Protein Alignment NMUR1 and nmur-2

DIOPT Version :10

• Sequence 1: NP_006047.3
• Gene: NMUR1 / 10316
• HGNCID: 4518
• Length: 426
• Species: Homo sapiens
• Sequence 2: NP_493666.2
• Gene: nmur-2 / 173398
• WormBaseID: WBGene00019616
• Length: 403
• Species: Caenorhabditis elegans
• Alignment Length: 406
• Identity: 120/406 - (29%)
• Similarity: 189/406 - (46%)
• Gaps: 85/406 - (20%)

Human    49 LKYLGP--QQTELFMPICATYLLIFVVGAVGNGLTCLVILRHKAMRTPTNYYLFSLAVSDLLVLL 111
            |..||.  |...:.:|....|..||::|..||..||:||..:|:|..|||||||||||||::.|:
 Worm    18 LSTLGERCQSAGIVIPTVIIYGTIFLLGLFGNICTCIVIAANKSMHNPTNYYLFSLAVSDIIALI 82

Human   112 VGLPLELYE-MWHNYPFLLGVGGCYFRTLLFEMVCLASVLNVTALSVERYVAVVHPLQAR--SMV 173
            :|||:|.|: :.::||:....|.|..|..|.|....||::.:...|.||::|:.|||:::  |.:
 Worm    83 LGLPMEFYQSLDYSYPYRFSEGICKARAFLIEFTSYASIMIICCFSFERWLAICHPLRSKIFSTL 147

Human   174 TRAHVRRVLGAVWGLAMLCSLPNTSLHGIRQLHVPCRGPVPDSA--------------------V 218
            .||:|..:|  .|.::.:|:||...:..|.:|      |:|:.|                    .
 Worm   148 WRANVLIIL--AWTISFVCALPIAFIVQINKL------PLPEDAKYQPWTNKVSTDGIFVLHTEF 204

Human   219 CMLVRPRA-LYNMVVQTTALLFFCLPMAIMSVLYLLIGLRLRRERLLLMQEAKGRGSAAARSRYT 282
            |.:.:.|. ...|::.....:||.:|...:.::|..|.::|....:.|      :|....:.|
 Worm   205 CAMNQSRPDQQKMIIIFAFTVFFVIPAIAIVIMYAHIAVQLESSEIDL------KGDKMVKKR-- 261

Human   283 CRLQQHDRGRRQVTKMLFVLVVVFGICWAPFHADRVMWSVVSQWTD------GLHLAFQHVHVIS 341
                 .::..|.|.|||..:|:.|.|||.|||..|:: ||.:.|::      .:......|..||
 Worm   262 -----RNKSNRTVLKMLLSVVITFFICWLPFHIQRLL-SVYTTWSETTTISPPVQFLSMIVFYIS 320

Human   342 GIFFYLGSAANPVLYSLMSSRFRETFQEALCLGACCHRL--------------RPRHSSHSLSR- 391
            |..:|..|||||:||:::|.::|..|         |..:              ||..|....|.
 Worm   321 GFCYYSNSAANPILYNILSQKYRSAF---------CRTILGDHIANFVFKGHQRPGQSKRCSSST 376

Human   392 -------MTTGSTLCD 400
                   ||.||...|
 Worm   377 EAEQRTLMTRGSVRVD 392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NMUR1	NP_006047.3	7tmA_NMU-R1	61..367	CDD:320480	105/335 (31%)
		TM helix 1	61..88	CDD:320480	11/26 (42%)
		TM helix 2	95..121	CDD:320480	18/26 (69%)
		TM helix 3	134..164	CDD:320480	10/29 (34%)
		TM helix 4	176..198	CDD:320480	7/21 (33%)
		TM helix 5	228..257	CDD:320480	6/28 (21%)
		TM helix 6	290..320	CDD:320480	14/29 (48%)
		TM helix 7	335..360	CDD:320480	12/24 (50%)
nmur-2	NP_493666.2	7tmA_capaR	32..346	CDD:320262	105/335 (31%)
		TM helix 1	32..59	CDD:320262	11/26 (42%)
		TM helix 2	66..92	CDD:320262	18/25 (72%)
		TM helix 3	106..136	CDD:320262	10/29 (34%)
		TM helix 4	148..170	CDD:320262	8/23 (35%)
		TM helix 5	215..244	CDD:320262	6/28 (21%)
		TM helix 6	264..294	CDD:320262	14/30 (47%)
		TM helix 7	314..339	CDD:320262	12/24 (50%)