DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LAMC3 and wb

DIOPT Version :9

Sequence 1:XP_011516423.1 Gene:LAMC3 / 10319 HGNCID:6494 Length:1581 Species:Homo sapiens
Sequence 2:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster


Alignment Length:1412 Identity:407/1412 - (28%)
Similarity:567/1412 - (40%) Gaps:408/1412 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    18 AGAGMGACYDGAGRPQRCLPVFENAAFGRL----------AQAS--HTCG-SPPEDFCPHVGAAG 69
            :|.|.|.   ||.|..:...|:.::..|.|          ||.|  .||| :..|::|..|||..
  Fly   127 SGGGAGG---GALRLLKTEDVYSSSFSGGLYPPLFNVVPRAQISVNATCGQNGAEEYCKQVGAKP 188

Human    70 AGAHCQRCDAADPQRHHNASYLTDFHSQD--------ESTWWQSPSMAFGVQYPTSVNITLRLGK 126
            .|.    |:|....|....|..:...|..        |..|||||::..|.|: ..|.|.|.|.:
  Fly   189 CGI----CNAHSSDRAKQRSIQSLISSGSGSGSGSGFEEGWWQSPTLQGGRQF-EYVTILLDLKQ 248

Human   127 AYEITYVRLKFHTS-RPESFAIYKRSRADG----PWEPYQFYSASCQKTY--GRPEGQYLRPGED 184
            .::|..|.||...| ||.|:.:.|  ..||    ||:.:....|.||:.:  ....|:|:...:.
  Fly   249 TFQIFSVWLKSANSPRPASWILEK--SLDGINFEPWQYFGLSDADCQRRWNLSGQNGKYVFQNDT 311

Human   185 ERVAFCTSEFSDISPLSGGNVAFSTLEGRPSAYNFEESPGLQEWVTSTELLISLDRLNTFG---- 245
            |.:  |:::||...||..|.:..|.|:.||.|  .::||.|.:::|:..:.|.|..:::..    
  Fly   312 EII--CSTQFSKPGPLENGVLHASLLKNRPGA--TDQSPELMKFITTRYIRIRLQGMHSTANQDN 372

Human   246 --DDIFKDPKVLQSYYYAVSDFSVGGRCKCNGHA--SECGPDVAGQLACRCQHNTTGTDCERCLP 306
              |.:...|.:.:..:|::|...|..|..|||||  |...|| ...:.|.|||||.|..||:|.|
  Fly   373 SLDWLLDSPSLEKHSFYSLSQLKVSARLDCNGHANRSHESPD-DPLMQCICQHNTCGAQCEQCCP 436

Human   307 FFQDRPWARGTAEAAHECLPCNCSGRSEECTFDRELFRSTGHGGRCHHCRDHTAGPHCERCQENF 371
            .|||||:..|     .||..|.|.|.:|.||:|..|.:     |.|..|.::|||..||.|:..|
  Fly   437 LFQDRPYQMG-----GECEICQCYGHAESCTYDPFLDK-----GICQSCSNNTAGIECEFCEMGF 491

Human   372 Y-HWDPRM--PCQPCDCQSAGSLHLQCDDTGTCACKPTVTGWKCDRCLPGFHSLSEGGCRPCTCN 433
            | ..|..:  ||.||.|..|.|......|.|:|.|.....|..|:.|.||::.   ..|:.|.|:
  Fly   492 YRELDAPLTDPCLPCSCNPARSTGGCQSDGGSCNCLEGFQGKNCEECAPGYYG---DDCKRCECD 553

Human   434 PAGSLDTCDPRSGRCPCKENVEGNLCDRCRPGTFNLQPHNPAGCSSCFCYGHSKVCAS----TAQ 494
            ..|||.:....||.|.||.||||:.|..|.||.|:|...|..||:||:|.|.|:.|.|    |..
  Fly   554 ERGSLGSTGSCSGVCQCKLNVEGSTCSECAPGYFDLSAENAEGCTSCWCSGVSQTCHSAKLQTLA 618

