DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SMYD5 and Smyd5

DIOPT Version :9

Sequence 1:	NP_006053.2	Gene:	SMYD5 / 10322	HGNCID:	16258	Length:	418	Species:	Homo sapiens
Sequence 2:	NP_650955.1	Gene:	Smyd5 / 42517	FlyBaseID:	FBgn0038869	Length:	393	Species:	Drosophila melanogaster

Alignment Length:	381	Identity:	179/381 - (46%)
Similarity:	244/381 - (64%)	Gaps:	6/381 - (1%)

- Green bases have known domain annotations that are detailed below.

Human    32 KGKGLFATQLIRKGETIFVERPLVAAQFLWNALYRYRACDHCLRALEKAEENAQRLTGKPGQVLP 96
            ||:.:.||:...|.|.||.|.|.|:.||.||..|.|.|||||:|.||...||.:||...|...:|
  Fly    12 KGRAMIATKNFAKDEVIFEEEPFVSRQFSWNVAYGYAACDHCMRPLETVLENVRRLASDPKVEVP 76

Human    97 ----HPELCTVRKDLHQNCPHCQVMYCSAECRLAATEQYHQVLCPGPSQDDPLHPLNKLQEAWRS 157
                .|....|.:  ...||.|:|.|||.:|.:.|.::||:|.|.|....|..||:|.|.|.|:.
  Fly    77 LLQHDPTAQWVAQ--FTQCPRCKVRYCSEDCLMEAQKRYHRVACMGAFHSDDTHPINVLNETWKK 139

Human   158 IHYPPETASIMLMARMVATVKQAKDKDRWIRLFSQFCNKTANEEEEIVHKLLGDKFKGQLELLRR 222
            :||||||.||||:.|::|..:|:..|:.::.....|.:...|.|::|.||:||:.|:.|:|.|..
  Fly   140 MHYPPETGSIMLIVRLMALYQQSTKKEEFLEQLQSFQSLIVNREQKIYHKMLGENFEQQMEQLYL 204

Human   223 LFTEALYEEAVSQWFTPDGFRSLFALVGTNGQGIGTSSLSQWVHACDTLELKPQDREQLDAFIDQ 287
            .|..|...|..|.:.|||.|::|.|::|||.|||.||.|||||.....|.|...::||||..||.
  Fly   205 AFCNAFTGEEFSIFKTPDAFKTLMAILGTNSQGIATSVLSQWVAKVSDLPLTDSEKEQLDTVIDG 269

Human   288 LYKDIEAATGEFLNCEGSGLFVLQSCCNHSCVPNAETSFPENNFLLHVTALEDIKPGEEICISYL 352
            ||..:....|||||.|||||::|||..||||||||.::||.:|.::.:.||..|:.|||||||||
  Fly   270 LYAKVGEFAGEFLNNEGSGLYLLQSKINHSCVPNACSTFPYSNDIVVLKALAPIQQGEEICISYL 334

Human   353 DCCQRERSRHSRHKILRENYLFVCSCPKCLAEADEPNVTSEEEEEEEEEEEGEPED 408
            |.|..|||||||||:|||||:|:|.||||.|:|.:|:.|||::::::|.::.:.:|
  Fly   335 DECMLERSRHSRHKVLRENYVFICQCPKCRAQASDPDETSEDDDDDDEMDDYDDDD 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMYD5	NP_006053.2	SET	<298..351	CDD:214614	32/52 (62%)
SMYD5	NP_006053.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..418		7/24 (29%)
Smyd5	NP_650955.1	zf-MYND	87..118	CDD:280009	13/32 (41%)
Smyd5	NP_650955.1	SET	<296..333	CDD:279228	20/36 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143276
Domainoid	1	1.000	291	1.000	Domainoid score	I1548
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6143
Inparanoid	1	1.050	368	1.000	Inparanoid score	I2154
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52484
OrthoDB	1	1.010	-	-		D1001347at2759
OrthoFinder	1	1.000	-	-		FOG0005444
OrthoInspector	1	1.000	-	-		oto90476
orthoMCL	1	0.900	-	-		OOG6_104425
Panther	1	1.100	-	-	LDO	PTHR46402
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5378
SonicParanoid	1	1.000	-	-		X5016
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800