Protein Alignment KATNB1 and katnb1

DIOPT Version :10

• Sequence 1: NP_005877.2
• Gene: KATNB1 / 10300
• HGNCID: 6217
• Length: 655
• Species: Homo sapiens
• Sequence 2: NP_998183.1
• Gene: katnb1 / 406291
• ZFINID: ZDB-GENE-040426-1954
• Length: 694
• Species: Danio rerio
• Alignment Length: 700
• Identity: 436/700 - (62%)
• Similarity: 541/700 - (77%)
• Gaps: 52/700 - (7%)

Human     1 MATPVVTKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSP 65
            ||....|.|:|||||||||:||||||||||:|||||||||:|||||:|:::|||||||||||||.
Zfish     1 MALTNTTITSWKLQEIVAHSSNVSSLVLGKSSGRLLATGGEDCRVNIWAVSKPNCIMSLTGHTSA 65

Human    66 VESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIK 130
            |..::.|:.||.:||||.|||:|:|||||||||||||||||:|.||||||.||::||||.|:|||
Zfish    66 VGCIQFNSSEERVVAGSLSGSLRLWDLEAAKILRTLMGHKASISSLDFHPMGEYLASGSVDSNIK 130

Human   131 LWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVV 195
            |||:|||||||||:||:||||||.|||||||||||:||.|||||||.||||::||..||..||||
Zfish   131 LWDVRRKGCVFRYKGHTQAVRCLAFSPDGKWLASASDDSTVKLWDLIAGKMITEFTSHTSAVNVV 195

Human   196 EFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWE 260
            :||||||||||||:|||::.||||||.::...|||.|.||||||||||.|||||.:::|||||||
Zfish   196 QFHPNEYLLASGSADRTVKLWDLEKFNMIGSSEGETGVVRSVLFNPDGSCLYSGSENTLRVYGWE 260

Human   261 PERCFDVVLVNWGKVADLAICNDQLIGVAFSQSNVSSYVVDLTRVTRTGTVARDPVQDHRPLAQP 325
            |:||||||.|.||||:||||.|:|:|.|::|.:|||.|||||.||.::|:|.:..:||     :|
Zfish   261 PDRCFDVVHVGWGKVSDLAISNNQMIAVSYSHTNVSWYVVDLNRVKKSGSVIQGLIQD-----KP 320

Human   326 LPNPSA----PLRRIYERPSTTCSKPQRVKQNSES-------ERRSPSSEDDRDERESRAEIQNA 379
            :|.||:    .|||.||||:|:|: .|.:||:||:       |||||||||:::::||.|||.|.
Zfish   321 IPAPSSALGTTLRRNYERPTTSCT-GQEMKQSSEADRRSPEGERRSPSSEDEKEDKESSAEITNP 384

Human   380 EDYNEIFQPKNSISRTPPRRSEPFPAPPEDDAATAKEAAKPSPAMDVQFPVPNLEVLPRPPVVAS 444
            |||.|||||::.||||||:.:||||||.| .:.:.....||.|.:.:..||.:.....:.|:.:|
Zfish   385 EDYKEIFQPRSVISRTPPKTTEPFPAPLE-HSFSESVLEKPGPVVKIVTPVIDRAGQLKGPITSS 448

Human   445 TPAPKAEPAIIPA----------------------------------TRNEPIGLKASDFLPAVK 475
            ||..:.||.:|.|                                  ||||||||.|.|||...:
Zfish   449 TPVQRVEPTVIAAAPRPVAVVTTSASSPSRPVVNTTKPKPSTGIILSTRNEPIGLNAGDFLSHAR 513

Human   476 IPQQAELVDEDAMSQIRKGHDTMCVVLTSRHKNLDTVRAVWTMGDIKTSVDSAVAINDLSVVVDL 540
            ..:.:.:.||:|::|||||||||||:|:||.||||:||:||..||:|||:||||::||||:|||:
Zfish   514 NAKASAMGDEEALAQIRKGHDTMCVMLSSRSKNLDSVRSVWASGDVKTSLDSAVSMNDLSIVVDV 578

Human   541 LNIVNQKASLWKLDLCTTVLPQIEKLLQSKYESYVQTGCTSLKLILQRFLPLITDMLAAPPSVGV 605
            |||:|.|.|||||||||::|||||:||||:|||||||||.||||||:||.|||:|.|.|||||||
Zfish   579 LNIINLKPSLWKLDLCTSILPQIEELLQSRYESYVQTGCMSLKLILKRFWPLISDTLNAPPSVGV 643

Human   606 DISREERLHKCRLCYKQLKSISGLVKSKSGLSGRHGSTFRELHLLMASLD 655
            ||:||||..||:.||||||::|.:||:::...||||||||||.||||.||
Zfish   644 DITREERHQKCKACYKQLKNLSNVVKNRAEQVGRHGSTFRELQLLMAPLD 693

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KATNB1	NP_005877.2	Interaction with centrosomes	1..300		221/298 (74%)
		Interaction with dynein. /evidence=ECO:0000250	1..284		213/282 (76%)
		WD40	7..257	CDD:238121	189/249 (76%)
		WD40 repeat	67..103	CDD:293791	23/35 (66%)
		WD40 repeat	108..144	CDD:293791	28/35 (80%)
		WD40 repeat	151..186	CDD:293791	28/34 (82%)
		WD40 repeat	192..228	CDD:293791	25/35 (71%)
		WD40 repeat	234..261	CDD:293791	21/26 (81%)
		Interaction with PAFAH1B1. /evidence=ECO:0000250	285..434		76/159 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	311..422		59/121 (49%)
		PRK12323	<386..>494	CDD:481241	47/141 (33%)
		Interaction with KATNA1 and NDEL1. /evidence=ECO:0000250	433..655		144/255 (56%)
		Katanin_con80	493..651	CDD:464044	115/157 (73%)
katnb1	NP_998183.1	WD40	<9..289	CDD:441893	212/279 (76%)
		WD 1	18..58		32/39 (82%)
		WD 2	61..100		25/38 (66%)
		WD40 repeat	67..103	CDD:293791	23/35 (66%)
		WD 3	103..142		30/38 (79%)
		WD40 repeat	108..144	CDD:293791	28/35 (80%)
		WD 4	145..186		33/40 (83%)
		WD40 repeat	151..186	CDD:293791	28/34 (82%)
		WD 5	188..226		27/37 (73%)
		WD40 repeat	192..228	CDD:293791	25/35 (71%)
		WD 6	229..269		31/39 (79%)
		WD40 repeat	234..268	CDD:293791	27/33 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	319..410		50/91 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	470..492		0/21 (0%)
		Katanin_con80	531..689	CDD:464044	115/157 (73%)