DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CNPY2 and sel

DIOPT Version :9

Sequence 1:	NP_055070.1	Gene:	CNPY2 / 10330	HGNCID:	13529	Length:	182	Species:	Homo sapiens
Sequence 2:	NP_610547.1	Gene:	sel / 36046	FlyBaseID:	FBgn0263260	Length:	189	Species:	Drosophila melanogaster

Alignment Length:	174	Identity:	52/174 - (29%)
Similarity:	98/174 - (56%)	Gaps:	10/174 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     8 ALLLGALLGTA--WARRSQDLHCGACRALVDELEWEIAQVDPKKTIQMGSFRINPDGSQSVVEVP 70
            ||:|..||..|  ::..|:::.|..|:|:|.|||..||:.||.|...:..||::..|:....:|.
  Fly     5 ALILFGLLALAQGYSFTSREVKCHVCKAVVTELEEAIAKEDPHKMADVSGFRLDAQGNSISKKVR 69

Human    71 YARSEAHLTELLEEICDRMKEYGEQIDPSTHRKNYVRVV--GR-NGESSELDLQGIRIDSDISGT 132
            ..:||..||||:|:||::|.:|.:....|..:...::::  |: |.:||.:|...   |.|::.:
  Fly    70 LVKSEMFLTELMEKICEKMDDYLKATYKSNGKFTLLKMIINGQMNPDSSLVDFVQ---DGDLNKS 131

Human   133 LKFACESIVEEYEDELIEFFSRE--ADNVKDKLCSKRTDLCDHA 174
            |...|..::|:.::..::.|..|  .:::..|:||::...||.:
  Fly   132 LGHFCNEVLEDNDEIFVKAFQAEELGNDLDIKICSEQASYCDES 175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CNPY2	NP_055070.1	DUF3456	27..165	CDD:403222	41/142 (29%)
CNPY2	NP_055070.1	Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	179..182
sel	NP_610547.1	DUF3456	26..166	CDD:288766	41/142 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I9010
eggNOG	1	0.900	-	-		E1_KOG3782
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	84	1.000	Inparanoid score	I5184
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48415
OrthoDB	1	1.010	-	-		D1417418at2759
OrthoFinder	1	1.000	-	-		FOG0003185
OrthoInspector	1	1.000	-	-		oto90486
orthoMCL	1	0.900	-	-		OOG6_105647
Panther	1	1.100	-	-	LDO	PTHR13341
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4170
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.870