Protein Alignment KATNB1 and kat80

DIOPT Version :10

• Sequence 1: NP_005877.2
• Gene: KATNB1 / 10300
• HGNCID: 6217
• Length: 655
• Species: Homo sapiens
• Sequence 2: NP_523363.2
• Gene: kat80 / 32581
• FlyBaseID: FBgn0040207
• Length: 819
• Species: Drosophila melanogaster
• Alignment Length: 842
• Identity: 227/842 - (26%)
• Similarity: 352/842 - (41%)
• Gaps: 224/842 - (26%)

Human     1 MATPVVTKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSP 65
            ||.|  .|...|:.:|.||.|.|:||.||: :||:|.|||:|..||||:|.:..|.||||||...
  Fly     1 MALP--RKLISKIYDIKAHDSRVTSLDLGE-TGRVLVTGGEDRNVNLWAIGQNECFMSLTGHNRS 62

Human    66 VESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIK 130
            ::.||....:..:.:....|.||.|||.:.||..||.||..::.:|||:|.||:|.|||.||.::
  Fly    63 IDCVRFAYKDNFVYSADDIGIIRRWDLNSQKIYSTLNGHMKSVRTLDFNPSGEYVVSGSNDTTVR 127

Human   131 LWDIRRK-GCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEF---PGHTGP 191
            |||::.: .|:...|||...|..::|||||.|:|||..:.::.:||:...|.:.||   |..|.
  Fly   128 LWDVQNENNCIKVCRGHMSHVNSVKFSPDGLWIASAGLEGSILIWDIRKSKQIMEFIADPPVTA- 191

Human   192 VNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPG-PVRSVLFNPDGCCLYSGCQDSLR 255
            :..|:|||.|:|||:|..|.|:..:|||..|:||......| .:|.:.|:.:|.||:.|....:.
  Fly   192 ITCVQFHPFEFLLAAGRVDGTVSIYDLEHQQLVSQTTHFYGQAIRCITFSDNGECLFVGSSSGIS 256

Human   256 VYGWEPERCFDVVLVNWGKVADLAICNDQLIGVAFSQSNVSSYVVDLTRVTRTGTVARDPVQDHR 320
            |.||||:|..|.:...|..:||:.:.|::||........||...:.|.||.
  Fly   257 VIGWEPDRELDHIKSTWSSLADMKVVNNKLICGCHEIDTVSINTISLDRVI-------------- 307

Human   321 PLAQP---LPN--PSAPLRRIYERP------STTCSKPQRVKQNSESERRSPSSEDDRDERESRA 374
            |..||   |||  .::..|:.:.|.      |...:||.:|::..|.::...||.:...|..:.|
  Fly   308 PFYQPPNSLPNFKHNSTNRKSFTRGNQKFRLSVGGAKPAQVQEEHEGDKSGLSSPNYSLEVVNEA 372

Human   375 EIQNAEDYNEIFQPKNSI-----------------------------------SRTPPRR----- 399
            .:::||.     .|.:|:                                   ||.|...
  Fly   373 VLESAET-----SPMSSLPPVHLASMAGSSADLAPHHVVYGGAIDSALRQGKYSRVPDNMASYGS 432

Human   400 ------------SEP-----------FPAPPEDDAATAK------EAAKP------SPAMDVQFP 429
                        :||           :|....::|...:      ::..|      :..|...||
  Fly   433 SYGAIDTRLMSLNEPSSLHKPDIYNLYPLDKNEEADVQQLEFNLNDSNPPILNNYDNYEMAEDFP 497

Human   430 V-PNLEVLPR--PPVVASTPAPKAEPAIIPAT--------------------------------- 458
            | .||..:..  .||.|::....:..:|...|
  Fly   498 VNQNLNYITNNYKPVPATSTINASSKSIKKTTTTTLHKRTTNNMAGAKQTSTGIFGGSKLSQVSS 562

Human   459 --------------------------RNEPIGLKASDF----------------LPAVK------ 475
                                      ...|:|...|.|                .|.::
  Fly   563 VSSMELHKLDDNMVLKKSSSSNVVNKNKRPMGSAQSQFSKENNQQKNINVEIITKPPMRSRTTLD 627

Human   476 -------------IPQQAE-----LVDEDAMSQIRKGHDTMCVVLTSRHKNLDTVRAVWTMGDIK 522
                         |.||..     ::|:.....:.:.|:.:...|::|..:||.:|......|:.
  Fly   628 MRTSHQAKTQEKQIHQQQPMNNRIIMDDHDFDMLSRSHEAVLQELSNRQSSLDLLRHATRSHDVL 692

Human   523 TSVDSAVAINDLSVVVDLLNIVNQKASLWKLDLCTTVLPQIEKLLQSKYESYVQTGCTSLKLILQ 587
            .::..|.:... |:.:|||..:.:|.|.|.||.|..|||:|.:||||:::.:....|.:|::||.
  Fly   693 GALRQARSCGK-SIFIDLLGAILEKPSSWNLDFCMFVLPEIYELLQSQHKFHFTRACDTLRIILS 756

Human   588 RFLPLITDMLA--APPSVGVDISREERLHKCRLCYKQLKSISGLVKSKSGLSGRHGSTFREL 647
            .|||.|.:.|.  |...:|||::||:|..||..|.:.|..|..|.:|.     ..|||..:|
  Fly   757 NFLPTIQENLDSWAANGLGVDVTREDRQRKCAECQRWLLQIKNLPEST-----HFGSTLSQL 813

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KATNB1	NP_005877.2	Interaction with centrosomes	1..300		122/303 (40%)
		Interaction with dynein. /evidence=ECO:0000250	1..284		118/287 (41%)
		WD40	7..257	CDD:238121	104/254 (41%)
		WD40 repeat	67..103	CDD:293791	12/35 (34%)
		WD40 repeat	108..144	CDD:293791	16/36 (44%)
		WD40 repeat	151..186	CDD:293791	14/37 (38%)
		WD40 repeat	192..228	CDD:293791	17/35 (49%)
		WD40 repeat	234..261	CDD:293791	9/26 (35%)
		Interaction with PAFAH1B1. /evidence=ECO:0000250	285..434		41/235 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	311..422		29/196 (15%)
		PRK12323	<386..>494	CDD:481241	30/284 (11%)
		Interaction with KATNA1 and NDEL1. /evidence=ECO:0000250	433..655		68/318 (21%)
		Katanin_con80	493..651	CDD:464044	53/157 (34%)
kat80	NP_523363.2	WD40	<11..263	CDD:441893	106/253 (42%)
		WD40 repeat	22..58	CDD:293791	20/36 (56%)
		WD40 repeat	63..99	CDD:293791	11/35 (31%)
		WD40 repeat	106..142	CDD:293791	16/35 (46%)
		WD40 repeat	148..184	CDD:293791	14/35 (40%)
		WD40 repeat	192..228	CDD:293791	17/35 (49%)
		WD40 repeat	285..310	CDD:293791	8/38 (21%)
		Katanin_con80	663..817	CDD:464044	53/157 (34%)