Human   495 FQVHHILSDFHQGAEGWW----ARSVGGSEHPPQWSPNGVLLSPE-DEEEL---TAPEKFLGDQR 551
            |:.   |:|        |    .:.|.....|.....|.::.:.| ||.|.   .|...:||::.
  Fly   619 FET---LND--------WKITDIQRVKPISIPVDAETNRLIFANELDEVEAIYWQASLGYLGNRL 672

Human   552 FSYGQ--PLILTFRVPPGD---SPL--PVQLRLEGTGLALSLRHSSLSGPQDAGHPREVELR--- 606
            .|||.  .|:|::.|..||   .|.  |..:.:...||.::....||.|   .|....|.|.   
  Fly   673 TSYGSRLQLVLSWDVIRGDRSGKPTTGPNVILVGKNGLKIAFGDESLDG---LGINLNVTLTEVG 734

Human   607 -FHLQETSEDVAPPL-----PPFH--------FQRLLANLTSLRLRVSPGPSPAGPVFLTEVRLT 657
             :|:..|..|:...|     ..:|        |..:|.:|.::.:|.:         |.|:...|
  Fly   735 WYHVPPTVVDIKTRLRRTEGGDYHGESVTRSQFLSVLVSLDAVLIRAA---------FHTDQGET 790

Human   658 SARPGL---------SPPASWVEICSCPTGYTGQFCESCAPGYKREMPQGGPY---ASCVPCTCN 710
            |....:         ...:|.||.|.||.||||..||.||.|:||.......:   :.|:||.||
  Fly   791 SLERAVIYSGGVELGGKSSSQVEQCLCPAGYTGLSCEGCAFGFKRIYENTSDHQILSKCIPCPCN 855

Human   711 QH-GTCDPNTGIC-VCSHHTEGPSCERCLPGFYGNPFAGQADDCQPCPCP-------GQSACT-- 764
            .| .:||..:|.| .|.|:|.|..||||..|:||||..|..:||:.|.||       ...:|.  
  Fly   856 GHSNSCDLQSGNCGDCMHNTFGDRCERCQLGYYGNPLQGTPNDCKRCACPLSEDSNNFSPSCQLK 920

Human   765 -----------TIPESREVVCTHCPPGQRGRRCEVCDDGFFGDPLGLFGHPQP---CHQCQCSGN 815
                       .:.|..|.:||.||.|..|..|:|||||:||:|      .||   |.:|.|:| 
  Fly   921 SYNYMDLNPQFELIEHAEYICTQCPEGYTGDHCQVCDDGYFGNP------RQPGSSCQRCDCAG- 978

Human   816 VDPNAVGNCDPLSGHCLRCLHNTTGDHCEHCQEGFYGSALAPRPADKCMPCSCHPQGSVS----- 875
                  |.|:..:|.|:.|..||.|.|||.|:.|::|.     ||..|.||.||.:||.|     
  Fly   979 ------GPCNVTTGECITCRGNTEGWHCERCKLGYWGD-----PAVGCDPCHCHTEGSESGLCDS 1032

Human   876 ----------------------------------------------------------------- 875
                                                                             
  Fly  1033 TDGQCLCKPRYAGQKCDECDVGYANVELRCPSCNCDPLGSLVQDRCDPHTGQCHCKEGVMGAKCH 1097

Human   876 ---------------------------------EQMP---------------------------C 880
                                             |.:|                           |
  Fly  1098 ECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDTEDPNSESTVACEECHCSSVGSLSSDC 1162

Human   881 DPVTGQCSCLPHVTARDCSRCYPGFFDLQPGRGCRSCKCHPLGSQEDQCHPKTGQCTCRPGVTGQ 945
            |..||||:||.:||.|.|.:|.||.::|..|.|||.|:|.|.||:..:|:|.||||.|:.||.||
  Fly  1163 DKRTGQCACLANVTGRRCDKCRPGHWNLTAGEGCRDCRCDPHGSRGHECNPWTGQCDCKIGVGGQ 1227

