DRSC/TRiP Functional Genomics Resources

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Protein Alignment KATNB1 and F47G4.4

DIOPT Version :10

Sequence 1:NP_005877.2 Gene:KATNB1 / 10300 HGNCID:6217 Length:655 Species:Homo sapiens
Sequence 2:NP_493453.1 Gene:F47G4.4 / 173271 WormBaseID:WBGene00009825 Length:722 Species:Caenorhabditis elegans


Alignment Length:762 Identity:170/762 - (22%)
Similarity:293/762 - (38%) Gaps:225/762 - (29%)


- Green bases have known domain annotations that are detailed below.


Human    21 SNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTG------HTS-----PVESVRLNTP 74
            |.|.|.||.:....::..|             |..::.|.|      .||     |:|.:||:|.
 Worm    12 STVHSAVLSRRHRSVICAG-------------PYEVLPLEGCSEPLPSTSTLSELPIECLRLSTD 63

Human    75 EELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSL---DFHPYGEFVASGSQDTNIKLWDIRR 136
            |..|.|.: :..::|.|:.....:|.|.||...|.||   .|:||..:  :||.|.:...||.|.
 Worm    64 ERTIGAAT-NAILKVADIITGHEVRNLTGHTLPITSLAASKFNPYCWY--TGSSDCDWTQWDTRM 125

Human   137 KGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEF--PGHTGPVNVVEFHP 199
            .............||.:..||..:::|...|: |::::|....:.:..|  .||     .:|.||
 Worm   126 NPSKIFGSKTPGVVRSIALSPGDRYVAVGTDE-TIQIFDARQREFIKTFNCSGH-----ALELHP 184

Human   200 NEYLLASGSSDRTIRFWDLEKFQVVSCIEGEP--GPVRSVLFNPDGCCLYSGCQDSLRVYGWEPE 262
            ::.||:|...||.:||:.||.|:::|  :.:|  ..:::..|  |...:.:...||:.:..||| 
 Worm   185 SDVLLSSVGHDRIVRFFCLETFEMIS--QSDPFLDDIQASAF--DTHVMIAATNDSINLLTWEP- 244

Human   263 RCFDVV----LVNWGKVADL--------AIC-----------------------NDQLIGVAFSQ 292
             |.|::    |.|..||.::        .||                       :.:|.|..:.:
 Worm   245 -CCDILTTVPLKNVEKVVNVNANGLDLDFICIGDNTERLEMRTYAIEELLSYSPSHELCGSIYEE 308

Human   293 -SNVSSYVVD----LTRVTRTGTV-ARDP---VQDHRPLAQPLPNPSAPLRRIYERPSTTCSKPQ 348
             .:|.:..:|    |..:|....: .|.|   .::....|.|:.:.|:     :..| |:..||.
 Worm   309 DEDVDNSPIDEVKALPELTELSNLPPRSPGLSCEETETSASPVNSSSS-----HSSP-TSPVKPA 367

Human   349 RVKQNSESER-----------------RS---PSSEDDRDERESRAEIQNAE----DYNEIFQPK 389
            .||..|.|::                 ||   .|::..|....:::.|.:::    .||....|.
 Worm   368 PVKHRSASQKLPGKSTKTLNPKPAGSTRSVTPVSTKPPRTFGTAKSVIVSSKPSLSGYNNRANPS 432

Human   390 NSIS------------------RTPPRRS-------EPFP--------APPEDDAATAKEAA--- 418
            .|:|                  |.|.:||       ||..        .|.|.|.|:...::   
 Worm   433 PSMSDLRTTKSMAGSTTSLLSERAPKKRSTSSRRNQEPITITYIGRPRTPSEGDVASTVSSSTSR 497

Human   419 --KPSPAMDVQFPVPNLEVLPRPPVVASTPAPKA-EPAIIPATRNE--------------PIGLK 466
              :|||::..:...|::.      .:.|:||.:| ..|..|..|.:              |:|:.
 Worm   498 NRRPSPSVAKKTSPPSIY------AITSSPAKRASSTASGPTARRQNSTSSVTSTTSAKTPVGVW 556

Human   467 ASDFLPAVKIPQQAELVDEDAMSQIRKGHDTMCVVLTSRH-KNLDTVRAVWTMGDIKTSVDSAVA 530
            .:    .::......:|.:.....||:     ..:||||. .|:|....|               
 Worm   557 GA----CIETVHDIGIVAKKENRNIRR-----LKMLTSRRTSNVDIPPEV--------------- 597

Human   531 INDLSVVVDLLNIVNQKASLWKLDLCTTVLPQIEKLLQSKYESYVQTGCTSLKLILQRFLPLITD 595
            .:|..:|:....|::::.. |.|:.|...||.|       .::......|:..:.|:. |..|.|
 Worm   598 CSDEQLVLTATRILSRRND-WSLNSCHAYLPVI-------IDNIASVDVTNRAIALEG-LAAIAD 653

Human   596 ML-------AAPPS--VGVDISREERLHKCRLCYKQLKSISGLVKSK 633
            .|       |:..|  :|||::.|||..|.:.|.:.|:|   |||.:
 Worm   654 TLGERLVKFASMNSHRIGVDVAAEERAEKAKACVQHLRS---LVKKR 697

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KATNB1NP_005877.2 Interaction with centrosomes 1..300 81/332 (24%)
Interaction with dynein. /evidence=ECO:0000250 1..284 78/315 (25%)
WD40 7..257 CDD:238121 67/253 (26%)
WD40 repeat 67..103 CDD:293791 11/35 (31%)
WD40 repeat 108..144 CDD:293791 12/38 (32%)
WD40 repeat 151..186 CDD:293791 8/36 (22%)
WD40 repeat 192..228 CDD:293791 14/35 (40%)
WD40 repeat 234..261 CDD:293791 5/26 (19%)
Interaction with PAFAH1B1. /evidence=ECO:0000250 285..434 43/219 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 311..422 34/176 (19%)
PRK12323 <386..>494 CDD:481241 29/160 (18%)
Interaction with KATNA1 and NDEL1. /evidence=ECO:0000250 433..655 49/226 (22%)
Katanin_con80 493..651 CDD:464044 37/151 (25%)
F47G4.4NP_493453.1 WD40 54..>236 CDD:475233 54/194 (28%)
WD40 repeat 56..91 CDD:293791 11/35 (31%)
WD40 repeat 96..132 CDD:293791 12/37 (32%)
WD40 repeat 140..174 CDD:293791 7/34 (21%)
WD40 repeat 177..207 CDD:293791 14/34 (41%)
WD40 repeat 215..258 CDD:293791 11/46 (24%)
PTZ00449 <304..>482 CDD:185628 33/183 (18%)
Katanin_con80 <610..698 CDD:464044 28/100 (28%)

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