Protein Alignment KATNB1 and katnb1

DIOPT Version :10

• Sequence 1: NP_005877.2
• Gene: KATNB1 / 10300
• HGNCID: 6217
• Length: 655
• Species: Homo sapiens
• Sequence 2: NP_998874.1
• Gene: katnb1 / 407924
• XenbaseID: XB-GENE-998271
• Length: 655
• Species: Xenopus tropicalis
• Alignment Length: 669
• Identity: 495/669 - (73%)
• Similarity: 562/669 - (84%)
• Gaps: 28/669 - (4%)

Human     1 MATPVVTKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSP 65
            ||||..|||.|||||||||.|:|||:||||:||||:|||||||||||||:|||||||||||||:|
 Frog     1 MATPSPTKTTWKLQEIVAHGSSVSSVVLGKSSGRLVATGGDDCRVNLWSVNKPNCIMSLTGHTTP 65

Human    66 VESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIK 130
            |||||.|..||||||||||||:||||||||||||||||||||:|||||||||:||||||.|||||
 Frog    66 VESVRFNNAEELIVAGSQSGSLRVWDLEAAKILRTLMGHKANVCSLDFHPYGDFVASGSLDTNIK 130

Human   131 LWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVV 195
            |||:|||||||||:||:||||||||||||||||||:|||:||||||||||||:|...|.||||::
 Frog   131 LWDVRRKGCVFRYKGHTQAVRCLRFSPDGKWLASASDDHSVKLWDLTAGKMMAELSEHKGPVNII 195

Human   196 EFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWE 260
            |||||||||||||:|||:|||||||||::.|.|||..|||::||:.||.|::.|.:|:|||||||
 Frog   196 EFHPNEYLLASGSADRTVRFWDLEKFQLIGCTEGETIPVRAILFSSDGGCIFCGGRDALRVYGWE 260

Human   261 PERCFDVVLVNWGKVADLAICNDQLIGVAFSQSNVSSYVVDLTRVTRTGTVARDPVQDHRPLAQP 325
            |::|||.|.|.||||.||||||.|||||:.:||.:||:|||||||..||...:.||....|::||
 Frog   261 PDQCFDTVPVGWGKVCDLAICNKQLIGVSSAQSTISSFVVDLTRVKMTGCAPQGPVPAEMPISQP 325

Human   326 LPNPSAPLRRIYERPSTTCSKPQRVKQNSESERRSPSSEDDRDERESRAEIQNAEDYNEIFQPKN 390
            .| ....|||||||||||||||:||         ||:|:|  :|:||||||||.|||.|||||||
 Frog   326 AP-AGTSLRRIYERPSTTCSKPKRV---------SPTSDD--EEKESRAEIQNPEDYKEIFQPKN 378

Human   391 SISRTPPRRSEPFPAPPEDDAATAKEAAKPSPAMDVQFPVP----NLEVLPRPPVVAST------ 445
            :|||||||.|||||||||||.:..||...|.|  ||..|..    |.|.|.||||.|||
 Frog   379 AISRTPPRNSEPFPAPPEDDTSILKEPVAPIP--DVVTPATSNKNNTEQLQRPPVAASTPIVCQE 441

Human   446 ----PAPKAEPAIIPATRNEPIGLKASDFLPAVKIPQQAELVDEDAMSQIRKGHDTMCVVLTSRH 506
                |||:::|.:|.|.|||||||||:|||||||.....|:||::|:|||||||||||:|||||.
 Frog   442 PSPVPAPQSKPPVISAARNEPIGLKAADFLPAVKTSSPTEVVDDEAVSQIRKGHDTMCMVLTSRM 506

Human   507 KNLDTVRAVWTMGDIKTSVDSAVAINDLSVVVDLLNIVNQKASLWKLDLCTTVLPQIEKLLQSKY 571
            :|||||||||:.||||||:||||||||||||||||||:||||||||||||.||||||||:|||||
 Frog   507 RNLDTVRAVWSSGDIKTSIDSAVAINDLSVVVDLLNIINQKASLWKLDLCLTVLPQIEKMLQSKY 571

Human   572 ESYVQTGCTSLKLILQRFLPLITDMLAAPPSVGVDISREERLHKCRLCYKQLKSISGLVKSKSGL 636
            ||||||||.|||||||||||||||:|||||||||||||||||.||:||||||:.:|.|||||:..
 Frog   572 ESYVQTGCISLKLILQRFLPLITDILAAPPSVGVDISREERLSKCKLCYKQLRILSPLVKSKASQ 636

Human   637 SGRHGSTFRELHLLMASLD 655
            |||:||.||||||||:.|:
 Frog   637 SGRYGSAFRELHLLMSGLE 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KATNB1	NP_005877.2	Interaction with centrosomes	1..300		237/298 (80%)
		Interaction with dynein. /evidence=ECO:0000250	1..284		228/282 (81%)
		WD40	7..257	CDD:238121	203/249 (82%)
		WD40 repeat	67..103	CDD:293791	31/35 (89%)
		WD40 repeat	108..144	CDD:293791	31/35 (89%)
		WD40 repeat	151..186	CDD:293791	31/34 (91%)
		WD40 repeat	192..228	CDD:293791	28/35 (80%)
		WD40 repeat	234..261	CDD:293791	15/26 (58%)
		Interaction with PAFAH1B1. /evidence=ECO:0000250	285..434		89/152 (59%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	311..422		67/110 (61%)
		PRK12323	<386..>494	CDD:481241	70/121 (58%)
		Interaction with KATNA1 and NDEL1. /evidence=ECO:0000250	433..655		176/231 (76%)
		Katanin_con80	493..651	CDD:464044	135/157 (86%)
katnb1	NP_998874.1	WD40	<7..295	CDD:441893	231/287 (80%)
		WD 1	18..58		33/39 (85%)
		WD 2	61..100		33/38 (87%)
		WD40 repeat	67..103	CDD:293791	31/35 (89%)
		WD 3	103..142		34/38 (89%)
		WD40 repeat	108..144	CDD:293791	31/35 (89%)
		WD 4	145..184		35/38 (92%)
		WD40 repeat	151..186	CDD:293791	31/34 (91%)
		WD 5	187..226		30/38 (79%)
		WD40 repeat	192..228	CDD:293791	28/35 (80%)
		WD 6	229..269		23/39 (59%)
		Herpes_BLLF1	<307..>506	CDD:282904	124/212 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	316..453		83/150 (55%)
		Katanin_con80	493..651	CDD:464044	135/157 (86%)