Protein Alignment PAK4 and pak4

DIOPT Version :10

• Sequence 1: NP_005875.1
• Gene: PAK4 / 10298
• HGNCID: 16059
• Length: 591
• Species: Homo sapiens
• Sequence 2: NP_001002222.3
• Gene: pak4 / 431769
• ZFINID: ZDB-GENE-040704-69
• Length: 663
• Species: Danio rerio
• Alignment Length: 689
• Identity: 427/689 - (61%)
• Similarity: 477/689 - (69%)
• Gaps: 124/689 - (17%)

Human     1 MFGKRKK-RVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQP 64
            ||.|:|| |::|||||||||||||.||:.||||.|||||||||||::|:||||.:|...||:::|
Zfish     1 MFSKKKKQRIQISAPSNFEHRVHTDFDEQEQKFVGLPRQWQSLIEDTAKRPKPFIDATVITTVEP 65

Human    65 GAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPP----------------------- 106
              .||||||.|...||:||.||||||.|||.|||||||.|||
Zfish    66 --RKTIVRGRKIGDDGSLTWLLDEFETMSVIRSNSLRRGSPPLQPRSDSGSSGGHENGEHPQYRH 128

Human   107 --------------------------PPARARQENGMPEEPATTARG------------GPGKAG 133
                                      .|.|:.:|:|.|::   ..||            .||:..
Zfish   129 TDRYGDSKEREKPRQEHPGTDPRQSQRPGRSSREDGRPQQ---QPRGQEPSRHKEPDWITPGQHR 190

Human   134 SRGR--------FAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQ- 189
            .|.|        ::.|..       ||....:||||||..|.....:|.|:|||||||::.||.
Zfish   191 ERERDREREPRDYSDHVV-------RREGANDKRPKSSYTGRDSSPQSPREKRPLSGPNIRTPNL 248

Human   190 --PAGLASGAKLAAGRPFNTYPRADTD----------HPSRGAQGEPHDVAPNGPSAGGLAIPQS 242
              ..|:...|: ..|||||||||:::|          .|::..:...|    ||||||  .:...
Zfish   249 PVTEGVIKAAQ-QTGRPFNTYPRSESDSGRTPSGQDLKPAKSHESTHH----NGPSAG--PVRGG 306

Human   243 SSSSSRPPTRARGAPSPGVLGPHASEPQ--LAPPACTPAAP---AVPGPPGP----------RSP 292
            |||||       |.......|||.||||  .:.||..|..|   .:|.||.|          |||
Zfish   307 SSSSS-------GGGQTSSQGPHRSEPQHHASHPALGPEPPHGQPMPPPPKPSGPGAPSQQTRSP 364

Human   293 QREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQ 357
            |||||||||||||||||:||||||||:|||::||||||||||||||||:::||||||||||||||
Zfish   365 QREPQRVSHEQFRAALQMVVDPGDPRTYLDHYIKIGEGSTGIVCIATVKTTGKLVAVKKMDLRKQ 429

Human   358 QRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCL 422
            ||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||:.|||
Zfish   430 QRRELLFNEVVIMRDYHHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQISTVCL 494

Human   423 AVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI 487
            :||:||||||:||||||||||||||||||||||||||||||||||||.|||||||||||||||||
Zfish   495 SVLKALSVLHSQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVQRRKSLVGTPYWMAPELI 559

Human   488 SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRL 552
            |||||||||||||.||||||||||||||||||||||||||||||||:|||||||||.|||||||:
Zfish   560 SRLPYGPEVDIWSFGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPKLKNLHKVSPLLKGFLDRM 624

Human   553 LVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR 591
            |||||||||||.||||||||.|||||:.|||||||||.|
Zfish   625 LVRDPAQRATAQELLKHPFLTKAGPPSCIVPLMRQNRMR 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PAK4	NP_005875.1	CRIB_PAK_like	10..55	CDD:238526	35/44 (80%)
		Linker	25..320		157/391 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	95..301		93/302 (31%)
		GEF-interaction domain (GID)	298..323		22/24 (92%)
		STKc_PAK4	300..591	CDD:132988	268/290 (92%)
pak4	NP_001002222.3	None