DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TLR6 and Tollo

DIOPT Version :9

Sequence 1:NP_001381482.1 Gene:TLR6 / 10333 HGNCID:16711 Length:796 Species:Homo sapiens
Sequence 2:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster


Alignment Length:858 Identity:200/858 - (23%)
Similarity:357/858 - (41%) Gaps:194/858 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    32 NEFAVDKSKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVF 96
            |:..:......|.||..   |||  ||:.:|.|::::.:.::.|..|..||::.|.:..:...||
  Fly   436 NDNKLQAVPEALAHVQL---LKT--LDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRGVF 495

Human    97 KFNQDLEYLDLSHNQLQKISCHPI---VSFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSAMKL 158
            .....|:.|:||.|:|:.|....:   ...:.:.|..|..|:  |...|..|..|.:|.:|..:|
  Fly   496 DRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKS--IAGLFTELPNLVWLNISGNRL 558

Human   159 QKLDLLPIAHLHLSYILLDLR--------NYYIKENETESLQILNAKTLHLVFHPTSLFAIQVNI 215
            :|.|   .:|:.:....||:|        ||:..|:|. ||...:| :.:|:   |.:.|..:..
  Fly   559 EKFD---YSHIPIGLQWLDVRANRITQLGNYFEIESEL-SLSTFDA-SYNLL---TEITASSIPN 615

Human   216 SVNTLGCLQLTNIKLNDDNCQ-----VFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQFLWP 275
            ||..|        .|||:...     .|.| ...|||    ::...|.:.|.....:|:......
  Fly   616 SVEVL--------YLNDNQISKIQPYTFFK-KPNLTR----VDLVRNRLTTLEPNALRLSPIAED 667

Human   276 K--PVEYL--NIY----NLTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTVFSEMN 332
            :  |..|:  |.|    ||..::.:..|    |:|..:.:.::.|        ...|.......:
  Fly   668 REIPEFYIGHNAYECDCNLDWLQKVNRE----SRTQPQLMDLDQI--------HCRLAYARGSSH 720

Human   333 IMMLTISDTPFI---------------------HMLCPHAPSTFKFLNFTQNVFTDSIFEKCSTL 376
            :.::......|:                     .|.||...|.:...::|.||...|......||
  Fly   721 VSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTL 785

Human   377 ---VKLET--LILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLS 436
               :.:::  |.|..|..::|.....:.:  ..|::|.::.:.:|                    
  Fly   786 PSHIPMDSTQLYLDGNNFRELQSHAFIGR--KRLKVLHLNHSRIE-------------------- 828

Human   437 SNMLTDSVFRCLPPRIKVLDLHSNKIKSV-PKQVVKLEALQELNVAFNSLTDLPGCGSFS---SL 497
              :|.:..|..| ..::||.|.||::|:: ..:...|:.||||.:..|::..:... :|:   .|
  Fly   829 --VLHNRTFYGL-LELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIATIDTL-TFTHLYHL 889

Human   498 SVLIIDHNSV-SHPSADFFQSCQKMRSIKAGDNPFQCTCE----LREFVKNIDQV------SSEV 551
            .:|.:|||:: |....:|..|  .:..::...||:.|:||    ||:::...:.|      ..:|
  Fly   890 KILRLDHNAITSFAVWNFLPS--YLNELRLASNPWTCSCEFIDKLRDYINRHEYVVDKLKMKCDV 952

Human   552 LEG--------WPDS--------YKC------------DYPESYRGSPLKDFHMSELSCN----- 583
            :.|        :|.|        .:|            :|.|...|....:...:::..|     
  Fly   953 ISGNSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDNNFNYAEQAGGENASNATSTKMILNQPPKL 1017

Human   584 --ITLLIVTIGATMLVLAVTVTSLCIYLDLPWYLRMVCQ-WTQTRRRAR-----NIPLEELQRNL 640
              |.:|:..:.|.:.|:      :||  .|.:..|...: |..:|...|     ...:::.:|..
  Fly  1018 DYIPILVAILTAFIFVM------ICI--SLVFIFRQEMRVWCHSRFGVRLFYNAQKDVDKNEREK 1074

