Protein Alignment SMYD5 and Smyd4-4

DIOPT Version :10

• Sequence 1: NP_006053.2
• Gene: SMYD5 / 10322
• HGNCID: 16258
• Length: 418
• Species: Homo sapiens
• Sequence 2: NP_610730.1
• Gene: Smyd4-4 / 36299
• FlyBaseID: FBgn0027495
• Length: 573
• Species: Drosophila melanogaster
• Alignment Length: 410
• Identity: 94/410 - (22%)
• Similarity: 142/410 - (34%)
• Gaps: 129/410 - (31%)

Human    29 SSAKGKGLFATQLIRKGETIFVERPLVAAQFLWNALYRYRACDHCLRALEKAEENAQRLTGKPGQ 93
            ::|:|:.:...:.:..|:.:.||.|..:...   ...||..|..|.|      ||...|
  Fly   192 TAAEGRFVVTNRDLAVGDLVSVEEPFCSTLL---TPMRYIRCATCKR------ENYLTL------ 241

Human    94 VLPHPELCTVRKDLHQNCPHCQVMYCSAECRLAATEQYHQVLCPGPSQDDPLHPLNKLQEAWRSI 158
             :|    |       .:|  |..|:||.||:..|.:.||:..||         .::.|...:..|
  Fly   242 -IP----C-------DSC--CSTMFCSEECKSIAMQTYHRYECP---------IIDFLNRMFNKI 283

Human   159 HYPPETASIMLMARMVA-----TVKQAKDKDRWIRLFSQFCNKTANEEEEIVHKLLGDKFKGQLE 218
            |      .|.|...:||     ::::..|          ||.:..|:          ||....|.
  Fly   284 H------CIALRTTLVALNIFPSIEELID----------FCEQEQNQ----------DKCAFDLN 322

Human   219 LLRRLFTEALYEEAVSQWFTP-DGFRSLFALVGTNGQGIGTSSLSQWVHACDTL-----ELKP-- 275
                      |.|     .|| :.:|::..|| ||......|.|.|....|..|     |..|
  Fly   323 ----------YNE-----LTPEEHYRAIHGLV-TNQHLRSVSDLFQRSVVCAVLKHFIIEYTPVK 371

Human   276 ---QDREQLDAFIDQLYKDIEAATG--------EFLN------CEGSGLFVLQSCCNHSCVPNAE 323
               ...|.::.|.|.|::.::.:..        |.:|      ...||.:...|..||||.||..
  Fly   372 EYLGGEEGVNFFTDLLFRHLQTSPSNMHGIDLVEQVNETKDDQTHSSGAYAFLSLINHSCAPNTV 436

Human   324 TSFPENNFLLHVTALEDIKPGEEICISY---LDCCQRERSRHSRHKILRENYLFVCSCPKCLA-- 383
            ..:......:.|  |..||.|..:..:|   ...|.:|:    |.|.|...|.|.|.|..|..
  Fly   437 RIYEGTKAYMFV--LRPIKAGNVLYDNYGAHFAICSKEQ----RLKRLSLQYRFDCKCEGCELNY 495

Human   384 --------EADEPNVTSEEE 395
                    :|..|:||.:.|
  Fly   496 PMFGMMPHKATVPSVTDDTE 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMYD5	NP_006053.2	SET_SMYD5	22..384	CDD:380919	89/397 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	385..418		5/11 (45%)
Smyd4-4	NP_610730.1	SET_SMYD4	180..491	CDD:380934	88/384 (23%)
		zf-MYND	230..270	CDD:460312	18/65 (28%)