Protein Alignment SMYD5 and Smyd4-1

DIOPT Version :10

• Sequence 1: NP_006053.2
• Gene: SMYD5 / 10322
• HGNCID: 16258
• Length: 418
• Species: Homo sapiens
• Sequence 2: NP_610500.2
• Gene: Smyd4-1 / 35985
• FlyBaseID: FBgn0033427
• Length: 751
• Species: Drosophila melanogaster
• Alignment Length: 408
• Identity: 98/408 - (24%)
• Similarity: 148/408 - (36%)
• Gaps: 119/408 - (29%)

Human    32 KGKGLFATQLIRKGETIFVERPLVAAQFLWNALYRYRACDHCLRALEKAEENAQRLTGKPGQVLP 96
            :|:.:.|.:.|.||..||.||   |:.|:  .|.:...|..|...|..|               |
  Fly   225 RGRYMVAKEAISKGNVIFSER---ASCFV--PLEQLLICQQCAATLMSA---------------P 269

Human    97 HPELCTVRKDLHQNCPHC--QVMYCSAECRLAATEQYHQVLCPGPSQDDPLHPLNKLQEAWRSI- 158
            .|            ||:|  :|:|||.:|| .|....|:..| ...:.|.|..|.....|.|.:
  Fly   270 IP------------CPNCHQRVVYCSRKCR-EAHSAIHKFEC-AAYRKDILRLLGISHLALRLLL 320

Human   159 --------HYPPETAS------IMLMARMVATVKQAKDKDRWIRLFSQFCNKTANEEEEIVHKLL 209
                    |....|::      ||.::|.....:.|.:..|.:|:.||.  ..|.:||...|.|.
  Fly   321 TYIPYIRPHLQEMTSAKGMWEEIMNLSRKPEESENAPEYLRSLRMVSQL--DQAIDEELNYHILC 383

Human   210 GDKFKGQLELLRRLFTEALYEEAVSQWFTPDGFRSLFALVGTNGQGIGTSSLSQWV--------- 265
            .:       ||:      ||.:..:.::  |.|.||            .:|:..|.
  Fly   384 AN-------LLQ------LYLKEHTDFY--DQFHSL------------PASIEDWQLIISALILR 421

Human   266 ---------HACDTL---ELKPQDREQLDAFIDQLYKDIEAATGEFLNCEGSGLFV-----LQSC 313
                     |..|.|   .::|::...|...:.|  |......|:..|...|....     ..|.
  Fly   422 FAGQLLANGHVGDALLGVGMEPKEFVMLQPELWQ--KPRHLKRGQLHNLSHSDPITAINLPYLSL 484

Human   314 CNHSCVPNAETSFPENNFLLHVTALEDIKPGEEI--C--ISYLDCCQRERSRHSRHKILRENYLF 374
            |||:|.|:..|.|...:.:.:  |.:||..||||  |  :.|.:..:.:||..     |:..|.|
  Fly   485 CNHACEPSIRTKFDGCSVVNY--AAKDILEGEEIFNCYTMDYRNSLKLQRSHP-----LKAIYKF 542

Human   375 VCSCPKCLAEADEPNVTS 392
            .|:|.||.....:.|..|
  Fly   543 ECTCAKCTRTDPDQNYLS 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMYD5	NP_006053.2	SET_SMYD5	22..384	CDD:380919	96/398 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	385..418		2/8 (25%)
Smyd4-1	NP_610500.2	SET	217..>252	CDD:394802	11/31 (35%)
		zf-MYND	258..298	CDD:460312	17/67 (25%)
		SET	<359..549	CDD:394802	53/227 (23%)