Protein Alignment TCIRG1 and Vha100-2

DIOPT Version :10

• Sequence 1: NP_006010.2
• Gene: TCIRG1 / 10312
• HGNCID: 11647
• Length: 830
• Species: Homo sapiens
• Sequence 2: NP_650722.1
• Gene: Vha100-2 / 42216
• FlyBaseID: FBgn0028670
• Length: 834
• Species: Drosophila melanogaster
• Alignment Length: 871
• Identity: 371/871 - (42%)
• Similarity: 518/871 - (59%)
• Gaps: 83/871 - (9%)

Human     1 MGSMFRSEEVALVQLFLPTAAAYTCVSRLGELGLVEFRDLNASVSAFQRRFVVDVRRCEELEKTF 65
            ||.||||||:||.|:|:...||||.||.|||.|.|:|||||.:|:||||:||.:||||:|||:..
  Fly     1 MGDMFRSEEMALCQMFIQPEAAYTSVSELGETGCVQFRDLNVNVNAFQRKFVTEVRRCDELERKI 65

Human    66 TFLQEEVRRAGLVLPPPKGRLP-APPPRDLLRIQ---EETE----RLAQ-------------ELR 109
            .:::.|:::.|:|||..:..:| ||.||:::.::   |:||    .|||             |||
  Fly    66 RYIETEIKKDGIVLPDIQDDIPRAPNPREIIDLEAHLEKTESEMIELAQNEVNMKSNYLELTELR 130

Human   110 DVRGNQQALRAQLHQLQLHAAVLRQGHEPQLAAAHTDGASERTPLLQAPGGPHQDLRVNFVAGAV 174
            .|..|.|...:....|.|.:: .|.|.:...||.|..                   |:.||||.:
  Fly   131 KVLENTQGFFSDQEVLNLDSS-NRAGGDNDAAAQHRG-------------------RLGFVAGVI 175

Human   175 EPHKAPALERLLWRACRGFLIASFRELEQPLEHPVTGEPATWMTFLISYWGEQIGQKIRKITDCF 239
            ...:..|.||:|||..||.:.....:|::||..|.||.|.....|:..:.|||:..:|:|:...|
  Fly   176 NRERVFAFERMLWRISRGNVFLKRSDLDEPLNDPATGHPIYKTVFVAFFQGEQLKNRIKKVCTGF 240

Human   240 HCHVFPFLQQEEARLGALQQLQQQSQELQEVLGETERFLSQVLGRVLQLLPPGQVQVHKMKAVYL 304
            |..::|.......|...::.::.:.::|:.||.:||...|:||..|.:.||...:.|.||||:|.
  Fly   241 HASLYPCPSSHNEREEMVRNVRTRLEDLKLVLSQTEDHRSRVLATVSKNLPSWSIMVKKMKAIYH 305

Human   305 ALNQCSVSTTHKCLIAEAWCSVRDLPALQEALRDSSMEEG--VSAVAHRIPCRDMPPTLIRTNRF 367
            .||..::..|.||||.|.|....|||.:|:||.|.|...|  :.:..:.|...:.|||..|||:|
  Fly   306 TLNLFNMDVTKKCLIGECWVPTNDLPVVQKALSDGSAAVGSTIPSFLNVIDTNEQPPTFNRTNKF 370

Human   368 TASFQGIVDAYGVGRYQEVNPAPYTIITFPFLFAVMFGDVGHGLLMFLFALAMVLAENRPAVKAA 432
            |..||.::|||||..|:|.|||.||.|||||||||||||:||||::.||...|||.|.:.|....
  Fly   371 TRGFQNLIDAYGVASYRECNPALYTCITFPFLFAVMFGDLGHGLILVLFGAWMVLCERKLARIRN 435

Human   433 QNEIWQTFFRGRYLLLLMGLFSIYTGFIYNECFSRATSIFPSGWSVAAMANQSGWSDAFLAQHTM 497
            ..|||..||.|||::||||||::|||.:||:.||::.::|.|.|.       :.::...:..:..
  Fly   436 GGEIWNIFFGGRYIILLMGLFAMYTGLVYNDVFSKSMNLFGSRWF-------NNYNTTTVLTNPN 493

Human   498 LTLDPNVTGVFLGPYPFGIDPIWSLAANHLSFLNSFKMKMSVILGVVHMAFGVVLGVFNHVHFGQ 562
            |.|.||.:.|  |.||||:||:|.||.|.:.||||||||:|:|.||:||.|||.:.|.|..||.:
  Fly   494 LQLPPNSSAV--GVYPFGMDPVWQLADNKIIFLNSFKMKLSIIFGVLHMVFGVCMSVVNFTHFKR 556

Human   563 RHRLLLETLPELTFLLGLFGYLVFLVIYKWLCVWAARAA-------SAPSILIHFINMFLFSHSP 620
            ...:.||.:|::.|||.||||:||::.:||.. :.||.:       .|||:||.||||.||.::.
  Fly   557 YASIFLEFVPQILFLLLLFGYMVFMMFFKWFS-YNARTSFQPETPGCAPSVLIMFINMMLFKNTE 620

Human   621 ----SNRLLYPRQEVVQATLVVLALAMVPILLLGTPLHLLHRHRRRLRRRPADRQEENK-AGLLD 680
                .|..::..|..:|...|::||..:|.:|||.||::     :..|:..|......: .|.::
  Fly   621 PPKGCNEFMFESQPQLQKAFVLIALCCIPWMLLGKPLYI-----KFTRKNKAHANHNGQLTGNIE 680

Human   681 LPDASV---NGWSSDEEKAGGLDDEEEAELVPSEVLMHQAIHTIEFCLGCVSNTASYLRLWALSL 742
            |.:...   .|:|.:||.|||....::..:  ||:.:||||||||:.|..:|:||||||||||||
  Fly   681 LAEGETPLPTGFSGNEENAGGAHGHDDEPM--SEIYIHQAIHTIEYVLSTISHTASYLRLWALSL 743

Human   743 AHAQLSEVLWAMVMRIGL---GLGREVGVAAVVLVPIFAAFAVMTVAILLVMEGLSAFLHALRLH 804
            ||||||||||.||:.:||   |:|..:|     |..||.|:.:.|:|||::|||||||||.||||
  Fly   744 AHAQLSEVLWQMVLSLGLKMSGVGGAIG-----LFIIFGAWCLFTLAILVLMEGLSAFLHTLRLH 803

Human   805 WVEFQNKFYSGTGYKLSPFTFAATDD 830
            ||||.:|||.|.||...||:|.|..|
  Fly   804 WVEFMSKFYEGMGYAFQPFSFKAILD 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TCIRG1	NP_006010.2	V_ATPase_I	27..825	CDD:460232	351/838 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	139..158		3/18 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	681..701		8/22 (36%)
Vha100-2	NP_650722.1	V_ATPase_I	27..824	CDD:460232	351/838 (42%)