DRSC/TRiP Functional Genomics Resources

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Protein Alignment TLR6 and 18w

DIOPT Version :10

Sequence 1:NP_006059.2 Gene:TLR6 / 10333 HGNCID:16711 Length:796 Species:Homo sapiens
Sequence 2:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0287775 Length:1385 Species:Drosophila melanogaster


Alignment Length:864 Identity:207/864 - (23%)
Similarity:331/864 - (38%) Gaps:213/864 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    29 SDGNEFAVDKSKRGLIHVP---KDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQL 90
            ||..|  :|.|...|..||   :||.: .|.||:.:|.|:|.:.:....|::||.|||..|||..
  Fly   429 SDLKE--LDLSSNQLTEVPEAVQDLSM-LKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGN 490

Human    91 LDLSVFKFNQDLEYLDLSHNQLQKI-----SCHPIVSFRHLDLSF-NDFKALPICKEFGNLSQLN 149
            :.:.:|:....|..|:|:.|::|.|     ..:..:....||.:| .|...:     |..|:.|.
  Fly   491 ITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGI-----FATLASLL 550

Human   150 FLGLSAMKLQKLDL------LPIAHLHLSYILLDLRNYYIKENETESLQILNAKTLHLVFHPTSL 208
            :|.||...|...|.      |....:|.:||.. |.||| |..|...:..|:|....:    |.:
  Fly   551 WLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEA-LGNYY-KLQEEIRVTTLDASHNRI----TEI 609

Human   209 FAIQVNISVNTLGCLQLTNIKLNDDNCQVFIKFLSELTR----GSTLLNFTLNHIETTWKCLVRV 269
            .|:.|   .|::..|.:.|..:.......|:. .:.|.|    .:.|...:||        .:||
  Fly   610 GAMSV---PNSIELLFINNNIIGQIQANTFVD-KTRLARVDLYANVLSKISLN--------ALRV 662

Human   270 FQFLWPKPV----------------EYL-NIYNLTIIESIREEDFTYSKTTLKALTIEHITNQVF 317
            ......|||                |:| .|.|||    .|:.........::.| :.|      
  Fly   663 APVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLT----TRQHPHVVDLGNIECL-MPH------ 716

Human   318 LFSQTALYTVFSEMNIMMLTISD---------TPFIH----------MLCPHAPSTFKFLNFTQN 363
              |::|.....:.     |:.||         .|..|          ::||...|.|....:..|
  Fly   717 --SRSAPLRPLAS-----LSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWATN 774

Human   364 VFTDSIFEKC--STLVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRHKENCTW 426
            :.      .|  ..|..|...|.|  .:.||:..|   .:||.||:..:      :||......:
  Fly   775 IV------DCGRQDLAALPNRIPQ--DVSDLYLDG---NNMPELEVGHL------TGRRNLRALY 822

Human   427 VESIVVLNLSSNMLTDSVFRCLPPRIKVLDLHSNKIKSVP-KQVVKLEALQELNVAFNSLTDLPG 490
            :.:..::.|.:..|...|      .::||.|.:||:.::. .:...|..|:||.:..|.||.:..
  Fly   823 LNASNLMTLQNGSLAQLV------NLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISN 881

Human   491 CGSFS---SLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTC----ELREFVKNIDQVS 548
             .:|.   ||.||.:|:|.:|  |....|....::.:..|.|.:.|.|    ||.:||.:    :
  Fly   882 -ATFEPLVSLEVLRLDNNRLS--SLPHLQYRHSLQGLTLGRNAWSCRCQQLRELAQFVSD----N 939

Human   549 SEVLEGWPDSYKCDY---------------PESYRGSPLKDFHMSELSCN--------ITLLIVT 590
            :.|:....|.|..|.               |:.   |.|.|...|.:|.:        :.||   
  Fly   940 AMVVRDAHDIYCLDAGIKRELELIGNLANGPDC---SDLLDASASNISSSQDLAGGYRLPLL--- 998

