DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF267 and CG11247

DIOPT Version :9

Sequence 1:	NP_003405.4	Gene:	ZNF267 / 10308	HGNCID:	13060	Length:	743	Species:	Homo sapiens
Sequence 2:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	329	Identity:	110/329 - (33%)
Similarity:	165/329 - (50%)	Gaps:	26/329 - (7%)

- Green bases have known domain annotations that are detailed below.

Human   406 KPYKCKECGKAFRCSSYLTKHKRIHTGEKPYKCKECGKAFNRSSCLTQHQTT-HTGEKLYKCKVC 469
            |.:.|.:|.|.|...:.|.:|..||:.|:|:|||:|||::.::..|..|.|| |...|.:.|..|
  Fly    91 KHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQC 155

Human   470 SKSYARSSNLIMHQRVHTGEKPYKCKECGKVFSRSSCLTQHRKIH--TGENLYKCKVCAKPFTCF 532
            .||:|....|.:|.|:|:|||||.|..|.|.|:|...|.||...|  |....:.|..|:..|:..
  Fly   156 PKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTN 220

Human   533 SNLIVHERIHTGEKPYKCKECGKAF----PYSSHLIR-HHRIHTGEKPYKCKACSKSFSDSSGLT 592
            :||.||...|.....::|..|...|    ...:|:.: ||::    ..::|:.|.|.......|.
  Fly   221 ANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKL----TQFECEICHKMIEPDEDLA 281

Human   593 VHRRTHTGEKPYTCKECGKAFSYSSDVIQHRRIHTGQRPYKCEECGKAFNYRSYLTTHQRSHTGE 657
            .|.:.||..|.:.|:.|...|:..|....|.|:|||:|||:|..|.:.|.:.|.|..|.|.||||
  Fly   282 THMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGE 346

Human   658 RPYKCEECGK--AFNSRSYLTTHRRR-HTGERPYKCDECGKAFSYRSYLTTHRRSHSGERPYKCE 719
            :|::|:.|..  ||:..::|..|.:: |..::||.|:.|...|..:..|.:|           .|
  Fly   347 KPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSH-----------VE 400

Human   720 ECGK 723
            .|.|
  Fly   401 HCAK 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF267	NP_003405.4	KRAB	4..64	CDD:214630
		C2H2 Zn finger	269..289	CDD:275368
		C2H2 Zn finger	297..316	CDD:275368
		C2H2 Zn finger	324..341	CDD:275368
		C2H2 Zn finger	353..374	CDD:275368
		COG5048	364..730	CDD:227381	110/329 (33%)
		C2H2 Zn finger	382..402	CDD:275368
		C2H2 Zn finger	410..430	CDD:275368	6/19 (32%)
		C2H2 Zn finger	438..458	CDD:275368	9/20 (45%)
		C2H2 Zn finger	466..486	CDD:275368	8/19 (42%)
		C2H2 Zn finger	494..514	CDD:275368	8/19 (42%)
		C2H2 Zn finger	522..542	CDD:275368	7/19 (37%)
		C2H2 Zn finger	550..570	CDD:275368	6/24 (25%)
		C2H2 Zn finger	578..598	CDD:275368	5/19 (26%)
		C2H2 Zn finger	606..626	CDD:275368	6/19 (32%)
		C2H2 Zn finger	634..654	CDD:275368	7/19 (37%)
		C2H2 Zn finger	662..682	CDD:275368	6/22 (27%)
		C2H2 Zn finger	690..710	CDD:275368	5/19 (26%)
		C2H2 Zn finger	718..738	CDD:275368	3/6 (50%)
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	58/155 (37%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	12/24 (50%)
		C2H2 Zn finger	123..144	CDD:275368	9/20 (45%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	8/19 (42%)
		COG5048	<192..369	CDD:227381	56/180 (31%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	4/21 (19%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	6/22 (27%)
		C2H2 Zn finger	382..399	CDD:275368	5/27 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000