Protein Alignment TCIRG1 and Vha100-4

DIOPT Version :10

• Sequence 1: NP_006010.2
• Gene: TCIRG1 / 10312
• HGNCID: 11647
• Length: 830
• Species: Homo sapiens
• Sequence 2: NP_650720.1
• Gene: Vha100-4 / 42214
• FlyBaseID: FBgn0038613
• Length: 844
• Species: Drosophila melanogaster
• Alignment Length: 854
• Identity: 336/854 - (39%)
• Similarity: 499/854 - (58%)
• Gaps: 65/854 - (7%)

Human     3 SMFRSEEVALVQLFLPTAAAYTCVSRLGELGLVEFRDLNASVSAFQRRFVVDVRRCEELEKTFTF 67
            |:||||.::|||::|...|||..::.|||:|.|:||||||.::|.||:|:.:||||:|||:...:
  Fly    15 SIFRSEVMSLVQMYLQPEAAYDTIAALGEVGCVQFRDLNAKINAQQRKFIGEVRRCDELERRIRY 79

Human    68 LQEEVRRAG-LVLPPPKGRLPAPPPRDLLRIQEETERLAQELRDVRGNQQALRAQLHQLQLHAAV 131
            :..|:.:.| .||.......|||.||:::.::...|:...|:.::..|...|:....:|.....|
  Fly    80 VTAELNKEGHKVLDLMDDFPPAPQPREIIDLELHLEKTETEILELAANNVNLQTSYLELSEMIQV 144

Human   132 LRQGHEPQLAAAHTDGASERTPLLQAPGGPHQDL-----RVNFVAGAVEPHKAPALERLLWRACR 191
            |.:..:     ..:|..|....|.:.  |.|:|.     .:.||||.:...:..|.||:|||..|
  Fly   145 LERTDQ-----FFSDQESHNFDLNKM--GTHRDPEKSNGHLGFVAGVISREREYAFERMLWRISR 202

Human   192 GFLIASFRELEQPLEHPVTGEPATWMTFLISYWGEQIGQKIRKITDCFHCHVFPFLQQEEARLGA 256
            |.:.....:::..|..|.||.......|::.:.|:|:..:|||:...||.|::|.......|...
  Fly   203 GNVFVRRCDVDVALTDPKTGNVLHKSVFVVFFQGDQLQARIRKVCTGFHAHMYPCPSSHSERQEM 267

Human   257 LQQLQQQSQELQEVLGETERFLSQVLGRVLQLLPPGQVQVHKMKAVYLALNQCSVSTTHKCLIAE 321
            ::.::.:.::||.::.:|....:.||...|:.||.....|.|||.:|..||..:|....||||.|
  Fly   268 VKNVRTRLEDLQVIINQTSDHRTCVLQAALKQLPTWSAMVKKMKGIYHTLNLFNVDLGSKCLIGE 332

Human   322 AWCSVRDLPALQEALRDSSMEEG--VSAVAHRIPCRDMPPTLIRTNRFTASFQGIVDAYGVGRYQ 384
            .|...|:|..::.||...|...|  |.:..:.:..:..|||..|||:||..||.::||||:..|:
  Fly   333 GWVPKRELELVEVALAAGSASVGSTVPSFINVLDTKKEPPTHFRTNKFTRGFQNLIDAYGIAGYR 397

Human   385 EVNPAPYTIITFPFLFAVMFGDVGHGLLMFLFALAMVLAENRPAVKAAQNEIWQTFFRGRYLLLL 449
            ||||..||.|||||||||||||:|||.::||..|.||:.|.|.:.|.. .|||..||.|||:::|
  Fly   398 EVNPGLYTCITFPFLFAVMFGDMGHGTILFLLGLWMVIDEKRLSKKRG-GEIWNIFFAGRYIIML 461

Human   450 MGLFSIYTGFIYNECFSRATSIFPSGWSVAAMANQSGWSDAFLAQHTMLTLDPNVTGVFLGPYPF 514
            ||||::||||.||:.||::.::|.:.|       .:.::...:..:..|.|:|:|  ...|.||.
  Fly   462 MGLFAMYTGFHYNDIFSKSINVFGTRW-------VNVYNRTTVLTNPTLQLNPSV--ATRGVYPM 517

Human   515 GIDPIWSLAANHLSFLNSFKMKMSVILGVVHMAFGVVLGVFNHVHFGQRHRLLLETLPELTFLLG 579
            ||||||..|:|.:.|||::|||:|:|.||:||.|||.:.|.|.|.|.:...::|:.:|::.|||.
  Fly   518 GIDPIWQSASNKIIFLNTYKMKLSIIFGVLHMVFGVCMSVENFVFFKKYAYIILQFVPQVLFLLL 582

Human   580 LFGYLVFLVIYKWL------CVWAARAASAPSILIHFINMFLFSHSPS----NRLLYPRQEVVQA 634
            :|||:.|::.|||:      .|.|.....|||:||.||:|.||....:    :..::|.|:.::.
  Fly   583 MFGYMCFMMFYKWVKYSPTTDVEADTPGCAPSVLIMFIDMVLFKTETALPGCDVNMFPIQKNLEM 647

Human   635 TLVVLALAMVPILLLGTPLHLLHRHRRRLRRRPADRQEE-------------NKAGLLDLPDASV 686
            ..:|:||..:|.:|||.||::.::.    |.|||...||             .:..:.::.:|..
  Fly   648 IFLVVALLCIPWILLGKPLYIKYQR----RNRPAGPVEEVDEIVEKIEVTTGKEIIITEVAEAHE 708

Human   687 NGWSSDEEKAGGLDDEEEAELVPSEVLMHQAIHTIEFCLGCVSNTASYLRLWALSLAHAQLSEVL 751
            :|..|:|      |||.     .||:.:||||||||:.|..:|:|||||||||||||||||||||
  Fly   709 SGGHSEE------DDEP-----MSEIWIHQAIHTIEYILSTISHTASYLRLWALSLAHAQLSEVL 762

Human   752 WAMVMRIGLGLGREVGVAAVVLVPIFAAFAVMTVAILLVMEGLSAFLHALRLHWVEFQNKFYSGT 816
            |.||:.:||.:...||  |:.|..|||.:...|:||:::|||||||||.||||||||.:|||.|.
  Fly   763 WTMVLAMGLQMNGYVG--AIGLFFIFAVWEFFTIAIMVMMEGLSAFLHTLRLHWVEFMSKFYVGN 825

Human   817 GYKLSPFTF 825
            ||..:||:|
  Fly   826 GYPFTPFSF 834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TCIRG1	NP_006010.2	V_ATPase_I	27..825	CDD:460232	323/828 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	139..158		3/18 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	681..701		4/19 (21%)
Vha100-4	NP_650720.1	V_ATPase_I	39..834	CDD:460232	323/828 (39%)