DRSC/TRiP Functional Genomics Resources

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Protein Alignment TLR6 and Tehao

DIOPT Version :10

Sequence 1:NP_006059.2 Gene:TLR6 / 10333 HGNCID:16711 Length:796 Species:Homo sapiens
Sequence 2:NP_477438.1 Gene:Tehao / 34761 FlyBaseID:FBgn0026760 Length:795 Species:Drosophila melanogaster


Alignment Length:794 Identity:176/794 - (22%)
Similarity:300/794 - (37%) Gaps:215/794 - (27%)


- Green bases have known domain annotations that are detailed below.


Human   139 CKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYILLDLRNYYIKENETESLQILNAKTLHLVF 203
            |...||:.:.:.....||.|:..:  |.|.|::|         |....|.:.|...|..:|..:.
  Fly    40 CAAEGNVVRFHCPDEYAMLLEVSE--PGASLYMS---------YYASTELQWLPRFNISSLVKIE 93

Human   204 HPTSLFAIQVNIS--VNTLGCLQLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIE------ 260
            ....:|..:..:|  :.|||...:..|...|...:..:      ||  .:||....::|      
  Fly    94 FDAYIFWPEKFLSDLLKTLGVQTVKTIIFRDRTLETVV------TR--DVLNSGNGYMETSQPEN 150

Human   261 -TTWKC----LVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYSKT------------TLKALT 308
             |||..    .::.|:|....|....:|::  ..:::|:...:.:.|            |||.||
  Fly   151 ITTWHFGSVPGLKKFKFFSHVPELQESIFH--GFDTLRDLHLSVNVTTLPGNMLSTVNGTLKTLT 213

Human   309 IEHITNQVFLFSQTALYTVFSEMNIMMLTISDTPFIH----MLCPHAPSTF------KFLNFTQN 363
            ||  :..:..|....|..:....|:.:..|.  || |    .|.||...:.      :..:.|.:
  Fly   214 IE--SPGIVSFGNPLLRELQQLRNLSLALIH--PF-HERDKQLQPHFFGSMTNLEEVRLASATSS 273

Human   364 VFTDSIFEKCSTLVKLETLILQKNGLKDLFKV-GLMTKDMPSLEILDVSWNSLESGRHKENCTWV 427
            | ..|:|:..:   ||:  :::.||..||.:: |.:..|..:|:.||:|.|::.: .|::....:
  Fly   274 V-NRSMFKGTN---KLQ--LIKMNGNDDLMELPGEIFLDQVNLKTLDLSCNAIVT-LHEDVFKGL 331

Human   428 ESIVVLNLSSNMLTD---SVFRCLPPRIKVLDLHSNKI----KSVPKQVVKLEALQELNVAF--- 482
            .::.:|:||.|.||:   ::|..| ..:.||.|:.|.:    .||.:.||.|..::.:|..|   
  Fly   332 GNLTLLDLSKNRLTNLSSTIFAPL-TSLNVLRLNKNSLTAMSPSVFQDVVSLNYIEMVNTQFYGA 395

Human   483 ----------------------------------------------------------------- 482
                                                                             
  Fly   396 TLLMNYEAVVCTNDEACQYKSAEWQCDPRCICWVQRSVGSLIVDCRGTSLEELPDLPRTTLLSTV 460

Human   483 -----NSLTDLPGCGSFSSLS----VLIIDHNSVSHPSAD------------------------- 513
                 ||||.||.....|..:    :.:.|:|..|..|.|                         
  Fly   461 LKVGNNSLTSLPTVSEHSGYANVSGLFLSDNNLTSLGSGDQLPDNLTHLDVRGNQIQSLSDEFLL 525

Human   514 FFQSCQKMRSIKAGDNPFQCTCE---LREFVKNIDQVSSEVLEGWPDSYKCDYPESYRGSPLKDF 575
            |.|......::....||..|.||   |..||:...|...::         .|...:.:....:..
  Fly   526 FLQEPNNTMTLSLSGNPITCGCESLSLLFFVRTNPQRVRDI---------ADIVCTKQKKSFQQM 581