Human   591 IGATMLVLAVTVTSLCIYLDLPWYLRM---------VCQWTQTRRRARNIPLEELQRNLQFHAFI 646
              |.:|||...|..|.|.......:||         ||:           |..|....| :.|.|
  Fly   999 --AAVLVLIFLVVVLIIVFVFRESVRMWLFAHYGVRVCE-----------PRFEDAGKL-YDAII 1049

Human   647 SYSEHDSAWVKSELVPYLE--KEDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQS 709
            .:||.|..:|...:...||  :...::|:.:|:..|..|.:: ::.....|.|.|.||:.|.:.:
  Fly  1050 LHSEKDYEFVCRNIAAELEHGRPPFRLCIQQRDLPPQASHLQ-LVEGARASRKIILVLTRNLLAT 1113

Human   710 EWCHYELYFAHHNLFHEGSNNLI--LILLEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGL 772
            ||...|.    .|.|||....|.  |:::|   :.|:..:...:..|   ..||:  ...|.|.|
  Fly  1114 EWNRIEF----RNAFHESLRGLAQKLVIIE---ETSVSAEAEDVAEL---SPYLK--SVPSNRLL 1166

Human   773 -----FWANIRAAFNMKLT 786
                 ||..:|.|..::|:
  Fly  1167 TCDRYFWEKLRYAIPIELS 1185

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
TLR6NP_006059.2 leucine-rich repeat 36..53 CDD:275380 7/19 (37%)
leucine-rich repeat 54..77 CDD:275378 7/22 (32%)
LRR 1 54..77 7/22 (32%)
LRR <55..327 CDD:443914 74/304 (24%)
leucine-rich repeat 78..101 CDD:275378 9/22 (41%)
LRR 2 78..101 9/22 (41%)
leucine-rich repeat 102..122 CDD:275378 6/24 (25%)
LRR 3 102..122 6/24 (25%)
leucine-rich repeat 123..147 CDD:275378 6/24 (25%)
LRR 4 123..147 6/24 (25%)
LRR 5 148..168 7/25 (28%)
leucine-rich repeat 148..161 CDD:275378 5/12 (42%)
LRR 6 169..196 10/26 (38%)
leucine-rich repeat 174..196 CDD:275380 8/21 (38%)
LRR 7 197..219 3/21 (14%)
LRR 8 220..250 5/33 (15%)
LRR 249..>531 CDD:443914 70/323 (22%)
LRR 9 251..277 5/25 (20%)
LRR 10 278..303 8/41 (20%)
LRR 11 304..330 4/25 (16%)
LRR 12 331..354 7/41 (17%)
LRR 13 355..378 4/24 (17%)
leucine-rich repeat 379..404 CDD:275380 7/24 (29%)
LRR 14 379..404 7/24 (29%)
leucine-rich repeat 405..429 CDD:275380 4/23 (17%)
LRR 15 405..429 4/23 (17%)
leucine-rich repeat 430..451 CDD:275380 3/20 (15%)
LRR 16 430..450 3/19 (16%)
LRR 17 451..474 6/23 (26%)
leucine-rich repeat 452..474 CDD:275380 6/22 (27%)
leucine-rich repeat 475..497 CDD:275380 7/24 (29%)
LRR 18 475..496 7/23 (30%)
LRR 19 497..520 8/22 (36%)
leucine-rich repeat 499..520 CDD:275380 7/20 (35%)
LRRCT 529..582 CDD:214507 16/71 (23%)
TIR 641..780 CDD:214587 38/147 (26%)
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:404697
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..201 CDD:275380
LRR 210..592 CDD:443914 53/172 (31%)
leucine-rich repeat 212..236 CDD:275380
leucine-rich repeat 237..260 CDD:275380
leucine-rich repeat 261..284 CDD:275380
leucine-rich repeat 285..308 CDD:275380
leucine-rich repeat 309..334 CDD:275380
leucine-rich repeat 335..358 CDD:275380
leucine-rich repeat 359..382 CDD:275380
leucine-rich repeat 383..406 CDD:275380