Protein Alignment ADAR and stau

DIOPT Version :10

• Sequence 1: NP_001351974.1
• Gene: ADAR / 103
• HGNCID: 225
• Length: 1235
• Species: Homo sapiens
• Sequence 2: NP_476751.1
• Gene: stau / 37065
• FlyBaseID: FBgn0003520
• Length: 1026
• Species: Drosophila melanogaster
• Alignment Length: 945
• Identity: 177/945 - (18%)
• Similarity: 293/945 - (31%)
• Gaps: 310/945 - (32%)

Human   215 QHSGVVRPDGHSQGAPNSDPSLEP-----------------EDRNSTSVSEDLLEPFIAVSAQAW 262
            ||.|   |....|..|...|...|                 :.:..||.::     ..||:|...
  Fly    35 QHLG---PSLQQQQQPPPPPQQPPHRDLHARLNHHHLHAQQQQQQQTSSNQ-----AGAVAAAGA 91

Human   263 NQHSGVVRPDSHSQGSPNSD-----------------------PGLEPEDSN------------- 291
            ..|.|.:..:|.|..|.||:                       ||..|:..|
  Fly    92 AYHHGNINSNSGSNISSNSNQMQKIRQQHQHLSSSNGLLGNQPPGPPPQAFNPLAGNPAALAYNQ 156

Human   292 -------------STSALEDPLEFLDMAEIKEKICDYLFNVSDSSALNLAKNIGLTKARDINAVL 343
                         .:.|...|..::..|: ..|...|..|.:.:|..|.:.:....|     |:|
  Fly   157 LPPHPPHHMAAHLGSYAAPPPHYYMSQAK-PAKYNHYGSNANSNSGSNNSNSNYAPK-----AIL 215

Human   344 IDMERQGDVYRQGTTPPIWHLTDKKRERMQIKRNTNSVPETAPAAIPETKRNAEFLTCNIPTSNA 408
            .:..|...|    ..||:                   |.|..|...|....|      |..|::.
  Fly   216 QNTYRNQKV----VVPPV-------------------VQEVTPVPEPPVTTN------NATTNST 251

Human   409 SNNMVTTEKVENGQEPVIKLENRQ--EARPEPARLKPPVHYNGPSKAGYVDFENGQWATDDIPDD 471
            ||:.|.      ..|||.:.:..|  |.|.|||.....|      ..|.:|      ||..:.::
  Fly   252 SNSTVI------ASEPVTQEDTSQKPETRQEPASADDHV------STGNID------ATGALSNE 298

Human   472 LNSIRAAPGEFRAIMEMPSFYSHGLPRCSPYKKLTECQLKNPISGLLEYAQFASQTCEFNMIEQS 536
            ..|.....|:.                            |.|:..:.|.|::...|.::.:.|:.
  Fly   299 DTSSSGRGGKD----------------------------KTPMCLVNELARYNKITHQYRLTEER 335

Human   537 GPPHEPRFKFQVVINGREFPPAEAGSKKVAKQDAAMKAMTILLEEAKAKDSGKSEESSHYSTE-- 599
            ||.|...|...:::...|: .|:....|.|:..||.||:...:.:.......:|||.....|.
  Fly   336 GPAHCKTFTVTLMLGDEEY-SADGFKIKKAQHLAASKAIEETMYKHPPPKIRRSEEGGPMRTHIT 399

Human   600 ----------KESEKTAESQTPT--PSATSF----FSG------------KSPVTTLLECMHKLG 636
                      |..::|.....||  |...|.    |:|            :.|.........:||
  Fly   400 PTVELNALAMKLGQRTFYLLDPTQIPPTDSIVPPEFAGGHLLTAPGPGMPQPPPPPAYALRQRLG 464

Human   637 NSCEFRLLSKE--------GPAHEP-------KFQYCVAVGAQT-------FPSVSAPSKKV--- 676
            |.  |..:..:        ||...|       :|.....:||..       ||||..|..|:
  Fly   465 NG--FVPIPSQPMHPHFFHGPGQRPFPPKFPSRFALPPPLGAHVHHGPNGPFPSVPTPPSKITLF 527

Human   677 ---------------AKQMAAEEAMKALHGEATNSMASDNQPEGMISESLDNLESMMPNKVRKIG 726
                           ||..||..|::.|..:|             ||.|.:.||..|....:|
  Fly   528 VGKQKFVGIGRTLQQAKHDAAARALQVLKTQA-------------ISASEEALEDSMDEGDKK-- 577

Human   727 ELVRYLNTNPVGGLLEYARSHGFAAEFKLVDQSGPPHEPKFVYQAKVGGRWFPAVCAHSKKQGKQ 791
                    :|:..:.|..........||::.:.||.|...|:....||     ::....:..||:
  Fly   578 --------SPISQVHEIGIKRNMTVHFKVLREEGPAHMKNFITACIVG-----SIVTEGEGNGKK 629

Human   792 EAADAALRVLIGENEKAERMGFTEVTPV----------TGASLRRTMLL-------LSRSPEAQP 839
            .:...|...::.|.:|...:..|:.||:          :||:.|...::       .:..||.:.
  Fly   630 VSKKRAAEKMLVELQKLPPLTPTKQTPLKRIKVKTPGKSGAAAREGSVVSGTDGPTQTGKPERRK 694

Human   840 KTLPLTGSTFHDQIAMLSHRCFNTLTNSFQPSLLGRKILAAIIMKKDSEDMGVVVSLGTGNRCVK 904
            :..|.     .|::..:.. ..|.:|          |::.....:|:.|.:..:::       ..
  Fly   695 RLNPP-----KDKLIDMDD-ADNPIT----------KLIQLQQTRKEKEPIFELIA-------KN 736

Human   905 GDSLSLKGETVNDCHAEIISRRGFIRFLYSELMKYNSQTAKDSIFEPAKGGEKLQIKKTVSFHLY 969
            |:..:.:.|.|.:..|...:.||     .....|...:.|..::||..   |.:|:..|....
  Fly   737 GNETARRREFVMEVSASGSTARG-----TGNSKKLAKRNAAQALFELL---EAVQVTPTNETQ-- 791

Human   970 ISTAPCGDGALFDKSCSDRAMESTESRHYPVFENP 1004
             |:..|...|.. .:.:..|:|:|.....|:...|
  Fly   792 -SSEECSTSATM-SAVTAPAVEATAEGKVPMVATP 824

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADAR	NP_001351974.1	z-alpha	144..210	CDD:280459
		z-alpha	304..368	CDD:280459	13/63 (21%)
		DSRM_DRADA_rpt1	511..581	CDD:380742	18/69 (26%)
		DSRM_DRADA_rpt2	622..692	CDD:380743	23/109 (21%)
		DSRM_DRADA_rpt3	734..804	CDD:380744	13/69 (19%)
		ADEAMc	848..1231	CDD:214718	27/157 (17%)
stau	NP_476751.1	DSRM_STAU_rpt1	311..373	CDD:380686	16/62 (26%)
		DSRM_STAU_rpt2	473..553	CDD:380687	17/79 (22%)
		DSRM_STAU_rpt3	579..643	CDD:380688	13/68 (19%)
		DSRM_STAU_rpt4	711..780	CDD:380689	15/93 (16%)
		DSRM_STAU_rpt5	952..1019	CDD:380690