQLRTSCDHLGECRVFNTSQQSYDWVLNSWGEYSERRYGGYGLNG-- 1322

Human  1424 PGLPSGQELGRSVEELWALLSPLPGGALDRVLKNLTAWAHSLDAQDSLKIWFNNKGWHSMVAFVN 1488
                                    .||                     .:|:||||:|||:|::|
  Fly  1323 ------------------------SGA---------------------TVWYNNKGYHSMMAWLN 1342

Human  1489 RASNAILRAHLPPGPARHAHSITTLNHPLNLTKEQLSEGALMASSVDVLVSICVVFAMSFVPASF 1553
            ..::.:||..:....:    ||.|||.|..|...:||..:::..:.|..:...::.|...|.||.
  Fly  1343 DLNSELLRTTMNDSES----SILTLNEPWKLGFAELSTSSILRQAGDGSMVFILLIAFGLVVASG 1403

Human  1554 TLVLIEERVTRAKHLQLMGGLSPTLYWLGNFLWDMCNYLVP-----ACIVVLIFLAFQQRAYVAP 1613
            ::.|:.|||...|..|.:.|:|...|||...:||   |||.     .|:||:  |.|....:|..
  Fly  1404 SVYLVNERVNGEKLQQRLCGVSAVTYWLVALVWD---YLVMVLGLIVCLVVI--LMFGMPVFVDR 1463

Human  1614 ANLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINGSMATFVLELFSDQKLQ 1678
            ..|..::.|.|.:.::..|.::.|...||..|.|.|.:.|.||.:.:.......:|.:..|....
  Fly  1464 QQLVGIIGLSLAFSFACVPSVHVAEKIFSDSSIAIVSIFCANLIVPLVTMGIILILGVVGDGPAW 1528

Human  1679 EVSR-ILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDRQFQSPLRWEVVGKNLLAMVIQGP 1742
            :..| .|.|.|||||...||.|.:::.:|..:|..|.|.....::.||..:::|::..|:::.|.
  Fly  1529 DDWRHALNQAFLIFPIHALGDGFLELCKNYMVALVFRRYDIDSYKHPLASDLLGRHFTALLLVGV 1593

Human  1743 LFLLFTLLLQ-HRSQLLPQPRVRSLPLLGEEDEDVARERERVVQ------------GATQGDVLV 1794
            ..|:..:|:: |..:.|.|...|.|      |....||.:::.|            ....|:.:.
  Fly  1594 AALIINVLIEWHLLRRLWQRVERLL------DCTYRRELDKLGQLKLVNIQSIFKSCVDTGEAVR 1652

Human  1795 LRNLTKVYRGQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVA 1859
            ..||...||.... ||..:...:..||||||||.|||||::.|:::||......|:...
  Fly  1653 AENLWLAYRRGHY-AVRNVNFSVQRGECFGLLGKNGAGKSTIFKLLTGQLQPDVGQIYF------ 1710

Human  1860 REPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAG 1924
            .:|     .:.|||||:.:..|||..|.:....||||:.:               |..:.||...
  Fly  1711 EQP-----GISYCPQSNPLDPLLTTTECIRFYGRLRGIRD---------------LDQFLDRVLD 1755

Human  1925 TY-------------SGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGR 1976
            ||             ||||:|||..|:...|....|.:||||:.|||..|..::.::..::...|
  Fly  1756 TYELRPYKDVQVRNLSGGNRRKLTVAVTCCGCTPTVLMDEPTSDMDPVTRDMVYATIEQLLLARR 1820

Human  1977 SVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARSQPAAAFVAAE 2041
            :|:|||||:.|.|.||.|:|::..|:.....|||.||......:.:|.....|:....:..:...
  Fly  1821 AVVLTSHSVSEIEHLCQRVAVLRAGQVIASDSPQRLKSEHGGYYAVTCFCGPAQQAILSRSLNQR 1885

Human  2042 FPGAELREAHGGRLRFQL---PPGG---RCALARVFG---ELAVHGAEHGVEDFSVSQTMLEEVF 2097
            .|||...:.:...|||.:   .||.   ...|:.:|.   ::.|:     |..||:|:...|.||
  Fly  1886 LPGARDLQHYAHSLRFLVRVRSPGSLGDAPLLSELFAILCDVCVN-----VARFSLSRCRFETVF 1945

Human  2098 ---LYFSKDQG-----KDEDTEEQKEAGVGVDPAPG 2125
               |..|:..|     ||:..:..|.......||.|
  Fly  1946 ERILDSSESNGSNGVHKDQQQQVAKNDLPSKSPAVG 1981

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCA7	NP_061985.2	rim_protein	1..2109	CDD:130324	560/2358 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1048..1072		3/23 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1185..1209		7/24 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2104..2146		7/27 (26%)
ldd	NP_001285513.1	rim_protein	179..1867	CDD:130324	490/2059 (24%)