Protein Alignment ZNF267 and CG5245

DIOPT Version :10

• Sequence 1: NP_003405.4
• Gene: ZNF267 / 10308
• HGNCID: 13060
• Length: 743
• Species: Homo sapiens
• Sequence 2: NP_650197.1
• Gene: CG5245 / 41530
• FlyBaseID: FBgn0038047
• Length: 501
• Species: Drosophila melanogaster
• Alignment Length: 455
• Identity: 176/455 - (38%)
• Similarity: 247/455 - (54%)
• Gaps: 34/455 - (7%)

Human   262 KQEQSYKCNKCVEVCTQSLKHIQHQTIHIRENSYSYNKYDKDLSQSSNLRKQIIHNEEKPYKCEK 326
            ||..::||.:|.:..|:            :||            ..|:||   :|.||:|::|..
  Fly    77 KQTDTFKCTQCQKTFTR------------KEN------------LESHLR---LHAEERPFECSH 114

Human   327 CGDSLNHSLHLTQHQIIPTEEKPCKWKECGKVFNLNCSLYLTKQQQID-TGENLYKCKACSKSFT 390
            |..|.....|..:| ::..|::|.|...|.|.|..|.||   ||...: |||..:||..||.||.
  Fly   115 CSKSFGRRTHYKRH-LLKHEKRPHKCSHCSKTFTQNSSL---KQHLHEHTGERPFKCTQCSTSFA 175

Human   391 RSSNLIVHQRIHTGEKPYKCKECGKAFRCSSYLTKHKRIHTGEKPYKCKECGKAFNRSSCLTQHQ 455
            |.|:|.||.|.|:.|:|::|..|.|||:.:|:|.:|.|.|...:|:||..|.|:|...|.|.:|.
  Fly   176 RKSHLQVHLRTHSEERPFECTHCEKAFKNNSHLQEHLRTHQEARPFKCSHCSKSFKLRSILQKHL 240

Human   456 TTHTGEKLYKCKVCSKSYARSSNLIMHQRVHTGEKPYKCKECGKVFSRSSCLTQHRKIHTGENLY 520
            .|| .|:.:||..|.|::.::.:|.:|.|||.||.|:||..|.:.|:|:|.|..|...|.|:...
  Fly   241 LTH-AERSFKCTQCPKTFLQNDSLQIHLRVHAGEDPFKCPHCSETFARNSRLQLHLLEHAGKEPL 304

Human   521 KCKVCAKPFTCFSNLIVHERIHTGEKPYKCKECGKAFPYSSHLIRHHRIHTGEKPYKCKACSKSF 585
            ||..|:..|...|...||.|:||.|:.|||.||.|:|...|||:.|.::||||:|:||..|.|.|
  Fly   305 KCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQVHTGERPFKCTHCFKDF 369

Human   586 SDSSGLTVHRRTHTGEKPYTCKECGKAFSYSSDVIQHRRIHTGQRPYKCEECGKAFNYRSYLTTH 650
            ...:.|.||...|.|||...|..|.|.|..||.::.|.:.|||:..::|..|.|::...|.|..|
  Fly   370 KCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFECPHCSKSYTTSSTLHMH 434

Human   651 QRSHTGERPYKCEECGKAFNSRSYLTTHRRRHTGERPYKCDECGKAFSYRSYLTTH-RRSHSGER 714
            .|:||||.|:||..|.|.|...:....|.|.||||:||||..|...::.:|.|..| ||:..|.:
  Fly   435 LRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYTQKSSLGRHLRRTLCGTK 499

Human   715  714
              Fly   500  499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZNF267	NP_003405.4	KRAB	4..64	CDD:214630
		C2H2 Zn finger	269..289	CDD:275368	3/19 (16%)
		C2H2 Zn finger	297..316	CDD:275368	3/18 (17%)
		C2H2 Zn finger	324..341	CDD:275368	4/16 (25%)
		C2H2 Zn finger	353..374	CDD:275368	8/20 (40%)
		COG5048	364..730	CDD:227381	149/353 (42%)
		C2H2 Zn finger	382..402	CDD:275368	11/19 (58%)
		C2H2 Zn finger	410..430	CDD:275368	9/19 (47%)
		C2H2 Zn finger	438..458	CDD:275368	7/19 (37%)
		C2H2 Zn finger	466..486	CDD:275368	6/19 (32%)
		C2H2 Zn finger	494..514	CDD:275368	7/19 (37%)
		C2H2 Zn finger	522..542	CDD:275368	7/19 (37%)
		C2H2 Zn finger	550..570	CDD:275368	9/19 (47%)
		C2H2 Zn finger	578..598	CDD:275368	7/19 (37%)
		C2H2 Zn finger	606..626	CDD:275368	7/19 (37%)
		C2H2 Zn finger	634..654	CDD:275368	7/19 (37%)
		C2H2 Zn finger	662..682	CDD:275368	6/19 (32%)
		C2H2 Zn finger	690..710	CDD:275368	7/20 (35%)
		C2H2 Zn finger	718..738	CDD:275368
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	169/432 (39%)
		C2H2 Zn finger	84..104	CDD:275368	8/46 (17%)
		C2H2 Zn finger	112..132	CDD:275368	5/20 (25%)
		C2H2 Zn finger	139..159	CDD:275368	8/22 (36%)
		C2H2 Zn finger	167..187	CDD:275368	11/19 (58%)
		C2H2 Zn finger	195..215	CDD:275368	9/19 (47%)
		C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)