DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMYD5 and SmydA-2

DIOPT Version :9

Sequence 1:	NP_006053.2	Gene:	SMYD5 / 10322	HGNCID:	16258	Length:	418	Species:	Homo sapiens
Sequence 2:	NP_649084.1	Gene:	SmydA-2 / 40075	FlyBaseID:	FBgn0036839	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	362	Identity:	88/362 - (24%)
Similarity:	130/362 - (35%)	Gaps:	114/362 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    33 GKGLFATQLIRKGETIFVERPLVAAQFLWNALYRYRACDHCLRALEKAEENAQRLTGKPGQVLPH 97
            |:.|.||:.|:.||.|..|.|||....:.:|    ..|..|.|.|        ...|||
  Fly    58 GRHLRATRDIKIGEQILKEAPLVLGPKVASA----PLCLGCHRNL--------LAPGKP------ 104

Human    98 PELCTVRKDLHQNCPHCQVMYCSAECRLAATEQYHQVLCPGPSQDDPLHPLNKLQEAWRSIHYPP 162
                  |.:.|: |..|....|..||.   ...:|:..|       .|...:..|.   .|:|.|
  Fly   105 ------RGNYHK-CSSCSWPLCGKECE---DSVHHKAEC-------QLMSGSNFQS---KINYVP 149

Human   163 ------ETASIMLMARMVATVKQAKDKDRWIRLFSQFCNKTANEEEEIVHKLLGDKFKGQLE--- 218
                  |:|..::|......:|. ||.|.:::|::                 |.|..|.:||
  Fly   150 GEEERKESAYCVIMLLRCMHLKD-KDPDAFLKLYN-----------------LEDHLKERLETPL 196

Human   219 ---LLRRLFTEALYEEAVSQWFTPDGFRSLFALVGTNGQGIGTSSLSQWVHACDTLELK-PQDRE 279
               |...|.|.......:..|...|..| :.|::.||                 |.|:: |::|.
  Fly   197 YQVLRANLITFIKTVLGMKDWPEMDILR-IAAILDTN-----------------TFEVRQPRERR 243

Human   280 QLDAFIDQLYKDIEAATGEFLNCEGSGLFVLQSCCNHSCVPNAETSFPENNFLLHVTALEDIKPG 344
            ::.|    ||             .|:.:.      :|.||||....|.::..::.: |...|..|
  Fly   244 KIRA----LY-------------PGAAMI------SHDCVPNMRHRFDDDMNIVFL-AKRKIAKG 284

Human   345 EEICISYLDCCQRERSRHSRHKILRENYLFVCSCPKC 381
            |.:.|||   .|..||...|...||:...|.|||.:|
  Fly   285 EILSISY---TQPLRSTIQRRVHLRQAKCFDCSCARC 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMYD5	NP_006053.2	SET	<298..351	CDD:214614	12/52 (23%)
SMYD5	NP_006053.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..418
SmydA-2	NP_649084.1	zf-MYND	9..46	CDD:280009
SmydA-2	NP_649084.1	SET	<246..291	CDD:214614	15/68 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810