DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TLR6 and Tl

DIOPT Version :9

Sequence 1:	NP_001381482.1	Gene:	TLR6 / 10333	HGNCID:	16711	Length:	796	Species:	Homo sapiens
Sequence 2:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster

Alignment Length:	913	Identity:	214/913 - (23%)
Similarity:	352/913 - (38%)	Gaps:	253/913 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    41 RGLIHVPKD----------LPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSV 95
            |.|.|:|.:          |.|:..:.:|..:...:|:        .|..:....|:::.:...:
  Fly   160 RRLTHIPANLLTDMRNLSHLELRANIEEMPSHLFDDLE--------NLESIEFGSNKLRQMPRGI 216

Human    96 FKFNQDLEYLDLSHNQLQKISCH---------------------PIVSFRHL------DLSFNDF 133
            |.....|:.|:|..|||..::.|                     |...|.||      :||.|.|
  Fly   217 FGKMPKLKQLNLWSNQLHNLTKHDFEGATSVLGIDIHDNGIEQLPHDVFAHLTNVTDINLSANLF 281

Human   134 KALP-------------------------ICKEFGNLSQLNFLGLSAMKLQKL--DLL----PIA 167
            ::||                         ..:.|.|..:|..|.|.| :||.|  ||.    .|.
  Fly   282 RSLPQGLFDHNKHLNEVRLMNNRVPLATLPSRLFANQPELQILRLRA-ELQSLPGDLFEHSTQIT 345

Human   168 HLHLSYILLDLRNYYIKENETE--SLQILNAKTLHLVFHPTSLFAIQVNI--------------- 215
            ::.|...||......:.|::..  ||.:.|.:..||   |.||||...|:
  Fly   346 NISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHL---PDSLFAHTTNLTDLRLEDNLLTGISG 407

Human   216 ----SVNTLGCLQLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQFLWPK 276
                ::..|..|.::..:|...:.:.|:.     |.|...|:...|.|:.....|..:.|.....
  Fly   408 DIFSNLGNLVTLVMSRNRLRTIDSRAFVS-----TNGLRHLHLDHNDIDLQQPLLDIMLQTQINS 467

Human   277 PVEY------LNIYNLTII----------ESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALY 325
            |..|      ||:.|.:||          ..:||.|.:|:  .:.:|..|.:   .|| ||..|:
  Fly   468 PFGYMHGLLTLNLRNNSIIFVYNDWKNTMLQLRELDLSYN--NISSLGYEDL---AFL-SQNRLH 526

Human   326 TVFS-------------------EMNIMMLTISDTPFIHMLCPHAPSTFKFLNFTQNVFTDSIFE 371
            ...:                   ..|::.:.::|.|   ::|.  .:...|:...:.|..    .
  Fly   527 VNMTHNKIRRIALPEDVHLGEGYNNNLVHVDLNDNP---LVCD--CTILWFIQLVRGVHK----P 582

Human   372 KCSTLVKLET---LILQKNGLKDLFKVGLMTKDM-PSLEI--LDVSWNSLESGRHKE-----NC- 424
            :.|...||.|   :..|.|.|:     |...:.: |...|  ||.|    :..|.::     ||
  Fly   583 QYSRQFKLRTDRLVCSQPNVLE-----GTPVRQIEPQTLICPLDFS----DDPRERKCPRGCNCH 638

Human   425 --TWVESIVVLNLSSNMLTDSVFRCLPPRI-------KVLDLH--SNKIKSVPK-QVVKLEALQE 477
              |: :..:|:|..|..||.      .||:       ::::||  :|.:..:|. .....|::..
  Fly   639 VRTY-DKALVINCHSGNLTH------VPRLPNLHKNMQLMELHLENNTLLRLPSANTPGYESVTS 696

Human   478 LNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSA---DFFQSCQKMRSIKAGDNPFQCTCELRE 539
            |::|.|:||.:......::|:.|.|..|.:...:|   .|.....|.||:|...||:.|.|..:.
  Fly   697 LHLAGNNLTSIDVDQLPTNLTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLSGNPWMCDCTAKP 761

