Protein Alignment NMUR1 and Nmur1

DIOPT Version :10

• Sequence 1: NP_006047.3
• Gene: NMUR1 / 10316
• HGNCID: 4518
• Length: 426
• Species: Homo sapiens
• Sequence 2: XP_017452122.1
• Gene: Nmur1 / 65276
• RGDID: 619867
• Length: 414
• Species: Rattus norvegicus
• Alignment Length: 412
• Identity: 293/412 - (71%)
• Similarity: 328/412 - (79%)
• Gaps: 4/412 - (0%)

Human    15 LYPGGARNPMACNGSAARGHFDPEDLNLTDEALRLKYLGPQQTELFMPICATYLLIFVVGAVGNG 79
            |.|..:...::||.|..:.|||.||||||.|.||||||||||.:.|:|||.|||||||||.:|||
  Rat     4 LSPNASTGLLSCNDSEFKEHFDLEDLNLTHEDLRLKYLGPQQVKQFLPICVTYLLIFVVGTLGNG 68

Human    80 LTCLVILRHKAMRTPTNYYLFSLAVSDLLVLLVGLPLELYEMWHNYPFLLGVGGCYFRTLLFEMV 144
            |||.||||.|||.||||:||||||||||||||||||||||||.|||||.||.||||||.||.|.|
  Rat    69 LTCTVILRQKAMHTPTNFYLFSLAVSDLLVLLVGLPLELYEMQHNYPFQLGAGGCYFRILLLETV 133

Human   145 CLASVLNVTALSVERYVAVVHPLQARSMVTRAHVRRVLGAVWGLAMLCSLPNTSLHGIRQLHVPC 209
            |||||||||||||||||||||||||:|::||.||||:|||:|..|:|.|||||||||:..|:|||
  Rat   134 CLASVLNVTALSVERYVAVVHPLQAKSVMTRTHVRRMLGAIWVFAILFSLPNTSLHGLSPLYVPC 198

Human   210 RGPVPDSAVCMLVRPRALYNMVVQTTALLFFCLPMAIMSVLYLLIGLRLRRERLLLMQEAKGRGS 274
            |||||||..|.||||:..|.:|:|||.||||||||..:|||||||||||||||:||.:|.|||.|
  Rat   199 RGPVPDSVTCTLVRPQFFYKLVIQTTILLFFCLPMVTISVLYLLIGLRLRRERILLQEEVKGRIS 263

Human   275 AAARSRYTCRLQQHDRGRRQVTKMLFVLVVVFGICWAPFHADRVMWSVVSQWTDGLHLAFQHVHV 339
            ||||......:|..||.||||||||..||:|||.||.||||||:|||:||.|||||.||||.||:
  Rat   264 AAARQASHRSIQLRDRERRQVTKMLIALVIVFGTCWVPFHADRLMWSMVSHWTDGLRLAFQSVHL 328

Human   340 ISGIFFYLGSAANPVLYSLMSSRFRETFQEALCLGA-CCHRLRPRHSSHSLSRMTTGSTLCDVGS 403
            .||:|.|||||||||||:|||:||||:|:|.|.||. ||||.:|||.|||..|:||.|||||..|
  Rat   329 ASGVFLYLGSAANPVLYNLMSTRFRESFRETLGLGTRCCHRHQPRHDSHSHLRLTTVSTLCDRNS 393

Human   404 LGSWVHPLAGNDGPEAQQETDP 425
            ...   |||.|..|..:|||||
  Rat   394 RDV---PLAENRDPGCEQETDP 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NMUR1	NP_006047.3	7tmA_NMU-R1	61..367	CDD:320480	233/305 (76%)
		TM helix 1	61..88	CDD:320480	21/26 (81%)
		TM helix 2	95..121	CDD:320480	24/25 (96%)
		TM helix 3	134..164	CDD:320480	26/29 (90%)
		TM helix 4	176..198	CDD:320480	14/21 (67%)
		TM helix 5	228..257	CDD:320480	21/28 (75%)
		TM helix 6	290..320	CDD:320480	22/29 (76%)
		TM helix 7	335..360	CDD:320480	18/24 (75%)
Nmur1	XP_017452122.1	7tm_GPCRs	50..356	CDD:475119	233/305 (76%)
		TM helix 1	52..76	CDD:410628	19/23 (83%)
		TM helix 2	85..107	CDD:410628	20/21 (95%)
		TM helix 3	124..146	CDD:410628	18/21 (86%)
		TM helix 4	169..185	CDD:410628	9/15 (60%)
		TM helix 5	218..241	CDD:410628	15/22 (68%)
		TM helix 6	285..307	CDD:410628	16/21 (76%)
		TM helix 7	324..349	CDD:410628	18/24 (75%)