DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TCIRG1 and Vha100-3

DIOPT Version :9

Sequence 1:	XP_024304088.1	Gene:	TCIRG1 / 10312	HGNCID:	11647	Length:	861	Species:	Homo sapiens
Sequence 2:	NP_725837.1	Gene:	Vha100-3 / 246543	FlyBaseID:	FBgn0028669	Length:	904	Species:	Drosophila melanogaster

Alignment Length:	977	Identity:	260/977 - (26%)
Similarity:	402/977 - (41%)	Gaps:	207/977 - (21%)

- Green bases have known domain annotations that are detailed below.

Human     3 SMFRSEEVALVQLFLPTAAAYTCVSRLGELGLVEFRDLNASVSAFQRRFVVDVRRCEELEKTFTF 67
            |.||||::.|.||.|.|..|:.|:..:|..|.|:|.::..........:...|.:|.||.:....
  Fly    13 SFFRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYELLRIVDS 77

Human    68 LQEEVRRAGL--VLPPPKGRLPAPPPRDLLRIQEETERLAQELRDVRGNQQALRAQLHQLQLHAA 130
            |...:.:..:  :..|...|......:||.:..:..:|:..|...|..:...|.::.:::..|:.
  Fly    78 LHTYIVQLHVNEIFYPDVDRENRLKEKDLAKYSDSLKRIHVEASAVTEHYYRLDSRRNRMMEHSF 142

Human   131 VLRQGHEPQLAAAHTDGASERTPLLQAPG---GPHQD---------LRVNFVAGAVEPHKAPALE 183
            .|.:.::..:    :|..||   ||.:..   |..||         ..:|::.|.:...|..:.|
  Fly   143 ALNKANKYMV----SDMGSE---LLYSESTVIGLVQDATTTSGAYPAHLNYMIGCIRADKFYSFE 200

Human   184 RLLWRACRGFLIASFRELEQPL-EHPVTGEPATWMTFLISYWGE--QIGQKIRKIT--------D 237
            .||:|.|...||..|.|:..|: |:....:|.....|.|.....  .|..|:.||.        |
  Fly   201 LLLYRLCSFNLIIRFSEMPSPVYEYHYGYKPERVRKFAILMMASSTMIWPKVLKICAHYHVNIYD 265

Human   238 CASSL----------------------QLPLPRLPVSAAGGGPPRGPAAAATAEPGAAGGPRGDR 280
            |.||.                      :..|.|..:....|                     .|.
  Fly   266 CPSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILEVAG---------------------RDL 309

Human   281 AVPEPGARPGAAAAAARAGAGPQDEGRVPGPEPVQREHHAQ-------VPHCRGLVLCARPARPA 338
            .:.....|........      .:..|:.|...|.|...|:       ||...  |:....:|.:
  Fly   310 FIIRVNLRKALKVYDL------MNRLRLVGGVEVPRYLLAEVYIPSSDVPEVE--VILRNASRIS 366

Human   339 GGPAGQLDGGGSECRGSPHPLPGHAPH--THPHQPLHGQLPGHRGCLRRGPLPGGQPRSLHHHHL 401
            || |..:|....:.......:|...|:  ....|||.....| ...|::..|.         :|:
  Fly   367 GG-ADNIDSSDEDEMNDMKTMPNTTPYPIEADFQPLEDMSAG-AILLKKNRLV---------NHM 420

Human   402 PLPVCCDVRGCGPRAAHVPVRPGHGPCGEPT---------GCEGRAER-DLADFLQ-GPLP---- 451
            |                            ||         |.:...:. .:||:.: .|.|
  Fly   421 P----------------------------PTYFRLNKFTRGFQNLIDAYGMADYKELNPAPYTII 457

Human   452 ------APAYGPVLH-------------LHR-LHLQRVLQSRHQHLPLGLECGRH---------- 486
                  |..:|.:.|             .|| :...::..:....:...|..||:
  Fly   458 TFPFLFAVMFGDLGHGILLILFSSLMIWKHREIEKYQINATSENEILNILYAGRYIILLMGVFSV 522

Human   487 --GQPVWLEVRPGPQ---PGWGPRSTRSPDRPPLRCRSDAFLAQHTMLTLDPNVTGVFLG-PYPF 545
              |....:.:..|..   ..|..|...:....|         |.|  :|||.:....:.| |||.
  Fly   523 YMGLVYNIVMAKGFNLFGSSWSCRYNETTVYDP---------AFH--VTLDSSHPHFYSGHPYPL 576

Human   546 GIDPIWSLAA-NHLSFLNSFKMKMSVILGVVHMAFGVVLGVFNHVHFGQRHRLLLETLPELTFLL 609
            |:||:|::.. :.::..||.||||:::||:..|.||:.|...|.|...::..|:|..:|::.|:|
  Fly   577 GMDPVWAVCGQDSITTTNSLKMKMAIVLGISQMMFGLGLAAANCVLMNRKADLILVVIPQMIFML 641

Human   610 GLFGYLVFLVIYKWLCVWAAR-----AASAPSILIHFINMFLF-SHSPSNRLL---YPRQEVVQA 665
            .||||||||:.|||:.....:     ||.|||:||.||||.|. ...|....|   ||.:.:::.
  Fly   642 CLFGYLVFLIFYKWMSYGGHKPAPYNAACAPSVLITFINMMLMKKEDPVENCLDYMYPNERMIEF 706

Human   666 TLVVLALAMVPILLLGTPLHLLHRHRRRLRRRPADRQEENKAGLLDLPDAS--VNGWSSDEEKAG 728
            .||.:|...:||||.|.|::|:.|.|:..:.|..|.:...:..:.::....  .:..:|:..:..
  Fly   707 ALVGIAFCTIPILLAGKPIYLMRRRRKMQQERERDFKRMRRQTIAEMRSTMRYTDDDNSETSRQK 771

Human   729 GLDDEEEAELVPSEVLMHQAIHTIEFCLGCVSNTASYLRLWALSLAHAQLSEVLWAMVMRIGLGL 793
            .:|:|||.|:  ||:.:|..|||||..||.||:||||||||||||||.|||:|||.||:..|...
  Fly   772 SVDNEEEHEM--SEIWIHSGIHTIETVLGSVSHTASYLRLWALSLAHDQLSDVLWHMVLTKGFAN 834

Human   794 GREVGVAAVVLVPIFAAFAVMTVAILLVMEGLSAFLHALRLHWVEFQNKFYSGTGYKLSPFTFAA 858
            ...:.....||:..|.|:|::|||||::|||||||||.|||||||||:||:.|.|.....|.|..
  Fly   835 TLPLYYGVPVLMATFFAWAILTVAILVMMEGLSAFLHTLRLHWVEFQSKFFGGAGESFKAFNFPT 899

Human   859 TD 860
            ::
  Fly   900 SN 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TCIRG1	XP_024304088.1	V_ATPase_I	27..>238	CDD:332370	48/235 (20%)
		SelP_N	<357..400	CDD:309645	8/44 (18%)
		V_ATPase_I	<541..856	CDD:332370	142/327 (43%)
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:279793	247/946 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148436
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750