Protein Alignment KATNB1 and Katnb1

DIOPT Version :10

• Sequence 1: NP_005877.2
• Gene: KATNB1 / 10300
• HGNCID: 6217
• Length: 655
• Species: Homo sapiens
• Sequence 2: XP_017456687.1
• Gene: Katnb1 / 291852
• RGDID: 1311256
• Length: 659
• Species: Rattus norvegicus
• Alignment Length: 659
• Identity: 623/659 - (94%)
• Similarity: 633/659 - (96%)
• Gaps: 4/659 - (0%)

Human     1 MATPVVTKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSP 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MATPVVTKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSP 65

Human    66 VESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIK 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 VESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIK 130

Human   131 LWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVV 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 LWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVV 195

Human   196 EFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWE 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 EFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWE 260

Human   261 PERCFDVVLVNWGKVADLAICNDQLIGVAFSQSNVSSYVVDLTRVTRTGTVARDPVQDHRPLAQP 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||.:||||..:|..|.
  Rat   261 PERCFDVVLVNWGKVADLAICNDQLIGVAFSQSNVSSYVVDLTRVTRTGTVTQDPVQASQPQTQQ 325

Human   326 LPNPSAPLRRIYERPSTTCSKPQRVKQNSESERRSPSSEDDRDERESRAEIQNAEDYNEIFQPKN 390
            .|||...|||||||||||||||||||.||||||||||||||:|||||||||||||||||||||||
  Rat   326 TPNPGVSLRRIYERPSTTCSKPQRVKHNSESERRSPSSEDDKDERESRAEIQNAEDYNEIFQPKN 390

Human   391 SISRTPPRRSEPFPAPPEDDAATAKEAAKPSPAMDVQFPVPNLEVLPRPPVVASTPAPKAEPAII 455
            ||||||||||||||||||||.||||||:|||||||||.|||:.||..||.|:.||||||.||.||
  Rat   391 SISRTPPRRSEPFPAPPEDDIATAKEASKPSPAMDVQLPVPSQEVPARPSVMTSTPAPKGEPVII 455

Human   456 PATRNEPIGLKASDFLPAVKIPQQAELVDEDAMSQIRKGHDTMCVVLTSRHKNLDTVRAVWTMGD 520
            ||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||.||
  Rat   456 PATRNEPIGLKASDFLPAVKVPQQAELVDEDAMSQIRKGHDTMCVVLTSRHKNLDTVRAVWTTGD 520

Human   521 IKTSVDSAVAINDLSVVVDLLNIVNQKA----SLWKLDLCTTVLPQIEKLLQSKYESYVQTGCTS 581
            ||||||||||||||||||||||||||||    |||||||||||||||||||||||||||||||||
  Rat   521 IKTSVDSAVAINDLSVVVDLLNIVNQKACLSSSLWKLDLCTTVLPQIEKLLQSKYESYVQTGCTS 585

Human   582 LKLILQRFLPLITDMLAAPPSVGVDISREERLHKCRLCYKQLKSISGLVKSKSGLSGRHGSTFRE 646
            ||||||||||||||:|||||||||||||||||||||||:||||||||||||:|||||||||.|||
  Rat   586 LKLILQRFLPLITDILAAPPSVGVDISREERLHKCRLCFKQLKSISGLVKSRSGLSGRHGSAFRE 650

Human   647 LHLLMASLD 655
            |||||||||
  Rat   651 LHLLMASLD 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KATNB1	NP_005877.2	Interaction with centrosomes	1..300		298/298 (100%)
		Interaction with dynein. /evidence=ECO:0000250	1..284		282/282 (100%)
		WD40	7..257	CDD:238121	249/249 (100%)
		WD40 repeat	67..103	CDD:293791	35/35 (100%)
		WD40 repeat	108..144	CDD:293791	35/35 (100%)
		WD40 repeat	151..186	CDD:293791	34/34 (100%)
		WD40 repeat	192..228	CDD:293791	35/35 (100%)
		WD40 repeat	234..261	CDD:293791	26/26 (100%)
		Interaction with PAFAH1B1. /evidence=ECO:0000250	285..434		130/148 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	311..422		94/110 (85%)
		PRK12323	<386..>494	CDD:481241	94/107 (88%)
		Interaction with KATNA1 and NDEL1. /evidence=ECO:0000250	433..655		207/225 (92%)
		Katanin_con80	493..651	CDD:464044	152/161 (94%)
Katnb1	XP_017456687.1	WD40	7..257	CDD:238121	249/249 (100%)
		WD40 repeat	67..103	CDD:293791	35/35 (100%)
		WD40 repeat	108..144	CDD:293791	35/35 (100%)
		WD40 repeat	151..186	CDD:293791	34/34 (100%)
		WD40 repeat	192..228	CDD:293791	35/35 (100%)
		WD40 repeat	234..261	CDD:293791	26/26 (100%)
		PRK12323	<386..>494	CDD:481241	94/107 (88%)
		Katanin_con80	493..655	CDD:464044	152/161 (94%)