Protein Alignment KATNB1 and Katnb1

DIOPT Version :10

• Sequence 1: NP_005877.2
• Gene: KATNB1 / 10300
• HGNCID: 6217
• Length: 655
• Species: Homo sapiens
• Sequence 2: NP_083081.2
• Gene: Katnb1 / 74187
• MGIID: 1921437
• Length: 658
• Species: Mus musculus
• Alignment Length: 658
• Identity: 626/658 - (95%)
• Similarity: 634/658 - (96%)
• Gaps: 3/658 - (0%)

Human     1 MATPVVTKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSP 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MATPVVTKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSP 65

Human    66 VESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIK 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 VESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIK 130

Human   131 LWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVV 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 LWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVV 195

Human   196 EFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWE 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 EFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWE 260

Human   261 PERCFDVVLVNWGKVADLAICNDQLIGVAFSQSNVSSYVVDLTRVTRTGTVARDPVQDHRPLAQP 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||.:||||.::||.|.
Mouse   261 PERCFDVVLVNWGKVADLAICNDQLIGVAFSQSNVSSYVVDLTRVTRTGTVTQDPVQANQPLTQQ 325

Human   326 LPNPSAPLRRIYERPSTTCSKPQRVKQNSESERRSPSSEDDRDERESRAEIQNAEDYNEIFQPKN 390
            .|||...|||||||||||||||||||.||||||||||||||||||||||||||||||||||||||
Mouse   326 TPNPGVSLRRIYERPSTTCSKPQRVKHNSESERRSPSSEDDRDERESRAEIQNAEDYNEIFQPKN 390

Human   391 SISRTPPRRSEPFPAPPEDDAATAKEAAKPSPAMDV---QFPVPNLEVLPRPPVVASTPAPKAEP 452
            |||||||||||||||||||||||.||.:||||||||   |.|||||||..||.|:.||||||.||
Mouse   391 SISRTPPRRSEPFPAPPEDDAATVKEVSKPSPAMDVQLPQLPVPNLEVPARPSVMTSTPAPKGEP 455

Human   453 AIIPATRNEPIGLKASDFLPAVKIPQQAELVDEDAMSQIRKGHDTMCVVLTSRHKNLDTVRAVWT 517
            .||||||||||||||||||||||:||||||||||||||||||||||.||||||||||||||||||
Mouse   456 DIIPATRNEPIGLKASDFLPAVKVPQQAELVDEDAMSQIRKGHDTMFVVLTSRHKNLDTVRAVWT 520

Human   518 MGDIKTSVDSAVAINDLSVVVDLLNIVNQKASLWKLDLCTTVLPQIEKLLQSKYESYVQTGCTSL 582
            .||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   521 TGDIKTSVDSAVAINDLSVVVDLLNIVNQKASLWKLDLCTTVLPQIEKLLQSKYESYVQTGCTSL 585

Human   583 KLILQRFLPLITDMLAAPPSVGVDISREERLHKCRLCYKQLKSISGLVKSKSGLSGRHGSTFREL 647
            |||||||||||||:|||||||||||||||||||||||:||||||||||||||||||||||.||||
Mouse   586 KLILQRFLPLITDILAAPPSVGVDISREERLHKCRLCFKQLKSISGLVKSKSGLSGRHGSAFREL 650

Human   648 HLLMASLD 655
            ||||||||
Mouse   651 HLLMASLD 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KATNB1	NP_005877.2	Interaction with centrosomes	1..300		298/298 (100%)
		Interaction with dynein. /evidence=ECO:0000250	1..284		282/282 (100%)
		WD40	7..257	CDD:238121	249/249 (100%)
		WD40 repeat	67..103	CDD:293791	35/35 (100%)
		WD40 repeat	108..144	CDD:293791	35/35 (100%)
		WD40 repeat	151..186	CDD:293791	34/34 (100%)
		WD40 repeat	192..228	CDD:293791	35/35 (100%)
		WD40 repeat	234..261	CDD:293791	26/26 (100%)
		Interaction with PAFAH1B1. /evidence=ECO:0000250	285..434		132/151 (87%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	311..422		95/110 (86%)
		PRK12323	<386..>494	CDD:481241	95/110 (86%)
		Interaction with KATNA1 and NDEL1. /evidence=ECO:0000250	433..655		208/221 (94%)
		Katanin_con80	493..651	CDD:464044	152/157 (97%)
Katnb1	NP_083081.2	Interaction with centrosomes. /evidence=ECO:0000250	1..300		298/298 (100%)
		Interaction with dynein	1..284		282/282 (100%)
		WD40	7..257	CDD:238121	249/249 (100%)
		WD40 repeat	67..103	CDD:293791	35/35 (100%)
		WD40 repeat	108..144	CDD:293791	35/35 (100%)
		WD40 repeat	151..186	CDD:293791	34/34 (100%)
		WD40 repeat	192..228	CDD:293791	35/35 (100%)
		WD40 repeat	234..261	CDD:293791	26/26 (100%)
		Interaction with PAFAH1B1. /evidence=ECO:0000269|PubMed:16203747	285..437		132/151 (87%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	311..419		93/107 (87%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	434..458		16/23 (70%)
		Interaction with KATNA1 and NDEL1. /evidence=ECO:0000269|PubMed:16203747	436..658		208/221 (94%)
		Katanin_con80	496..654	CDD:464044	152/157 (97%)