Protein Alignment TCIRG1 and Vha100-5

DIOPT Version :10

• Sequence 1: NP_006010.2
• Gene: TCIRG1 / 10312
• HGNCID: 11647
• Length: 830
• Species: Homo sapiens
• Sequence 2: NP_609515.1
• Gene: Vha100-5 / 34587
• FlyBaseID: FBgn0032373
• Length: 814
• Species: Drosophila melanogaster
• Alignment Length: 858
• Identity: 336/858 - (39%)
• Similarity: 497/858 - (57%)
• Gaps: 87/858 - (10%)

Human     1 MGSMFRSEEVALVQLFLPTAAAYTCVSRLGELGLVEFRDLNASVSAFQRRFVVDVRRCEELEKTF 65
            ||.|||||::||.|||:...|||..::.|||.|.|:|||||..||||||::|.:||||:::|:..
  Fly     1 MGDMFRSEKMALCQLFIQPEAAYASIAELGEKGCVQFRDLNEEVSAFQRKYVNEVRRCDDMERRL 65

Human    66 TFLQEEVRRAGLVLP--PPKGRLPAPPPRDLLRIQEETERLAQELRDVRGNQQALRAQLHQLQLH 128
            .:::.|:::..:.||  .|:....||.||:::.::.:.|:...|||::..|..:|.|....:|..
  Fly    66 RYVESEMKKDEVKLPVLRPEEEPIAPNPREIVDLEAQLEKTDNELREMSANGASLDANFRHMQEL 130

Human   129 AAVLRQGH-----------------EPQLAAAHTDGASERTPLLQAPGGPHQDLRVNFVAGAVEP 176
            ..||....                 :|: ..|:..||::|..|.             ||||.::.
  Fly   131 KYVLENTEGFFSDQEVINLDVNRKLDPE-DPANLPGAAQRGQLA-------------FVAGVIKL 181

Human   177 HKAPALERLLWRACRGFLIASFRELEQPLEHPVTGEPATWMTFLISYWGEQIGQKIRKITDCFHC 241
            .:..:.||:|||..||.:.....:::..:....||.|.....|:..:.|||:.|:|:|:...:|.
  Fly   182 ERFFSFERMLWRISRGNIFLRRADIDGLVADEETGRPVLKTVFVAFFQGEQLKQRIKKVCTGYHA 246

Human   242 HVFPFLQQEEARLGALQQLQQQSQELQEVLGETERFLSQVLGRVLQLLPPGQVQVHKMKAVYLAL 306
            .|:|.......|...::.:..:.::|:.||.::....|:||....:.||...:.|.||||:|..|
  Fly   247 AVYPCPSSHAERKEMIKDVNVRLEDLKLVLSQSADHRSRVLNSASKHLPRWSIMVRKMKAIYHIL 311

Human   307 NQCSVSTTHKCLIAEAWCSVRDLPALQEALRDSS--MEEGVSAVAHRIPCRDMPPTLIRTNRFTA 369
            |..:...|.||||.|.|....|:..:|:||..:|  .|..:.|..:.|...:||||..|||:||.
  Fly   312 NFFNPDVTGKCLIGEGWVPTNDISTVQDALARASKISESSIPAFMNVIETNEMPPTYTRTNKFTN 376

Human   370 SFQGIVDAYGVGRYQEVNPAPYTIITFPFLFAVMFGDVGHGLLMFLFALAMVLAENRPAVKAAQN 434
            .||.:||:||:..|:|||||.|..|||||||||||||:||||::.|||..:::.|.:  :.:.:.
  Fly   377 GFQNLVDSYGMASYREVNPALYACITFPFLFAVMFGDLGHGLILLLFASWLIIKEKQ--LSSIKE 439

Human   435 EIWQTFFRGRYLLLLMGLFSIYTGFIYNECFSRATSIFPSGWSVAAMANQSGWSDAFLAQHTM-- 497
            ||:..||.|||::.|||:||||||||||:.||::.:||.|.|.:       .::...:....:
  Fly   440 EIFNIFFGGRYIIFLMGIFSIYTGFIYNDVFSKSMNIFGSAWHM-------NYTRDVVEDENLKY 497

Human   498 LTLDPNVTGVFLGPYPFGIDPIWSLAANHLSFLNSFKMKMSVILGVVHMAFGVVLGVFNHVHFGQ 562
            :||.||.|  ....||||:||||.||.|.:.|||:||||:|:|:||:||.|||.:.|.|..::.:
  Fly   498 ITLRPNDT--VYKTYPFGMDPIWQLADNKIIFLNTFKMKLSIIVGVIHMIFGVSMSVVNFAYYKK 560

Human   563 RHRLLLETLPELTFLLGLFGYLVFLVIYKWLCV-----WAARAASAPSILIHFINMFL----FSH 618
            ...:.||.||::.|||.||||:||::.:||:..     .....|.||||||.||||.|    .:.
  Fly   561 YASIFLEFLPQVLFLLLLFGYMVFMMFFKWVVYNDTVEGPLSPACAPSILILFINMILQGSQDTP 625

Human   619 SPSNRLLYPRQEVVQATLVVLALAMVPILLLGTPLHLLHRHRRRLRRRPADRQEENKAGLLDLPD 683
            .|....::..|:.:|...||:|:..:|.:|||.||:::      ::|:
  Fly   626 EPCKEFMFDGQKSIQQVFVVVAIICIPWMLLGKPLYIM------IKRK----------------- 667

Human   684 ASVNGWSSDEEKAGGLDDE-EEAELVPSEVLMHQAIHTIEFCLGCVSNTASYLRLWALSLAHAQL 747
              .||....:.::||.:.. |:.|:  .|:.:||||||||:.|..||:|||||||||||||||||
  Fly   668 --TNGAPPPKPQSGGGEGHGEDDEM--GEIFIHQAIHTIEYVLSTVSHTASYLRLWALSLAHAQL 728

Human   748 SEVLWAMVMRIGLGLGREVGVAAVVLVPIFAAFAVMTVAILLVMEGLSAFLHALRLHWVEFQNKF 812
            |||||.||..:|......:|  .:::...|.|:|::||.||:::||||||||.||||||||.:||
  Fly   729 SEVLWNMVFSMGFKYDSYIG--GILIYVFFGAWALLTVGILVLIEGLSAFLHTLRLHWVEFMSKF 791

Human   813 YSGTGYKLSPFTF 825
            |.|.||...||.|
  Fly   792 YEGAGYAFEPFAF 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TCIRG1	NP_006010.2	V_ATPase_I	27..825	CDD:460232	320/830 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	139..158		5/18 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	681..701		4/19 (21%)
Vha100-5	NP_609515.1	V_ATPase_I	27..804	CDD:460232	320/830 (39%)