Human   540 FV----KNIDQVSSEVLEGWPDSYKCDYPESYRGSPLKDFHMSELSCN---------ITLLIVTI 591
            .:    .|.:::      |..:...|...|    .|.:   |.|||.|         ...|.|.|
  Fly   762 LLLFTQDNFERI------GDRNEMMCVNAE----MPTR---MVELSTNDICPAEKGVFIALAVVI 813

Human   592 GATMLVLAVTV-------TSLCIYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYS 649
            ..|.|:...|.       |.:.|:|    |...:..|..|.        |:|.::.:|.||||||
  Fly   814 ALTGLLAGFTAALYYKFQTEIKIWL----YAHNLLLWFVTE--------EDLDKDKKFDAFISYS 866

Human   650 EHDSAWVKSELVPYLE--KEDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWC 712
            ..|.::::..|||.||  .:..|:|:|||:::.|..|.|||:..:..|.::|.|||.||::|||.
  Fly   867 HKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQNFIKSEWA 931

Human   713 HYELYFAHHNLFHEGSNNLILILLEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLFWANI 777
            ..|...||.:..:||.:.:|:|:...|  ..:.....:|||.:...|||:|...     .||..:
  Fly   932 RLEFRAAHRSALNEGRSRIIVIIYSDI--GDVEKLDEELKAYLKMNTYLKWGDP-----WFWDKL 989

Human   778 RAA 780
            |.|
  Fly   990 RFA 992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TLR6	NP_001381482.1	LRR 1	54..77		2/22 (9%)
		LRR 2	78..101		3/22 (14%)
		LRR 3	102..122		8/40 (20%)
		LRR 4	123..147		11/54 (20%)
		LRR 5	148..168		10/25 (40%)
		LRR 6	169..196		6/28 (21%)
		LRR 7	197..219		8/40 (20%)
		LRR 8	220..250		6/29 (21%)
		LRR 9	251..277		5/25 (20%)
		LRR 10	278..303		10/40 (25%)
		LRR 11	304..330		7/44 (16%)
		LRR 12	331..354		4/22 (18%)
		LRR 13	355..378		3/22 (14%)
		LRR 14	379..404		6/28 (21%)
		LRR 15	405..429		8/33 (24%)
		LRR 16	430..450		5/19 (26%)
		LRR 17	451..474		5/32 (16%)
		LRR 18	475..496		5/20 (25%)
		LRR 19	497..520		6/25 (24%)
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	11/66 (17%)
		leucine-rich repeat	176..198	CDD:275380	4/29 (14%)
		leucine-rich repeat	199..222	CDD:275380	3/22 (14%)
		LRR_RI	216..542	CDD:238064	74/340 (22%)
		LRR_8	221..281	CDD:290566	14/59 (24%)
		leucine-rich repeat	223..270	CDD:275380	11/46 (24%)
		leucine-rich repeat	271..294	CDD:275380	6/22 (27%)
		leucine-rich repeat	295..320	CDD:275380	2/24 (8%)
		leucine-rich repeat	321..343	CDD:275380	9/22 (41%)
		LRR_8	342..402	CDD:290566	16/62 (26%)
		leucine-rich repeat	344..367	CDD:275380	5/22 (23%)
		leucine-rich repeat	368..391	CDD:275380	10/25 (40%)
		LRR_8	390..450	CDD:290566	9/64 (14%)
		leucine-rich repeat	392..415	CDD:275380	0/22 (0%)
		leucine-rich repeat	416..439	CDD:275380	5/27 (19%)
		leucine-rich repeat	440..474	CDD:275380	7/33 (21%)
		leucine-rich repeat	475..498	CDD:275380	5/22 (23%)
		LRR_8	477..534	CDD:290566	16/62 (26%)
		leucine-rich repeat	499..520	CDD:275380	6/25 (24%)
		leucine-rich repeat	523..552	CDD:275380	1/28 (4%)
		LRRCT	561..619	CDD:214507	14/71 (20%)
		LRRNT	631..667	CDD:214470	10/42 (24%)
		leucine-rich repeat	664..693	CDD:275380	4/28 (14%)
		LRR_8	669..726	CDD:290566	14/56 (25%)
		leucine-rich repeat	694..715	CDD:275380	5/20 (25%)
		leucine-rich repeat	716..737	CDD:275380	5/20 (25%)
		LRRCT	751..800	CDD:214507	14/61 (23%)
		TIR	858..996	CDD:214587	52/142 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920