Human   946 ACDRCQLGFFGFSIK-----------------------------------------------GCR 963
            .|:.|..||||||.:                                               |||
  Fly  1228 HCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWGWQARLGCR 1292

Human   964 ACRCSPLGAASAQCHE-NGTCVCRPGFEGYKCDRCHDNFF---------LTADGTHCQ------- 1011
            .|.|..:|:...||.. :|.|.||.|:.|.|||.|...:|         ..|:|:..|       
  Fly  1293 ECECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFGYPECRRCGCDAEGSFTQADGSIAC 1357

Human  1012 ----QCPSCYALVKEEAAKLKARLTLTEGWLQGSDCGSPWGPLDILL----GEAPRGDVYQGHHL 1068
                ||| |.:||    ..||....:...:  |....:|.|......    ||..:.|:..||..
  Fly  1358 DSNGQCP-CKSLV----VGLKCDTCMQSTF--GLSAQNPEGCTRCFCFGRSGECEQSDLSWGHIR 1415

Human  1069 LPGAREAFLEQ---------------MMSLEGAVKAARE--QLQRLN 1098
            :..:|...::|               ::.:||: ...||  ::||:|
  Fly  1416 MAESRNLSVQQIRPHSVPSSDYEYIVVVQMEGS-SFHREDAEIQRMN 1461

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LAMC3XP_011516423.1 Laminin_N 44..269 CDD:278484 72/258 (28%)
EGF_Lam 270..317 CDD:238012 25/48 (52%)
Laminin_EGF 327..383 CDD:278482 22/58 (38%)
EGF_Lam 382..428 CDD:238012 14/45 (31%)
Laminin_EGF 430..477 CDD:278482 21/46 (46%)
Laminin_B 541..662 CDD:278481 34/144 (24%)
EGF_Lam 706..753 CDD:238012 24/48 (50%)
EGF_Lam 754..802 CDD:238012 21/67 (31%)
Laminin_EGF 810..857 CDD:278482 17/46 (37%)
EGF_Lam 865..915 CDD:238012 27/179 (15%)
Laminin_EGF 917..965 CDD:278482 27/94 (29%)
EGF_Lam 964..1011 CDD:238012 18/56 (32%)
PspA_IM30 1191..1426 CDD:281941
ATP-synt_B <1360..1453 CDD:304375
wbNP_723870.1 Laminin_N 164..396 CDD:278484 69/242 (29%)
EGF_Lam 401..450 CDD:238012 26/54 (48%)
TNFRSF <407..507 CDD:304602 45/110 (41%)
EGF_Lam 505..552 CDD:238012 16/49 (33%)
Laminin_EGF 550..597 CDD:278482 21/46 (46%)
Laminin_B 660..798 CDD:278481 34/149 (23%)
EGF_Lam 851..900 CDD:238012 24/48 (50%)
Laminin_EGF <943..971 CDD:278482 15/33 (45%)
VSP 953..1414 CDD:146106 122/485 (25%)
Laminin_EGF 974..1018 CDD:278482 20/55 (36%)
EGF_Lam 1017..1065 CDD:238012 7/47 (15%)
Laminin_EGF 1065..>1105 CDD:278482 0/39 (0%)
EGF_Lam 1150..1197 CDD:238012 18/46 (39%)
Laminin_EGF 1199..1247 CDD:278482 24/47 (51%)
EGF_Lam 1247..1292 CDD:238012 1/44 (2%)
Laminin_EGF 1294..1342 CDD:278482 16/47 (34%)
Laminin_EGF 1340..1392 CDD:278482 13/58 (22%)
Laminin_B 1486..1611 CDD:278481
EGF_Lam 1669..1716 CDD:238012
Laminin_EGF 1718..1767 CDD:278482
EGF_Lam 1772..1819 CDD:238012
CrfC <1933..2267 CDD:223771
Laminin_II 2277..2400 CDD:283628
LamG 2399..>2492 CDD:304605
Laminin_G_2 2616..2755 CDD:280389
Laminin_G_2 2804..2944 CDD:280389
Laminin_G_2 3038..3169 CDD:280389
LamG 3192..3347 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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