Human   641 QFHAFISYSEHDSAWVKSELVPYLE--KEDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLS 703
            .|.||:|||..|..:|..||.|.||  :...::|||:|:|..|..:.|.|:..|:.|.::|.|:|
  Fly  1075 LFDAFVSYSSKDELFVNEELAPMLEMGEHRYKLCLHQRDFPVGGYLPETIVQAIDSSRRTIMVVS 1139

Human   704 PNFVQSEWCHYELYFAHHNLFHEGSNNLILILLEPIPQNSI-PNKYHKLKALMTQRTYLQWPKEK 767
            .||::||||.:|...||.::..:....||:|:|..:||..: |:    |:..:...|||||..: 
  Fly  1140 ENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVPQKELDPD----LRLYLKTNTYLQWGDK- 1199

Human   768 SKRGLFWANIRAA 780
                |||..:|.|
  Fly  1200 ----LFWQKLRFA 1208

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TLR6NP_001381482.1 LRR 1 54..77 6/22 (27%)
LRR 2 78..101 6/22 (27%)
LRR 3 102..122 7/22 (32%)
LRR 4 123..147 6/23 (26%)
LRR 5 148..168 6/19 (32%)
LRR 6 169..196 9/34 (26%)
LRR 7 197..219 5/21 (24%)
LRR 8 220..250 9/34 (26%)
LRR 9 251..277 3/27 (11%)
LRR 10 278..303 7/30 (23%)
LRR 11 304..330 2/25 (8%)
LRR 12 331..354 4/43 (9%)
LRR 13 355..378 6/25 (24%)
LRR 14 379..404 4/26 (15%)
LRR 15 405..429 3/23 (13%)
LRR 16 430..450 3/19 (16%)
LRR 17 451..474 7/23 (30%)
LRR 18 475..496 6/23 (26%)
LRR 19 497..520 8/23 (35%)
TolloNP_524757.1 LRR_RI <85..281 CDD:238064
leucine-rich repeat 100..123 CDD:275380
leucine-rich repeat 124..144 CDD:275380
LRR_8 152..222 CDD:290566
leucine-rich repeat 154..177 CDD:275380
leucine-rich repeat 178..201 CDD:275380
LRR 210..656 CDD:227223 64/247 (26%)
leucine-rich repeat 212..235 CDD:275380
leucine-rich repeat 236..259 CDD:275380
leucine-rich repeat 260..283 CDD:275380
LRR_RI 276..558 CDD:238064 34/128 (27%)
leucine-rich repeat 284..307 CDD:275380
leucine-rich repeat 308..333 CDD:275380
leucine-rich repeat 334..357 CDD:275380
leucine-rich repeat 358..381 CDD:275380
leucine-rich repeat 382..405 CDD:275380
leucine-rich repeat 406..429 CDD:275380
leucine-rich repeat 430..452 CDD:275380 4/15 (27%)
leucine-rich repeat 453..500 CDD:275380 14/48 (29%)
leucine-rich repeat 501..521 CDD:275380 7/19 (37%)
leucine-rich repeat 525..547 CDD:275380 6/23 (26%)
leucine-rich repeat 548..573 CDD:275380 7/27 (26%)
leucine-rich repeat 604..640 CDD:275380 11/47 (23%)
leucine-rich repeat 641..688 CDD:275380 12/50 (24%)
leucine-rich repeat 689..816 CDD:275380 20/140 (14%)
LRR_8 815..875 CDD:290566 18/82 (22%)
leucine-rich repeat 817..864 CDD:275380 13/69 (19%)
LRR_8 864..921 CDD:290566 14/59 (24%)
leucine-rich repeat 865..888 CDD:275380 6/23 (26%)
leucine-rich repeat 889..910 CDD:275380 7/20 (35%)
TIR 1076..1211 CDD:214587 53/142 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X221
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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