Protein Alignment PAK4 and STE20

DIOPT Version :10

• Sequence 1: NP_005875.1
• Gene: PAK4 / 10298
• HGNCID: 16059
• Length: 591
• Species: Homo sapiens
• Sequence 2: NP_011856.1
• Gene: STE20 / 856382
• SGDID: S000000999
• Length: 939
• Species: Saccharomyces cerevisiae
• Alignment Length: 660
• Identity: 210/660 - (31%)
• Similarity: 308/660 - (46%)
• Gaps: 180/660 - (27%)

Human     9 VEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQPGAPKTIVRG 73
            :.||.|.|.:|..|.|.|....::||||.:|:.|:..|..
Yeast   335 LRISTPYNAKHIHHVGVDSKTGEYTGLPEEWEKLLTSSGI------------------------- 374

Human    74 SKGAKDGALTLLLDEFE-NMSVTRSNSLRRDSPPPPARARQENGMPEEPATTARGGPGKAGSRGR 137
            ||..:...:..::|..: ...||.:|
Yeast   375 SKREQQQNMQAVMDIVKFYQDVTETN--------------------------------------- 400

Human   138 FAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQPAGLASGAKLAAG 202
                             |.:|..|:....:|.|          ..|.|.|| ||
Yeast   401 -----------------GEDKMFKTFNTTTGLP----------GSPQVSTP-PA----------- 426

Human   203 RPFNTYPRADTDHPSRGAQ-GEP---HDVAP----NGPSAGGLAIPQ-------SSSSSSRP--- 249
            ..||.:|.:.:|..:.|:: |.|   |.::|    :..||.|..||.       ||:|:|.|
Yeast   427 NSFNKFPPSTSDSHNYGSRTGTPMSNHVMSPTLNTDSSSANGKFIPSRPAPKPPSSASASAPIIK 491

Human   250 -----------PTRARGAP-SPGVLGPHAS----------EPQLAPP------------------ 274
                       |.:...|| :|....|:.|          |.|..||
Yeast   492 SPVMNSAANVSPLKQTHAPTTPNRTSPNRSSISRNATLKKEEQPLPPIPPTKSKTSPIISTAHTP 556

Human   275 ---ACTPAAPAVPGPPGPRSPQREPQRVSHE--------------QFRAALQLVVDPGDPRSYLD 322
               |.:|.|||......|.|...:.:.:|.|              |..|.|..:...|||.:...
Yeast   557 QQVAQSPKAPAQETVTTPTSKPAQARSLSKELNEKKREERERRKKQLYAKLNEICSDGDPSTKYA 621

Human   323 NFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLV 387
            |.:|||:|::|.|..|....:...||:|:|:|.||.::||:.||:::|:..:|.|:|...:||::
Yeast   622 NLVKIGQGASGGVYTAYEIGTNVSVAIKQMNLEKQPKKELIINEILVMKGSKHPNIVNFIDSYVL 686

Human   388 GDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDG 452
            ..:|||:||::|||:|||:|||..:.|.||.|||...|..|..||::||:|||||||:|||:.:|
Yeast   687 KGDLWVIMEYMEGGSLTDVVTHCILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSDNILLSMEG 751

Human   453 RVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFN 517
            .:||:|||||||:::...:|.::||||||||||::||..|||:|||||||||:|||::|||||.|
Yeast   752 DIKLTDFGFCAQINELNLKRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLN 816

Human   518 EPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAK-AGPPASI 581
            |.||:|:.:|..|..|:||....:|.|||.|||..|..:|..||:|.|||...::.: |...:|:
Yeast   817 ETPLRALYLIATNGTPKLKEPENLSSSLKKFLDWCLCVEPEDRASATELLHDEYITEIAEANSSL 881

Human   582 VPLMRQNRTR 591
            .||::..|.:
Yeast   882 APLVKLARLK 891

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAK4	NP_005875.1	CRIB_PAK_like	10..55	CDD:238526	15/44 (34%)
		Linker	25..320		69/370 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..301		49/266 (18%)
		GEF-interaction domain (GID)	298..323		8/38 (21%)
		STKc_PAK4	300..591	CDD:132988	142/305 (47%)
STE20	NP_011856.1	PBD	336..394	CDD:395634	18/82 (22%)
		STKc_PAK	619..872	CDD:270789	129/252 (51%)