Human   576 HMSELSCNITLLI--VTIGATMLVLAVTVTSLCIYLDLP-W-YLRMVCQWTQTRRRARNIPLEEL 636
            ...||..:..|||  |..|..:::..:||..|....:|. | |...:|.|.        :..|||
  Fly   582 EAFELCPSYVLLISCVVGGLVIVICLLTVFYLMFQQELKIWLYNNNLCLWW--------VSEEEL 638

Human   637 QRNLQFHAFISYSEHDSAWVKSELVPYLEK--EDIQICLHERNFVPGKSIVENIINCIEKSYKSI 699
            .::..:.||||||..|...: |:|:|.||.  ...::|||:|:::.|..|.|.|:..::.|.:.|
  Fly   639 DKDKTYDAFISYSHKDEELI-SKLLPKLESGPHPFRLCLHDRDWLVGDCIPEQIVRTVDDSKRVI 702

Human   700 FVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILILLEPIP-QNSIPNKYHKLKALMTQRTYLQW 763
            .|||.:|:.|.|...|...|:.....:....:|:||...:. .|.|.:   :|:|.:...|||:|
  Fly   703 IVLSQHFIDSVWARMEFRIAYQATLQDKRKRIIIILYRELEHMNGIDS---ELRAYLKLNTYLKW 764

Human   764 PKEKSKRGLFWANI 777
            ...     |||:.:
  Fly   765 GDP-----LFWSKL 773

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TLR6NP_006059.2 leucine-rich repeat 36..53 CDD:275380
leucine-rich repeat 54..77 CDD:275378
LRR 1 54..77
LRR <55..327 CDD:443914 45/212 (21%)
leucine-rich repeat 78..101 CDD:275378
LRR 2 78..101
leucine-rich repeat 102..122 CDD:275378
LRR 3 102..122
leucine-rich repeat 123..147 CDD:275378 3/7 (43%)
LRR 4 123..147 3/7 (43%)
LRR 5 148..168 4/19 (21%)
leucine-rich repeat 148..161 CDD:275378 3/12 (25%)
LRR 6 169..196 5/26 (19%)
leucine-rich repeat 174..196 CDD:275380 3/21 (14%)
LRR 7 197..219 3/23 (13%)
LRR 8 220..250 6/29 (21%)
LRR 249..>531 CDD:443914 81/424 (19%)
LRR 9 251..277 8/36 (22%)
LRR 10 278..303 3/36 (8%)
LRR 11 304..330 8/25 (32%)
LRR 12 331..354 8/26 (31%)
LRR 13 355..378 4/28 (14%)
leucine-rich repeat 379..404 CDD:275380 7/25 (28%)
LRR 14 379..404 7/25 (28%)
leucine-rich repeat 405..429 CDD:275380 6/23 (26%)
LRR 15 405..429 6/23 (26%)
leucine-rich repeat 430..451 CDD:275380 8/23 (35%)
LRR 16 430..450 8/22 (36%)
LRR 17 451..474 9/26 (35%)
leucine-rich repeat 452..474 CDD:275380 9/25 (36%)
leucine-rich repeat 475..497 CDD:275380 9/94 (10%)
LRR 18 475..496 8/93 (9%)
LRR 19 497..520 7/51 (14%)
leucine-rich repeat 499..520 CDD:275380 7/45 (16%)
LRRCT 529..582 CDD:214507 12/55 (22%)
TIR 641..780 CDD:214587 44/140 (31%)
TehaoNP_477438.1 LRR 184..>541 CDD:443914 70/369 (19%)
leucine-rich repeat 185..207 CDD:275380 2/21 (10%)
leucine-rich repeat 209..232 CDD:275380 8/24 (33%)
leucine-rich repeat 233..261 CDD:275380 8/30 (27%)
leucine-rich repeat 262..284 CDD:275380 4/25 (16%)
leucine-rich repeat 285..309 CDD:275380 7/25 (28%)
leucine-rich repeat 310..333 CDD:275380 6/23 (26%)
leucine-rich repeat 334..357 CDD:275380 8/23 (35%)
leucine-rich repeat 358..381 CDD:275380 7/22 (32%)
leucine-rich repeat 445..482 CDD:275380 7/36 (19%)
leucine-rich repeat 483..505 CDD:275380 5/21 (24%)
TIR 643..779 CDD:214587 44/140 (31%)
Blue background indicates that the domain is not in the aligned region.

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