DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SMYD5 and Smyd4-4

DIOPT Version :9

Sequence 1:	NP_006053.2	Gene:	SMYD5 / 10322	HGNCID:	16258	Length:	418	Species:	Homo sapiens
Sequence 2:	NP_610730.1	Gene:	Smyd4-4 / 36299	FlyBaseID:	FBgn0027495	Length:	573	Species:	Drosophila melanogaster

Alignment Length:	410	Identity:	94/410 - (22%)
Similarity:	142/410 - (34%)	Gaps:	129/410 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    29 SSAKGKGLFATQLIRKGETIFVERPLVAAQFLWNALYRYRACDHCLRALEKAEENAQRLTGKPGQ 93
            ::|:|:.:...:.:..|:.:.||.|..:...   ...||..|..|.|      ||...|
  Fly   192 TAAEGRFVVTNRDLAVGDLVSVEEPFCSTLL---TPMRYIRCATCKR------ENYLTL------ 241

Human    94 VLPHPELCTVRKDLHQNCPHCQVMYCSAECRLAATEQYHQVLCPGPSQDDPLHPLNKLQEAWRSI 158
             :|    |       .:|  |..|:||.||:..|.:.||:..||         .::.|...:..|
  Fly   242 -IP----C-------DSC--CSTMFCSEECKSIAMQTYHRYECP---------IIDFLNRMFNKI 283

Human   159 HYPPETASIMLMARMVA-----TVKQAKDKDRWIRLFSQFCNKTANEEEEIVHKLLGDKFKGQLE 218
            |      .|.|...:||     ::::..|          ||.:..|:          ||....|.
  Fly   284 H------CIALRTTLVALNIFPSIEELID----------FCEQEQNQ----------DKCAFDLN 322

Human   219 LLRRLFTEALYEEAVSQWFTP-DGFRSLFALVGTNGQGIGTSSLSQWVHACDTL-----ELKP-- 275
                      |.|     .|| :.:|::..|| ||......|.|.|....|..|     |..|
  Fly   323 ----------YNE-----LTPEEHYRAIHGLV-TNQHLRSVSDLFQRSVVCAVLKHFIIEYTPVK 371

Human   276 ---QDREQLDAFIDQLYKDIEAATG--------EFLN------CEGSGLFVLQSCCNHSCVPNAE 323
               ...|.::.|.|.|::.::.:..        |.:|      ...||.:...|..||||.||..
  Fly   372 EYLGGEEGVNFFTDLLFRHLQTSPSNMHGIDLVEQVNETKDDQTHSSGAYAFLSLINHSCAPNTV 436

Human   324 TSFPENNFLLHVTALEDIKPGEEICISY---LDCCQRERSRHSRHKILRENYLFVCSCPKCLA-- 383
            ..:......:.|  |..||.|..:..:|   ...|.:|:    |.|.|...|.|.|.|..|..
  Fly   437 RIYEGTKAYMFV--LRPIKAGNVLYDNYGAHFAICSKEQ----RLKRLSLQYRFDCKCEGCELNY 495

Human   384 --------EADEPNVTSEEE 395
                    :|..|:||.:.|
  Fly   496 PMFGMMPHKATVPSVTDDTE 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SMYD5	NP_006053.2	SET	<298..351	CDD:214614	16/58 (28%)
SMYD5	NP_006053.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..418		5/11 (45%)
Smyd4-4	NP_610730.1	TPR_11	67..138	CDD:290150
		zf-MYND	230..270	CDD:280009	18/65 (28%)
		SET	363..463	CDD:279228	22/101 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810