DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TLR6 and Toll-4

DIOPT Version :9

Sequence 1:	NP_001381482.1	Gene:	TLR6 / 10333	HGNCID:	16711	Length:	796	Species:	Homo sapiens
Sequence 2:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster

Alignment Length:	874	Identity:	172/874 - (19%)
Similarity:	313/874 - (35%)	Gaps:	291/874 - (33%)

- Green bases have known domain annotations that are detailed below.

Human    30 DGNEFAVDKSKRGLIHVPKDLPLKTK---VLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLL 91
            |.::..:|..::.|..:| .||:..|   .|....|.:|||..:.:.....|..|.:|:|  ||.
  Fly   383 DKSQLEIDCWQKNLTTIP-SLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLDVSYN--QLT 444

Human    92 DLSVFKFNQDLEYLDLSHNQLQKISCHPIVSFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSAM 156
            .|||.:..:.|.|||:.||::..:| ..:|.:.:   |.|.|      .::||...:
  Fly   445 SLSVSQLPESLHYLDIRHNKITTLS-PQVVEYLY---SVNVF------NQYGNKWSI-------- 491

Human   157 KLQKLDLLPIAHLHLSYILLDLRNYYIKENETESLQILNAKTLHLVFHPTSLFAIQVNISVNTLG 221
                                     |..|...:......||.|.:   .||.|
  Fly   492 -------------------------YCDEYHLQEFFWYKAKLLRI---KTSKF------------ 516

Human   222 CLQLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNL 286
                          |..::::...::||.:.||.:.:|:..                 ||.....
  Fly   517 --------------QTIMEYIELSSKGSFVENFFVQNIDQL-----------------YLEANED 550

Human   287 TIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTVFSEMNIMMLTISDTPFIHMLCPHA 351
            .||::....|..::...::||     .:.::|||        .|.:.::|...::|     ||:.
  Fly   551 EIIDAFGPSDKYFNLKLMEAL-----NHAIWLFS--------GEFDEIILHHLNSP-----CPYR 597

Human   352 PS------TFKFLNFTQNVFTDSIFEKCSTLVKLE-TLILQKNGLKDLFKV-GLMTKDMPSLEIL 408
            .|      |.:||...:|:..| |:.:....:..: ||.|.:|.::.|... .|:.....|:..|
  Fly   598 CSCCFEWHTGEFLINCRNLSLD-IYPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHASIHKL 661

Human   409 DVSWNSL-ESGRH--KENCTWV---------------------ESIVVLNLSSN----------- 438
            .:|.|.| |...|  .||.|::                     |:|..:.||.|
  Fly   662 HMSQNLLRELPLHLLPENITYLDVRNNLLKYLDDGVIAFLEYRENITKIELSGNPWECNCKAKAF 726

Human   439 ---------MLTDSVFRCLPPRIK------------------------VLDLHSNKIKSVPKQVV 470
                     |..::|.|    |::                        |:|....::..:|:...
  Fly   727 LSFLRRHEPMEYETVLR----RVEITDDKCPEDCICCVDTSNSDSLAYVVDCSGKELSEIPQLPT 787

Human   471 KLEALQELNVAFNSLTD-----LPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGD-- 528
            .......|....|||..     |||   :||::...:.||.:|    |..|...|:..:...:
  Fly   788 PTYGQTTLVFERNSLKKWPSSLLPG---YSSVTRFYLAHNRLS----DIDQLPDKLEYLDISNNN 845

Human   529 ---------------------------NPFQCTCELREFV-------KNIDQVSSEVLEGWPDSY 559
                                       ||:.|.||.::|:       |||...|         :.
  Fly   846 FSALDDRVRGFLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNIANAS---------AI 901

Human   560 KC-DYPESYRGSPLKDFHMSELSCNITLLIVTIGATMLVLAVTVTSLCIYLD--LPW-YLRMVCQ 620
            :| |     .|..|.:...:::..::.:...::..::|::|:::.....:..  :.| |...:|.
  Fly   902 QCID-----TGRSLIEVEETDICPSVLIYYTSLAVSLLIIALSINVFICFRQPIMIWFYEHEICL 961

Human   621 WTQTRRRARNIPLEELQRNLQFHAFISYSEHDSAWVKSELVPYLE--KEDIQICLHERNFVPGKS 683
            ....||        ||..:.::.||:|::..|...:: |.|..||  :...::|.:.|:::.|:|
  Fly   962 SLAARR--------ELDEDKKYDAFLSFTHKDEDLIE-EFVDRLENGRHKFRLCFYLRDWLVGES 1017

Human   684 IVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILILLEPIPQNSIPNKY 748
            |.:.|...::.|.:.|.:::.||::|.|...|...|.|....:....||::|        .|:..
  Fly  1018 IPDCINQSVKGSRRIIILMTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVL--------YPDVE 1074

Human   749 H------KLKALMTQRTYLQ------WPK 765
            |      :|:|.|...|||.      |.|
  Fly  1075 HFDDLDSELRAYMVLNTYLDRNNPNFWNK 1103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TLR6	NP_001381482.1	LRR 1	54..77		6/25 (24%)
		LRR 2	78..101		9/22 (41%)
		LRR 3	102..122		7/19 (37%)
		LRR 4	123..147		5/23 (22%)
		LRR 5	148..168		0/19 (0%)
		LRR 6	169..196		2/26 (8%)
		LRR 7	197..219		5/21 (24%)
		LRR 8	220..250		2/29 (7%)
		LRR 9	251..277		3/25 (12%)
		LRR 10	278..303		5/24 (21%)
		LRR 11	304..330		5/25 (20%)
		LRR 12	331..354		5/28 (18%)
		LRR 13	355..378		5/22 (23%)
		LRR 14	379..404		6/26 (23%)
		LRR 15	405..429		9/47 (19%)
		LRR 16	430..450		7/39 (18%)
		LRR 17	451..474		4/46 (9%)
		LRR 18	475..496		7/25 (28%)
		LRR 19	497..520		5/22 (23%)
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380
		leucine-rich repeat	288..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..386	CDD:275380	1/2 (50%)
		leucine-rich repeat	388..408	CDD:275380	5/20 (25%)
		LRR_8	412..465	CDD:290566	20/54 (37%)
		leucine-rich repeat	412..432	CDD:275378	5/19 (26%)
		LRR_4	432..470	CDD:289563	16/40 (40%)
		leucine-rich repeat	433..454	CDD:275378	9/22 (41%)
		leucine-rich repeat	455..478	CDD:275378	8/26 (31%)
		leucine-rich repeat	479..490	CDD:275378	4/16 (25%)
		leucine-rich repeat	632..657	CDD:275378	6/24 (25%)
		leucine-rich repeat	658..679	CDD:275378	6/20 (30%)
		leucine-rich repeat	680..706	CDD:275378	1/25 (4%)
		leucine-rich repeat	707..719	CDD:275378	4/11 (36%)
		leucine-rich repeat	771..791	CDD:275380	3/19 (16%)
		leucine-rich repeat	793..815	CDD:275378	7/24 (29%)
		leucine-rich repeat	816..835	CDD:275378	5/22 (23%)
		leucine-rich repeat	836..859	CDD:275378	0/22 (0%)
		TIR	974..1110	CDD:214587	36/139 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920