Protein Alignment TLR6 and rdo

DIOPT Version :10

• Sequence 1: NP_006059.2
• Gene: TLR6 / 10333
• HGNCID: 16711
• Length: 796
• Species: Homo sapiens
• Sequence 2: NP_001286024.1
• Gene: rdo / 35077
• FlyBaseID: FBgn0243486
• Length: 757
• Species: Drosophila melanogaster
• Alignment Length: 682
• Identity: 131/682 - (19%)
• Similarity: 245/682 - (35%)
• Gaps: 230/682 - (33%)

Human    18 MIIIVGTRIQFSDGNEFAVDKSKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLR 82
            :|||.|.|      |...:..:.|..        :|.::|.::.:.:..:.......|..|.:|.
  Fly    62 VIIIRGPR------NSITIGPALRQF--------MKLEILRITDSNLPAIGAESFWGLKYLRILD 112

Human    83 LSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPIVSFRH------LDLSFNDFKALPICKE 141
            ||.|.|..:..:.|:...:|..||||.|::.:::..   :|||      |:|:.|....| :.:.
  Fly   113 LSKNNITNITENNFRGQDNLLELDLSKNKVLRMASS---TFRHLTDLRRLNLADNSIVEL-VQRN 173

Human   142 FGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYI-LLDLRNYYIKENETESLQILNAKTLHLVFHP 205
            |..||:|.:|.||...||  ||.|.....:..: :|..||..:|:...:...:|...:
  Fly   174 FFMLSRLKYLDLSGNPLQ--DLQPDVFRDVPELKVLKCRNCQLKKINPQMYNLLPLLS------- 229

Human   206 TSLFAIQVNISVNTLGCL---------QLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIET 261
                  ::::..|....|         :||.:.|:.:...|.:..|..:.:       :|||::.
  Fly   230 ------ELDLGRNEFKFLDKDEFRDVKRLTKVLLDGNQLSVVVDQLFRMQK-------SLNHLDL 281

Human   262 TWKCLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYSK-TTLKALTIEHITNQVFLFSQTALY 325
            ::..|.:|     |.. .:|.:.|||.:      |.:|:| ..|:..:|..::|
  Fly   282 SYNRLAKV-----PND-SFLQLTNLTFL------DLSYNKLVRLEPQSIRSLSN----------- 323

Human   326 TVFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLNFTQNVFTDSIFEKCSTLV-----KLETLILQ 385
                     :||::.:..:.|.......||:.|.:       ..|..||.|.     :|..|.:.
  Fly   324 ---------LLTLNISGNVLMDLREMRETFEPLIY-------YFFLTCSKLFFQLIPQLTHLAIA 372

Human   386 KNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLSSNMLTDSVFRCLPP 450
            ..|   ...|||:                     |.     .:.:..||:|.|.|.::....:.|
  Fly   373 DMG---TMPVGLL---------------------HP-----FKQLRYLNISGNSLNNTALEVIDP 408

Human   451 --RIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSAD 513
              .::.|||..|::..:                                             |.|
  Fly   409 CRELEFLDLSRNQLHGI---------------------------------------------SED 428

Human   514 FFQSCQKMRSIKAGDNPFQC-TCELREFVKNIDQVSSEVLEGWPDSYK-CDYPESYRGSPLKDFH 576
            .....|.:|:::..:||..| .|.:.:.:..:.|:..:    | |:|. |..|:|.||:.:.:..
  Fly   429 TVLRIQGIRNVRLDNNPLICDECHMGKLINVVRQLQWK----W-DTYPICFLPKSLRGAEINNLD 488

Human   577 MSELSCNITLL----------------------IVTIGATMLVL-AVTVTSLCIYLDLPWYLRMV 618
            ::.|...:|.:                      :..:|..:.|| ||.:.||           :.
  Fly   489 INGLHTCLTFITDEEQNAASTSYNFLEHGGLNTLAILGGIIFVLIAVIILSL-----------VA 542

Human   619 CQWTQTRRRARNIPLEE---------LQRNLQ 641
            |   .::.|||....|:         |::||:
  Fly   543 C---FSKNRARYYTREDHLNGSESKCLEKNLE 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TLR6	NP_006059.2	leucine-rich repeat	36..53	CDD:275380	1/16 (6%)
		leucine-rich repeat	54..77	CDD:275378	2/22 (9%)
		LRR 1	54..77		2/22 (9%)
		LRR	<55..327	CDD:443914	62/288 (22%)
		leucine-rich repeat	78..101	CDD:275378	7/22 (32%)
		LRR 2	78..101		7/22 (32%)
		leucine-rich repeat	102..122	CDD:275378	6/19 (32%)
		LRR 3	102..122		6/19 (32%)
		leucine-rich repeat	123..147	CDD:275378	9/29 (31%)
		LRR 4	123..147		9/29 (31%)
		LRR 5	148..168		9/19 (47%)
		leucine-rich repeat	148..161	CDD:275378	6/12 (50%)
		LRR 6	169..196		5/27 (19%)
		leucine-rich repeat	174..196	CDD:275380	5/22 (23%)
		LRR 7	197..219		0/21 (0%)
		LRR 8	220..250		6/38 (16%)
		LRR	249..>531	CDD:443914	48/289 (17%)
		LRR 9	251..277		6/25 (24%)
		LRR 10	278..303		7/25 (28%)
		LRR 11	304..330		3/25 (12%)
		LRR 12	331..354		3/22 (14%)
		LRR 13	355..378		6/27 (22%)
		leucine-rich repeat	379..404	CDD:275380	6/24 (25%)
		LRR 14	379..404		6/24 (25%)
		leucine-rich repeat	405..429	CDD:275380	1/23 (4%)
		LRR 15	405..429		1/23 (4%)
		leucine-rich repeat	430..451	CDD:275380	6/22 (27%)
		LRR 16	430..450		5/19 (26%)
		LRR 17	451..474		4/22 (18%)
		leucine-rich repeat	452..474	CDD:275380	4/21 (19%)
		leucine-rich repeat	475..497	CDD:275380	0/21 (0%)
		LRR 18	475..496		0/20 (0%)
		LRR 19	497..520		2/22 (9%)
		leucine-rich repeat	499..520	CDD:275380	2/20 (10%)
		LRRCT	529..582	CDD:214507	14/54 (26%)
		TIR	641..780	CDD:214587	0/1 (0%)
rdo	NP_001286024.1	LRR	69..>446	CDD:443914	98/529 (19%)
		leucine-rich repeat	84..107	CDD:275380	2/22 (9%)
		leucine-rich repeat	108..131	CDD:275380	7/22 (32%)
		leucine-rich repeat	132..155	CDD:275380	9/25 (36%)
		leucine-rich repeat	156..179	CDD:275380	6/23 (26%)
		leucine-rich repeat	180..203	CDD:275380	9/24 (38%)
		leucine-rich repeat	204..251	CDD:275380	7/59 (12%)
		leucine-rich repeat	252..275	CDD:275380	5/29 (17%)
		leucine-rich repeat	276..299	CDD:275380	7/28 (25%)
		leucine-rich repeat	300..323	CDD:275380	7/28 (25%)
		leucine-rich repeat	388..411	CDD:275380	6/22 (27%)